(1) In 11 of the 22 cells PAI-1 mRNA and in 6 of the 22 cells PAI-2 mRNA was found, pointing to a possible role of plasminogen activator inhibitors in the tumor-related plasminogen activator activity.
(2) We conclude that heparin plus AT III partially prevents the endotoxin-induced generation of PAI activity which seems to correlate with the reduced presence of fibrin deposits in kidneys and with a reduced mortality.
(3) Patients with inflammatory bowel disease showed decreased tissue-type plasminogen activator antigen release (t-PA Ag), no significant Von Willebrand antigen release (vWF Ag), and a residual plasminogen activator inhibitor activity (PAI activity) after venous occlusion.
(4) To exclude potential interactions with components of the extracellular matrix which contains binding sites for PAI-1, ligand binding to HepG2 cells in suspension was assessed.
(5) Plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of tissue-type plasminogen activator (t-PA) in plasma, is a serine proteinase inhibitor (serpin) that forms a 1:1 stoichiometric complex with its target proteinase leading to the formation of a stable inactive complex.
(6) Androgen receptor gene mutations were identified in nine CAIS and five PAIS subjects.
(7) Plasminogen activator inhibitor (PAI-I) rapidly inactivates tissue plasminogen activator (t-PA) and urokinase (UK) with nearly identical association rate constants.
(8) The increased PAI appears related to obesity and not diabetes per se.
(9) In the immunopurification of placental extract on anti-PAI-2 Sepharose, the eluate showed the expected reaction with Mab' PAI-2, and it also cross-reacted with anti-vitronectin serum.
(10) IL-1 beta decreased PAI-1 levels by 50% and stimulated PAI-2 levels sixfold.
(11) However, several areas showed a strong u-PA immunoreactivity, but no or low PAI-1 immunoreactivity.
(12) Added alone, H7 does not alter the basal junB or PAI-1 mRNA levels, the deposition of PAI-1 into the extracellular matrix, or the phosphorylation of RB in late G1 phase, suggesting that this inhibitor does not have a general nonspecific effect on the cell.
(13) While t-PA and u-PA levels were slightly lower than in adult controls, a significant decrease in PAI activity was demonstrated and no PAI-2 could be detected in fetal plasma.
(14) In recent clinical studies we have demonstrated that the level of plasma insulin correlated with that of PAI-1.
(15) VN associated with the ECM may confer retention and bioactivity to PAI-1, potentially facilitating both pericellular regulation of plasmin generation and the rapid hepatic clearance of plasminogen activators.
(16) Increases in PAI-1 mRNA levels were evident 1 h after growth factor treatment and were maximal after 4 h. PAI-1 mRNA levels were unaffected by cycloheximide treatment.
(17) To elucidate the mechanisms which govern expression of the PAI-1 gene, total cytoplasmic RNA was prepared from BAEs and analyzed by Northern blotting using a 1.3-kilobase (kb) human PAI-1 cDNA probe.
(18) It is presently unknown to what extent the treatment with acetylsalicylic acid (ASA) inhibits platelet PAI-1 release and if release inhibition has an effect on plasma PAI-1 levels.
(19) PAI was increased in 87% of these patients compared to the healthy controls.
(20) It exploded when leading daily El Pais published copies of account ledgers purportedly showing irregular payments to top party members including Rajoy, its leader since 2004.
Rais
Definition:
(n.) Same as 2d Reis.
Example Sentences:
(1) But she says she is totally convinced that, as a public broadcaster, RAI has an ethical responsibility to start showing women in a more realistic light.
(2) The natural killer (NK) activity of peripheral blood mononuclear cells (PBMC) and lymphocytes with the capacity to form stable rosettes with neuraminidase-treated sheep red blood cells (E+) was studied in 28 previously untreated patients (11 at stage 0, 10 at stage I and 7 at stages II and III, according to Rai's classification) and 7 treated patients with B-cell chronic lymphocytic leukemia (B-CLL), all of them at stage 0 according to Rai's classification after treatment, and in 15 healthy controls.
(3) Fibromyalgia patients reported significantly higher levels of learned helplessness, assessed according to a rheumatology attitudes index (RAI), than patients with all other diseases, and scleroderma patients showed significantly lower RAI scores (P less than 0.05).
(4) RAI scanning is necessary postoperatively to determine the completeness of the surgical procedure and to detect residual or metastatic disease.
(5) As critics of Mr Berlusconi have been barred from the state broadcaster Radiotelevisione Italia, Mr Fo protests that artists are being "defenestrated" metaphorically from the RAI for the same reasons that leftwing dissidents were literally thrown out of police station windows in the 1970s when Mr Fo wrote his work Accidental Death of an Anarchist.
(6) The RAI indicates that our level is that of a developed country.
(7) The validity of the RAI was established in comparisons to the Arthritis Helplessness Index.
(8) The performances have also beaten viewing records at Rai Due public television, with audience shares of up to 15%.
(9) All patients had evidence of active disease, and the majority had advanced Rai stages.
(10) We conclude that even at early stages in the disease (12 patients were Rai stage 0 patients) when the total serum immunoglobulin levels are still near normal, the B cells respond poorly to B cell mitogens.
(11) The 5 tests performed were radioactive iodine uptake (RAI) at 2 and 24 hours, serum protein-bound iodine (PBI), thyroxine iodine by column, triiodothyronine absorption test, and serum cholesterol.
(12) Ninety-four percent of patients were in Rai stage III or IV with extensive marrow infiltration, massive splenomegaly, and cytopenias refractory to chemotherapy.
(13) Cholesterol and RAI determinations were extremely variable precluding any evidence of drug effect.
(14) These results rais the possibility that the carbodiimide-reactive protein may be present as an oligomer in the energy-transducing complex.
(15) Taking into account the value of the TTM score, patients of the intermediate risk group (stage II of Rai et al.)
(16) An empirical comparison of the proposed procedure to that of Rai and Van Ryzin demonstrates the improvement that can be achieved with the new procedure.
(17) During the same time, 303 patients received RAI therapy for Graves' disease and one (0.3%) has subsequently developed thyroid carcinoma.
(18) Discordant results (increased serum hormone levels and a low RAI) are found either in the usual forms of hyperthyroidism when large quantities of iodide are ingested, or in atypical forms of hyperthyroidism, including spontaneously resolving hyperthyroidism of subacute thyroiditis, thyrotoxicosis factitia, toxic struma ovarii, and functioning metastatic thyroid cancer.
(19) In one of these, the administration of thyroid-stimulating hormone (TSH) resulted in an appropriate increase in 24 hour RAI uptake from 14.9 to 37.1 per cent.
(20) In accordance with Rai's staging system the patients were distributed as follows: 0.29%; I, 20%; II, 25%; III, 13%; IV, 13%, and according to Binet's staging the distribution was: A, 55%; B, 21%; C, 24%.