(1) Blood acid-base status, serum electrolytes, and urine pH were examined in 64 infants and children with phenylketonuria (PKU) treated with three different low phenylalanine protein hydrolyzates (Aponti, Cymogran, AlbumaidXP) and two synthetic amino acid mixtures (Aminogran, PAM).
(2) This resulted in PAM and peritoneal macrophage lysosomal enzyme activity similar to control activity.
(3) [Tyr22] glucagon and [desHis1, Tyr22] glucagon were synthesized by an improved solid phase procedure on a Pam-resin.
(4) The role of IL-3 in the regulation of pulmonary alveolar macrophage (PAM) production was investigated.
(5) The mean size of human PAM was statistically greater than that for all other species evaluated, including nonhuman primates.
(6) Unlike bone marrow stem cells, PAM are unipotential and in vitro gave rise to only mononuclear phagocytes under the influence of IL-3.
(7) She really should have kept a dream journal, that Pam.
(8) The Lyt-2+ T-cells, and not the L3T4+ T-cells, were also found to be important for the ability of the intact L-PAM-cured MOPC-315 tumor bearers to reject a challenge with MOPC-315 tumor cells.
(9) The characteristics of the PAM hydroxylation process in vitro appear to reflect the efficiency of the extrarenal production of 1,25-(OH)2-D3 and the therapeutic efficacy of glucocorticoids in patients with sarcoidosis and disordered calcium metabolism.
(10) Similarly, PAM recovered from patients suffering from nonneoplastic interstitial lung disorders, i.e., sarcoidosis and hypersensitivity pneumonitis, were shown to be susceptible to the cytotoxic function provided by LAK cells.
(11) Routine electron microscopic examination on the same portion where SPLS were confirmed by PAM electron microscopy revealed amorphous, partially fibrous structures.
(12) Single-drug therapy did not significantly decrease numbers of PAM in lavage fluids, but combined therapy led to a 60 per cent (P less than 0.01) decrease in numbers of PAM.
(13) Similar dramatic cytotoxicity of L-PAM was apparent in time-dependent SCE response studies.
(14) The results demonstrate that a PAM is present in secretory granules of anglerfish islet tissue.
(15) We found that the chemotactic activity of the culture media supernatants from PAM recovered from oxygen-pretreated rats given E was 80% higher than that of media from PAM recovered from air-exposed rats given E. Neither PAM from air-exposed rats nor those from oxygen-exposed rats spontaneously released chemotaxins selective for other PAM.
(16) Insertion of either the entire 2.13-kb EcoRI-HindIII fragment or a 0.73-kb EcoRI-DraI subfragment encoding only the resolvase into the pAM beta 1-based cloning vector pMTL500E causes a significant enhancement of segregational stability (from 6.5 X 10(-2) to 3.0-4.0 X 10(-3) plasmid loss per cell per generation).
(17) The KFr cell line proved to be 3.1-fold resistant to L-phenylalanine mustard (L-PAM).
(18) The effects of 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC), 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU), and L-phenylalanine mustard (L-PAM) have been compared by using three i.p.
(19) In the present studies, high levels of peptidylglycine alpha-amidating monooxygenase (PAM), which catalyzes the formation of bioactive alpha-amidated peptides from their glycine-extended precursors, have been found in particulate fractions from bovine and rat heart atrium; only low levels of PAM activity were present in soluble fractions.
(20) PAM-A was still heterogeneous based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Pax
Definition:
(n.) The kiss of peace; also, the embrace in the sanctuary now substituted for it at High Mass in Roman Catholic churches.
(n.) A tablet or board, on which is a representation of Christ, of the Virgin Mary, or of some saint and which, in the Mass, was kissed by the priest and then by the people, in mediaeval times; an osculatory. It is still used in communities, confraternities, etc.
Example Sentences:
(1) By radioactive in situ hybridization (ISH) using a fragment from the murine Pax-1 paired box that is almost identical to the respective sequences from the cognate human gene HuP48 and fluorescence in situ hybridization (FISH) using a complete mouse Pax-1 cDNA, we have assigned the human homologue of murine Pax-1, the PAX1 locus, to chromosome 20p.
(2) Concurrent research has recently characterized Sp2H, a radiation induced mutation at the splotch (Sp) locus, and found alterations in the murine paired box gene, Pax-3, in homozygous Sp2H DNA.
(3) The chromosomal location of all novel Pax genes and of Pax-3 and Pax-7 has been determined and reveals that they are not clustered.
(4) Here we describe the paired boxes of three novel Pax genes, Pax-4, Pax-5, and Pax-6.
(5) Zebrafish pax[b](pax[zf-b]) is a member of the Pax gene family that is expressed in the presumptive posterior midbrain from the end of gastrulation and, at later stages, in other localized regions of the developing embryo.
(6) However, there are some differences in Pax-2 expression between the two species.
(7) These results support the Pax-6 homologue as a strong candidate for the AN2 gene.
(8) The chromosomal location and the mutation in the paired box of un mice in conjunction with Pax 1 gene expression in wild-type mice implicate a causative role of Pax 1 in generation of the vertebral column.
(9) Pax-3 encodes a 479 amino acid protein with an Mr of 56 kd containing both a paired domain and a paired-type homeodomain.
(10) The murine paired-box-containing gene 5, Pax-5, is highly homologous to two other Pax genes, Pax-2 and Pax-8.
(11) The Pax-2 expression domain in the prospective brain of E8 mouse embryos has not been described previously.
(12) Here we describe a zebrafish (Brachydanio rerio) paired box-containing clone, pax[zf-a], which is clearly distinct from reported vertebrate Pax genes.
(13) pax-6 expression appears during processes when cell-to-cell signalling is thought to be important, for example during induction of the eye and regionalization of the spinal cord and brain, suggesting that it may be one component mediating the response to inductive interactions.
(14) We describe the isolation and characterization of Pax-3, a novel murine paired box gene expressed exclusively during embryogenesis.
(15) Among the genes thought to be involved in patterning the nervous system are a family of developmentally regulated paired box-containing (Pax) genes.
(16) However, normal v-Myb- and c-Myb-expressing CNR cells all express the pax-QNR gene, a newly described paired and homeobox-containing gene specifically expressed in the neuroretina.
(17) The brain, the optic stalk, the auditory vesicle, the pronephros, and single cells in the spinal cord and the hindbrain express Pax-2 in both species.
(18) Mutations in Pax-6 have been described previously in Small eye, the proposed mouse model for aniridia.
(19) To date five murine paired box-containing genes (Pax genes) have been described and one, Pax-1, has been associated with the developmental mutant phenotype undulated.
(20) However, a region of homology to the N-terminal half of paired-type homeoboxes is detected C-terminal to the pax[zf-b] paired domain.