(1) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(2) She added: “We will continue to act upon the overwhelming majority view of our shareholders.” The vote was the second year running Ryanair had suffered a rebellion on pay.
(3) T cells admixed in the germinal centers were overwhelmingly of the T-helper type.
(4) Unfortunately for the governor, he could win both states and still face the overwhelming likelihood of failure if he doesn't take Ohio, where the poll found Obama out front 51-43.
(5) In Britain, the European election is overwhelmingly seen through the prism of domestic politics.
(6) Photograph: Christopher Thomond for the Guardian Asked if Watson should seek to refresh his mandate after Corbyn’s overwhelming victory among members, McCluskey added: “Well, if Tom wants to try to refresh his mandate it would be interesting to see what happens.” Watson said it was time “to be proud of our party”, because the Conservatives were beatable and the prime minister, Theresa May, could call an election any time.
(7) The government acknowledged it had been overwhelmed by the devastation from the deadliest quake in Nepal in over 80 years.
(8) He made me laugh and cry, and his courage in writing about what he was going through was sometimes quite overwhelming.
(9) Although alpha 1-antiprotease (alpha 1-AP) binds and inactivates NE and is the major antielastase of the lower respiratory tract, antielastase defenses may be overwhelmed in CF, leading to progressive lung damage.
(10) And HAP has shown that the key finding that debt slows growth was driven overwhelmingly by the exclusion of four years of data from New Zealand.
(11) Cathepsin D-like acid proteinase existed overwhelmingly in the mucosal layer and was hardly detected in the gastric juice.
(12) Hence, reaction of chemical carcinogen with nuclear DNA is possible only when the cell is overwhelmed leading to cell death, or following a temporary breach of the nuclear membrane control points, but the DNA damage in the latter is totally reparable.
(13) The facts are clear: the overwhelming majority of EU citizens in Britain are contributors, not freeloaders.” But that was not the official position of any of the parties involved, so it went mostly unsaid.
(14) Of 54 patients with poor-grade aneurysms, ventriculostomy was placed in 47 (87.0%) and yielded high ICP's in the overwhelming majority, with the mean ICP being 40.2 cm H2O.
(15) There is overwhelming evidence, today, that such factors are involved in the manifestation of acute as well as chronic, non-specific as well as well as specific inflammation.
(16) Mobile phone networks, overwhelmed by demand, were down for hours, with authorities advising people to use email or text messages instead.
(17) The immunity was enacted by an overwhelming bipartisan vote, with the support of leading Democrats including Barack Obama, who had promised - when seeking his party's nomination - to filibuster any bill that contained retroactive telecom immunity.
(18) There’s an overwhelming sadness among kids like that who have been kept there for a very long time.
(19) Panic attacks would overwhelm her periodically and she experienced regular “ scanxiety ” – the feelings of dread that grip patients before new tests.
(20) In the meantime, Malaysia Airlines’ overwhelming focus will be the same as it has been from the outset – to provide the families with a comprehensive support programme.
Strong
Definition:
(superl.) Having active physical power, or great physical power to act; having a power of exerting great bodily force; vigorous.
(superl.) Having passive physical power; having ability to bear or endure; firm; hale; sound; robust; as, a strong constitution; strong health.
(superl.) Solid; tough; not easily broken or injured; able to withstand violence; able to sustain attacks; not easily subdued or taken; as, a strong beam; a strong rock; a strong fortress or town.
(superl.) Having great military or naval force; powerful; as, a strong army or fleet; a nation strong at sea.
(superl.) Having great wealth, means, or resources; as, a strong house, or company of merchants.
(superl.) Reaching a certain degree or limit in respect to strength or numbers; as, an army ten thousand strong.
(superl.) Moving with rapidity or force; violent; forcible; impetuous; as, a strong current of water or wind; the wind was strong from the northeast; a strong tide.
(superl.) Adapted to make a deep or effectual impression on the mind or imagination; striking or superior of the kind; powerful; forcible; cogent; as, a strong argument; strong reasons; strong evidence; a strong example; strong language.
(superl.) Ardent; eager; zealous; earnestly engaged; as, a strong partisan; a strong Whig or Tory.
(superl.) Having virtues of great efficacy; or, having a particular quality in a great degree; as, a strong powder or tincture; a strong decoction; strong tea or coffee.
(superl.) Full of spirit; containing a large proportion of alcohol; intoxicating; as, strong liquors.
(superl.) Affecting any sense powerfully; as, strong light, colors, etc.; a strong flavor of onions; a strong scent.
(superl.) Solid; nourishing; as, strong meat.
(superl.) Well established; firm; not easily overthrown or altered; as, a strong custom; a strong belief.
(superl.) Violent; vehement; earnest; ardent.
(superl.) Having great force, vigor, power, or the like, as the mind, intellect, or any faculty; as, a man of a strong mind, memory, judgment, or imagination.
(superl.) Tending to higher prices; rising; as, a strong market.
(superl.) Pertaining to, or designating, a verb which forms its preterit (imperfect) by a variation in the root vowel, and the past participle (usually) by the addition of -en (with or without a change of the root vowel); as in the verbs strive, strove, striven; break, broke, broken; drink, drank, drunk. Opposed to weak, or regular. See Weak.
(superl.) Applied to forms in Anglo-Saxon, etc., which retain the old declensional endings. In the Teutonic languages the vowel stems have held the original endings most firmly, and are called strong; the stems in -n are called weak other constant stems conform, or are irregular.
Example Sentences:
(1) For some time now, public opinion polls have revealed Americans' strong preference to live in comparatively small cities, towns, and rural areas rather than in large cities.
(2) Perinatal mortality is strongly associated with obstetrical factors, respiratory distress syndrome, and prematurity.
(3) We conclude that the SHBG concentration strongly affects this estimation.
(4) When the data correlating DHT with protein synthesis using both labelling techniques were combined, the curves were parallel and a strong correlation was noted between DHT and protein synthesis over a wide range of values (P less than 0.001).
(5) A strong block to the elongation of nascent RNA transcripts by RNA polymerase II occurs in the 5' part of the mammalian c-fos proto-oncogene.
(6) Importantly, these characteristics were strong predictors of subsequent mortality.
(7) These clones, designated as TcHMC-2, showed strong cytotoxicity against both HMC-2 and K562 cells.
(8) Results demonstrate that the development of biliary strictures is strongly associated with the duration of cold ischemic storage of allografts in both Euro-Collins solution and University of Wisconsin solution.
(9) "There is … a risk that the political, trade, and gas frictions with Russia could lead to strong deterioration in economic relations between the two countries, with a significant drop in Ukraine's exports to and imports from Russia.
(10) Univariate and multivariate analyses indicated previous LBP or back pain in another location of the spine were strongly associated with LBP during the study year.
(11) Environment groups Environment groups that have strongly backed low-carbon power have barely wavered in their opposition to nuclear in the last decade, although their arguments now are now much about the cost than the danger it might pose.
(12) Although the productions of deoxycortisol and androstenedione from 17 alpha-hydroxyprogesterone were strongly inhibited by progesterone, androstenedione formation from progesterone was not inhibited by a high concentration of progesterone.
(13) Simple cells that are nearly equally dominated by each eye always exhibit strong phase-specific interaction.
(14) The activity is strongly inhibited by SH-blocking reagents (e.g.
(15) Nice (the National Institute for Health and Clinical Excellence) has also published new guidance on good patient experience that provides a strong framework on which to build good engagement practice.
(16) In 0.17 M Na+(aq), tRNA(Phe) exists in its native conformation and the number of strong binding sites (Ka greater than or equal to 10(4)) was estimated to be 3-4 by titration experiments, in agreement with X-ray structural data for crystalline tRNA(Phe) (Jack et al., 1977).
(17) The remaining 33 sera (13.3 per cent) were classified as low, moderate or strong positives.
(18) This study provides strong and unexpected evidence that one admission to hospital of more than a week's duration or repeated admissions before the age of five years (in particular between six months and four years) are associated with an increased risk of behaviour disturbance and poor reading in adolescence.
(19) The accumulated evidence would strongly favor an affirmative answer.
(20) Incubation of membrane with DL-Hcys alone (5 X 10(-5) M), the combination of both Ad (5 X 10(-5)) and DL-Hcys (5 X 10(-5)), or S-adenosyl-L-homocysteine (SAH) (1 X 10(-6)) strongly decreased the methyl ester formation.