(v. t.) To load or fill to excess; to load too heavily.
(n.) An excessive load; the excess beyond a proper load.
Example Sentences:
(1) By means of rapid planar Hill type antimony-bismuth thermophiles the initial heat liberated by papillary muscles was measured synchronously with developed tension for control (C), pressure-overload (GOP), and hypothyrotic (PTU) rat myocardium (chronic experiments) and after application of 10(-6) M isoproterenol or 200 10(-6) M UDCG-115.
(2) In iron-overloaded patients with primary haemochromatosis, there was inappropriately high uptake of iron by the biopsy specimens.
(3) The patient presented urgently for Caesarean section, with fluid overload and worsening thrombocytopaenia.
(4) Al hepatocytes overload appeared only in nuclei and not in nuclei and not in lysosomes, contrarily to chronic intoxications.
(5) Fluid overload, which could have been caused by the hyperosmolar properties of dextran, worsened progressively as fluids were drawn from the interstitial space and urine output was reduced.
(6) There were no significant differences between the mean levels of peak blood pressures (systolic, diastolic and mean), degree of fluid overload, and fractional sodium excretion in the 2 groups.
(7) Persisting diastolic dysfunction with a substantial rise in left ventricular filling pressure can be observed during dynamic exercise in postoperative patients with preoperative severe pressure overload hypertrophy.
(8) The 8 men and 3 women were clinically stable, were known to be compliant, and had no clinical evidence of aluminum overload; they were not receiving vitamin D supplements; and they had been on dialysis for an average of 65.6 months (range: 13-188 months).
(9) Wilson disease is due to a genetically determined impairment of copper excretion from liver into bile resulting in copper overload of the organism.
(10) There was no change in the sarcolemmal Mg2+ -ATPase of the left or right ventricle for the whole duration (3 to 9 months) of left ventricular pressure overload.
(11) These experimental results demonstrate that aluminium interferes with iron absorption and iron transfer, and suggest that these mechanisms may be responsible for maintaining and even increasing the anaemia observed in aluminium overload.
(12) When a high dose of the complex was administered, an overloading with hemosiderin of macrophages and hepatocytes was noticed.
(13) The subsequent accumulation of Na+ in the cell Na(+)-Ca2+ exchange, which can ultimately result in intracellular Ca2+ overload, contractile dysfunction and damage.
(14) If overloaded, these areas are subject to "cervical cratering," a common prelude to implant failure.
(15) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(16) Cardiac hypertrophy due to a chronic hemodynamic overload is accompanied by isoformic changes of two proteins of the thick filament of the sarcomere, myosin, and creatine phosphokinase.
(17) Age, gender and laboratory markers of iron overload did not differentiate patients with cardiac dysfunction (group 1) from those without cardiac dysfunction (group 2).
(18) Severe overloading can increase microdamage alarmingly, its repair by BMUs too, and can cause woven bone formation, anarchic resorption and a regional acceleratory phenomenon.
(19) Thus, it appears that the increased expression of the regulatory MLC2 gene in SHR atrial cells is a predetermined event, which, most likely, participates in functional adaptation of the myocardium in response to pressure overload and subsequent hypertrophy.
(20) To help resolve the issue of contractile function in volume overload hypertrophy, we examined ventricular function in a recently described model of severe chronic experimental mitral regurgitation.
Overwhelmed
Definition:
(imp. & p. p.) of Overwhelm
Example Sentences:
(1) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(2) She added: “We will continue to act upon the overwhelming majority view of our shareholders.” The vote was the second year running Ryanair had suffered a rebellion on pay.
(3) T cells admixed in the germinal centers were overwhelmingly of the T-helper type.
(4) Unfortunately for the governor, he could win both states and still face the overwhelming likelihood of failure if he doesn't take Ohio, where the poll found Obama out front 51-43.
(5) In Britain, the European election is overwhelmingly seen through the prism of domestic politics.
(6) Photograph: Christopher Thomond for the Guardian Asked if Watson should seek to refresh his mandate after Corbyn’s overwhelming victory among members, McCluskey added: “Well, if Tom wants to try to refresh his mandate it would be interesting to see what happens.” Watson said it was time “to be proud of our party”, because the Conservatives were beatable and the prime minister, Theresa May, could call an election any time.
(7) The government acknowledged it had been overwhelmed by the devastation from the deadliest quake in Nepal in over 80 years.
(8) He made me laugh and cry, and his courage in writing about what he was going through was sometimes quite overwhelming.
(9) Although alpha 1-antiprotease (alpha 1-AP) binds and inactivates NE and is the major antielastase of the lower respiratory tract, antielastase defenses may be overwhelmed in CF, leading to progressive lung damage.
(10) And HAP has shown that the key finding that debt slows growth was driven overwhelmingly by the exclusion of four years of data from New Zealand.
(11) Cathepsin D-like acid proteinase existed overwhelmingly in the mucosal layer and was hardly detected in the gastric juice.
(12) Hence, reaction of chemical carcinogen with nuclear DNA is possible only when the cell is overwhelmed leading to cell death, or following a temporary breach of the nuclear membrane control points, but the DNA damage in the latter is totally reparable.
(13) The facts are clear: the overwhelming majority of EU citizens in Britain are contributors, not freeloaders.” But that was not the official position of any of the parties involved, so it went mostly unsaid.
(14) Of 54 patients with poor-grade aneurysms, ventriculostomy was placed in 47 (87.0%) and yielded high ICP's in the overwhelming majority, with the mean ICP being 40.2 cm H2O.
(15) There is overwhelming evidence, today, that such factors are involved in the manifestation of acute as well as chronic, non-specific as well as well as specific inflammation.
(16) Mobile phone networks, overwhelmed by demand, were down for hours, with authorities advising people to use email or text messages instead.
(17) The immunity was enacted by an overwhelming bipartisan vote, with the support of leading Democrats including Barack Obama, who had promised - when seeking his party's nomination - to filibuster any bill that contained retroactive telecom immunity.
(18) There’s an overwhelming sadness among kids like that who have been kept there for a very long time.
(19) Panic attacks would overwhelm her periodically and she experienced regular “ scanxiety ” – the feelings of dread that grip patients before new tests.
(20) In the meantime, Malaysia Airlines’ overwhelming focus will be the same as it has been from the outset – to provide the families with a comprehensive support programme.