(1) In 11 of the 22 cells PAI-1 mRNA and in 6 of the 22 cells PAI-2 mRNA was found, pointing to a possible role of plasminogen activator inhibitors in the tumor-related plasminogen activator activity.
(2) We conclude that heparin plus AT III partially prevents the endotoxin-induced generation of PAI activity which seems to correlate with the reduced presence of fibrin deposits in kidneys and with a reduced mortality.
(3) Patients with inflammatory bowel disease showed decreased tissue-type plasminogen activator antigen release (t-PA Ag), no significant Von Willebrand antigen release (vWF Ag), and a residual plasminogen activator inhibitor activity (PAI activity) after venous occlusion.
(4) To exclude potential interactions with components of the extracellular matrix which contains binding sites for PAI-1, ligand binding to HepG2 cells in suspension was assessed.
(5) Plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of tissue-type plasminogen activator (t-PA) in plasma, is a serine proteinase inhibitor (serpin) that forms a 1:1 stoichiometric complex with its target proteinase leading to the formation of a stable inactive complex.
(6) Androgen receptor gene mutations were identified in nine CAIS and five PAIS subjects.
(7) Plasminogen activator inhibitor (PAI-I) rapidly inactivates tissue plasminogen activator (t-PA) and urokinase (UK) with nearly identical association rate constants.
(8) The increased PAI appears related to obesity and not diabetes per se.
(9) In the immunopurification of placental extract on anti-PAI-2 Sepharose, the eluate showed the expected reaction with Mab' PAI-2, and it also cross-reacted with anti-vitronectin serum.
(10) IL-1 beta decreased PAI-1 levels by 50% and stimulated PAI-2 levels sixfold.
(11) However, several areas showed a strong u-PA immunoreactivity, but no or low PAI-1 immunoreactivity.
(12) Added alone, H7 does not alter the basal junB or PAI-1 mRNA levels, the deposition of PAI-1 into the extracellular matrix, or the phosphorylation of RB in late G1 phase, suggesting that this inhibitor does not have a general nonspecific effect on the cell.
(13) While t-PA and u-PA levels were slightly lower than in adult controls, a significant decrease in PAI activity was demonstrated and no PAI-2 could be detected in fetal plasma.
(14) In recent clinical studies we have demonstrated that the level of plasma insulin correlated with that of PAI-1.
(15) VN associated with the ECM may confer retention and bioactivity to PAI-1, potentially facilitating both pericellular regulation of plasmin generation and the rapid hepatic clearance of plasminogen activators.
(16) Increases in PAI-1 mRNA levels were evident 1 h after growth factor treatment and were maximal after 4 h. PAI-1 mRNA levels were unaffected by cycloheximide treatment.
(17) To elucidate the mechanisms which govern expression of the PAI-1 gene, total cytoplasmic RNA was prepared from BAEs and analyzed by Northern blotting using a 1.3-kilobase (kb) human PAI-1 cDNA probe.
(18) It is presently unknown to what extent the treatment with acetylsalicylic acid (ASA) inhibits platelet PAI-1 release and if release inhibition has an effect on plasma PAI-1 levels.
(19) PAI was increased in 87% of these patients compared to the healthy controls.
(20) It exploded when leading daily El Pais published copies of account ledgers purportedly showing irregular payments to top party members including Rajoy, its leader since 2004.
Pas
Definition:
(n.) A pace; a step, as in a dance.
(n.) Right of going foremost; precedence.
Example Sentences:
(1) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(2) On dissected mucosa stained by the PAS-alcian blue whole-mount method the density and distribution of goblet cells in various parts of the middle ear was determined in 13 children, ranging in age from 9 days to 14 years.
(3) The results showed immunostaining to function equally well on frozen and routine sections, and to be superior to Alcian Blue and PAS with regard to morphological detail.
(4) The Personality Assessment System (PAS) is derived from certain subtest scores on any Wechsler test by rather simple calculations.
(5) Acidic mucus containing goblet cells have been revealed using Alcian blue staining when added to the PAS stained cells in conditions that have previously been shown to have reduced goblet cell population when assessed by PAS-haematoxylin staining.
(6) In neutrophilous peripheral blood leucocytes of healthy and leucotic cattle the PAS reaction attained the values of ++ to +++.
(7) In the untreated sections only glycogen revealed strong PAS reaction, most mucosubstances reacted weakly or not at all.
(8) After a three-month period of rigorous training, two PAs were assigned to the ICU.
(9) Vacuolar or intraluminal binding of peanut lectin was found to be more sensitive than PAS reaction for detecting early secretory activity.
(10) Paraphilias (PAs) and non-paraphilic sexual addictions (NPSAs) may be behaviors that share a common perturbation of central serotonin neuroregulation as a component of their pathophysiology.
(11) In addition, we should carefully interpret the muscle histochemistry, because histochemical stains including PAS might be fairly normal in the defects with second step glycolytic pathway.
(12) The PAS hyperchromaticity of basement membrane material and pericyte loss occurred throughout the retinal vasculature, while while the microaneurysms and complex lesions were limited to the capillaries of the central and paracentral retina.
(13) However, pulmonary arterial pressure was the same as controls at both day 8 and day 14 in MCTP-treated rats made moderately thrombocytopenic by cotreatment with PAS.
(14) These bodies were PAS-positive and stained with MT, and They had electron-dense complex structures.
(15) Thus, in man, tear fibrinolytic activity may depend primarily on a release of PAs from conjunctival tissue.
(16) Also in some areas, the cytoplasmic processes at the distal ends of the PAs invaded the predentin.
(17) The materials positive for the PAS and PTO reactions in alveolar septa are epithelial and endothelial basal laminas, which are nonargyrophilic.
(18) In some areas, the tumor shows a striking resemblance to Kaposi's sarcoma; criss-crossing fascicles of spindle cells are interspersed with narrow vascular spaces, but PAS-positive hyaline globules are absent.
(19) Within the PGE2-protected animals a significant increase was observed in the length of zones of the mucus-producing cells at the surface and in the foveolae (both PAS-positive and alcian-blue-positive cells).
(20) Serous granules were stained by toluidine blue, or by hematoxylin and eosin (H and E), but showed little or no reaction with periodic acid-Schiff (PAS) or Alcian blue.