(1) These results suggest that CsA has the potential to cause drug interactions involving inhibition of drug biotransformation, particularly of drugs that are metabolised by the same types of cytochrome P-450 which oxidise benzo[a]pyrene and theophylline.
(2) Charge transfer has been observed between oxidised tryptophan-26 units and the tyrosine-21 or -24 of the coat protein of fd phage.
(3) (1) The reaction of the resting form of oxidised cytochrome c oxidase from ox heart with dithionite has been studied in the presence and absence of cyanide.
(4) The data bearing that the increased activity of several oxidising enzymes in the testes of hereditary dwarf mice is increased with Prolactin, is consistent with the suggested effect of this hormone on testicular steroidogenesis.
(5) Some monohydroxytestosterones had also been oxidised at their 17-OH group, converting them into the corresponding monohydroxy androstenediones.
(6) Because of the relative selectivity of the fluorescence detection and the low potential required to oxidise the tetrahydropterins, all the oxidation species of the pterins may be measured in biological samples with minimal sample clean-up.
(7) This method allowed sequence determination using 100 pmol and 1 nmol of insulin B chain (oxidised) for 9 and 19 cycles respectively with thin-layer chromatographic identification of the fluorescent thiohydantoin amino-acid derivatives.
(8) The main conclusions are that the enzyme can efficiently oxidise bilirubin in microemulsions of low water content.
(9) Examination of the time course of addition of oxidised glutathione to translating lysates showed that efficient and correct disulphide pairing in newly biosynthesised prolactin occurred when the oxidant was present co-translationally, but much lower yields of correctly disulphide-bonded prolactin were obtained when the oxidant was added after translation and processing were complete.
(10) Its activity was sensitive to reduction with 2-mercaptoethanol and to the oxidising action of potassium periodate.
(11) Under the conditions of this study, it is possible that cuprous ion would be oxidised to the cupric form generating free radicals in the process.
(12) A high-performance liquid chromatographic method utilising fluorimetric detection of oxidised and reduced glutathione, following derivatization with dansyl chloride is described.
(13) Ejaculated boar spermatozoa treated in this way can oxidise external NADH via both a lactate-pyruvate shuttle and a malate-aspartate cycle; this oxidation is coupled to the phosphorylation of ADP.
(14) Pefloxacin is minimally absorbed by the gastrointestinal tract of the turtle Pseudemys scripta elegans and then N-oxidised and N-demethylated.
(15) D-pen oxidised rapidly to LMW metabolites and smaller amounts of D-pen-protein conjugate (D-pen-protein) in the air pouches of all animals.
(16) On the Apollo missions, lunar dust got everywhere – the crews inhaled it and got it in their eyes, and it wreaked mechanical havoc – and on Mars the dust is even more problematic, because it is highly oxidised, chemically reactive, electrically charged and windblown.
(17) Both semiquinone formation and reduction of b-562 showed transient kinetics due to a contribution of the reaction pathway via centre o when the iron-sulphur cluster and cytochrome c1 were oxidised.
(18) Damage occurring during ischaemia results in the release of oxidised proteins.
(19) The concentration of total glutathione (oxidised and reduced) in the kidney cortex and outer medulla was significantly higher than that of controls at 1 h following cisplatin administration.
(20) It was observed that, under standard assay conditions, whereas DS was incorporated as a substrate instead of oxidised glutathione (GSSG), the enzymes from both human liver extract and yeast sources failed to reduce the parent compound, implying that glutathione reductase perse do not reduce disulfiram.
Oxidize
Definition:
(v. t.) To combine with oxygen, or subject to the action of oxygen, or of an oxidizing agent.
(v. t.) To combine with oxygen or with more oxygen; to add oxygen to; as, to oxidize nitrous acid so as to form nitric acid.
(v. t.) To remove hydrogen from (anything), as by the action of oxygen; as, to oxidize alcohol so as to form aldehyde.
(v. t.) To subject to the action of oxygen or of an oxidizing agent, so as to bring to a higher grade, as an -ous compound to an -ic compound; as, to oxidize mercurous chloride to mercuric chloride.
Example Sentences:
(1) Compound Z has the properties expected of an oxidized MPT precursor.
(2) PMNs could be primed for PMA-triggered oxidative burst by muramyl peptide molecules (MDP) and two of its adjuvant active nonpyrogenic derivatives.
(3) Arterial oxyhaemoglobin saturation (SaO2) was monitored continuously during normal labour in 33 healthy parturients receiving pethidine and nitrous oxide for analgesia.
(4) The stopped-flow technique was used to measure the rate constants for the reactions between the oxidized forms of peroxidase with luminol and the following substrates: p-iodophenol, p-bromophenol, p-clorophenol, o-iodophenol, m-iodophenol, luciferin, and 2-iodo-6-hydroxybenzothiazole.
(5) The results show that in TMO-treated animals the time to the onset of convulsions, the time to the onset of NADH oxidation-reduction cycles, and the survival time were significantly longer than in the control group.
(6) Nitrous oxide, 60% (P less than 0.025) and 80% (P less than 0.02), caused significant increases in release of beta-endorphin.
(7) Uptake could be supported either by substrate oxidation or by adenosine 5'-triphosphate (ATP), and was inhibited in the former case by antimycin or cyanide, in the latter case by oligomycin, and in both cases by 2,4-dinitrophenol.
(8) Peripheral blood monocytes undergo an oxidative burst similar to that seen in neutrophils.
(9) Direct limiting effects of hypothermia on tissue O2 delivery and muscle oxidative metabolism as well as vasoconstriction and arteriovenous shunting associated with CPB procedures are likely to be involved in the above mentioned alterations of cell metabolism.
(10) EDRF is even more labile than prostacyclin, with a half-life of about 6 seconds, and it has recently been identified as nitric oxide.
(11) Both SAA and non-SAA enhanced ammonium excretion but only non-SAA enhanced organic anion excretion, an indicator of incomplete oxidation of organic acids.
(12) Despite the nearly anaerobic state of the ascites tumor fluid in vivo, cancer cells suspended in this fluid oxidized FFA at least as fast as they do in vitro under aerobic conditions.
(13) Steroid-treated steers showed a slight decline in synthesis which was significant (P less than 0.05) at week +5 post-implant while amino acid oxidation was significantly lower at weeks +2 (P less than 0.01) and +5 (P less than 0.05) compared with control animals.
(14) In the present work, we measured the inactivation of methionine synthase and the concurrent homocysteine export rate of two murine and four human cell lines during nitrous oxide exposure.
(15) These series were prepared by oxidation of the new hydroquinone precursors.
(16) Rhesus monkey BAT mitochondria (BATM) possess an uncoupling protein that is characteristic of BAT as evidenced by the binding of [3H]GDP, the inhibition by GDP of the high Cl- permeability or rapid alpha-glycerol-3-phosphate oxidation.
(17) Anaesthesia was achieved by a mixture of oxygen, nitrous oxide and fluothane without use of muscle relaxants.
(18) Endothelium-dependent relaxations to acetylcholine and endothelium-independent relaxations to nitric oxide were observed in rings from both strains during contraction with endothelin.
(19) Rapid reaction studies show the formation of an intermediate which is common to both the oxidation and inactivation pathways.
(20) During the carcinogens metabolism compounds are assumed to be formed, those are able to affect oxidative phosphorylation without forming any stable link with the respiratory chain components.