(n.) A paroxysm of extreme pain or anguish; a sudden and transitory agony; a throe; as, the pangs of death.
(v. t.) To torture; to cause to have great pain or suffering; to torment.
Example Sentences:
(1) If Reading win promotion in the Championship play-off final against Swansea City on Monday – and, to be fair, even if they don't – a lot of managers will probably be feeling a pang of regret.
(2) Administration of furosemide induced marked increases in PRA, Ang I-ir, PAng II-ir and CSF Ang II-ir, however, neither plasma nor CSF angiotensinogen was changed.
(3) Elevation of sodium intake suppressed pANG II to minimal levels in nonpregnant sheep, but to only 25% of the control level in pregnant sheep.
(4) But this week, the committee rooms in Hove's brutalist town hall witnessed the birth pangs of a monstrosity which may yet dwarf any of the hideous items on Jenkins's list.
(5) I look around and everyone else seems to have invited Barbie into their children's toy chests without a pang of guilt.
(6) in the accompanying paper (L. T. Haber, P. P. Pang, D. I. Sobell, J.
(7) The influence of nifedipine treatment on plasma (PV) and extracellular fluid volume (ECV), the ratio of plasma volume to interstitial fluid volume (PV:IF), glomerular filtration rate (GFR), renal clearances of Na+ and K+, plasma concentrations of renin (PRC), angiotensin II (pANG II), aldosterone (pAldo), adrenaline (PA) and noradrenaline (PNA) were studied in 18 consecutive patients with essential hypertension.
(8) A disgraceful display in any civilized society to be sure, but for fight fans of a certain vintage it was hard to not feel a pang of nostalgia.
(9) In spite of significant suppression of PRA and PAng I-ir, there were no significant changes in either plasma or CSF angiotensinogen.
(10) Immunological data revealed that the 42- and 43-kDa proteins were related to alpha-subunits of the Gq class recently purified from brain (Pang, I.-H., and Sternweis, P. C. (1990) J. Biol.
(11) This difference was more evident for the Yao Pang locus.
(12) "I'd be fibbing if I said I didn't have a pang for that – the amazing five days [of coalition talks that followed the election] and deals stuck together and all the rest of it.
(13) Across the contralateral kidney the veno-arterial differences in PRC and pANG II were both close to zero, while negative differences in pANG II indicated the removal of ANG II.
(14) He has been burdened with them for a decade and more, first satisfying the hunger pangs wrought by 77 years of waiting for someone to emulate Fred Perry, then leading this team here to smash more Perry history and win the Cup for Great Britain for the first time since 1936.
(15) Also, the inverse relationship of sodium intake and pANG II was blunted, suggesting a reduced role for ANG II in the maintenance of renal function during pregnancy.
(16) Previous studies in the once-through perfused rat liver preparation have shown that the techniques of normal and retrograde delivery of substrate and computer simulation of enzyme distributions along the sinusoidal flow path in liver were useful in delineating the relative distributions of sulfation and glucuronidation activities for harmol metabolism (Pang et al., J. Pharmacol.
(17) said Pang Jinhua, mother-in-law of lawyer Teng Biao, who has been missing since mid-February.
(18) Rather the zonal localization of metabolizing activities [a periportal sulfation, evenly distributed glucuronidation, and perivenous hydroxylation system (Xu and Pang, J. Pharmacokinet.
(19) River flows had however been boosted temporarily – the Pang in Berkshire, which had been completely dry, was flowing again thanks to runoffs from drenched fields.
(20) Veno-arterial differences in pANG I across the affected kidney in patients with lateralization of the renin secretion indicated release of angiotensin I (ANG I) in considerable amounts.
Sharp
Definition:
(superl.) Having a very thin edge or fine point; of a nature to cut or pierce easily; not blunt or dull; keen.
(superl.) Terminating in a point or edge; not obtuse or rounded; somewhat pointed or edged; peaked or ridged; as, a sharp hill; sharp features.
(superl.) Affecting the sense as if pointed or cutting, keen, penetrating, acute: to the taste or smell, pungent, acid, sour, as ammonia has a sharp taste and odor; to the hearing, piercing, shrill, as a sharp sound or voice; to the eye, instantaneously brilliant, dazzling, as a sharp flash.
(superl.) High in pitch; acute; as, a sharp note or tone.
(superl.) Raised a semitone in pitch; as, C sharp (C/), which is a half step, or semitone, higher than C.
(superl.) So high as to be out of tune, or above true pitch; as, the tone is sharp; that instrument is sharp. Opposed in all these senses to flat.
(superl.) Very trying to the feelings; piercing; keen; severe; painful; distressing; as, sharp pain, weather; a sharp and frosty air.
(superl.) Cutting in language or import; biting; sarcastic; cruel; harsh; rigorous; severe; as, a sharp rebuke.
(superl.) Of keen perception; quick to discern or distinguish; having nice discrimination; acute; penetrating; sagacious; clever; as, a sharp eye; sharp sight, hearing, or judgment.
(superl.) Eager in pursuit; keen in quest; impatient for gratification; keen; as, a sharp appetite.
(superl.) Keenly or unduly attentive to one's own interest; close and exact in dealing; shrewd; as, a sharp dealer; a sharp customer.
(superl.) Composed of hard, angular grains; gritty; as, sharp sand.
(superl.) Steep; precipitous; abrupt; as, a sharp ascent or descent; a sharp turn or curve.
(superl.) Uttered in a whisper, or with the breath alone, without voice, as certain consonants, such as p, k, t, f; surd; nonvocal; aspirated.
(adv.) To a point or edge; piercingly; eagerly; sharply.
(adv.) Precisely; exactly; as, we shall start at ten o'clock sharp.
(n.) A sharp tool or weapon.
(n.) The character [/] used to indicate that the note before which it is placed is to be raised a half step, or semitone, in pitch.
(n.) A sharp tone or note.
(n.) A portion of a stream where the water runs very rapidly.
(n.) A sewing needle having a very slender point; a needle of the most pointed of the three grades, blunts, betweens, and sharps.
(n.) Same as Middlings, 1.
(n.) An expert.
(v. t.) To sharpen.
(v. t.) To raise above the proper pitch; to elevate the tone of; especially, to raise a half step, or semitone, above the natural tone.
(v. i.) To play tricks in bargaining; to act the sharper.
(v. i.) To sing above the proper pitch.
Example Sentences:
(1) Basal 20 alpha DHP levels remained low until a sharp rise at mid pro-oestrus.
(2) Whole-virus vaccines prepared by Merck Sharp and Dohme (West Point, Pa.) and Merrell-National Laboratories (Cincinnati, Ohio) and subunit vaccines prepared by Parke, Davis and Company (Detroit, Mich.) and Wyeth Laboratories (Philadelphia, Pa.) were given intramuscularly in concentrations of 800, 400, or 200 chick cell-agglutinating units per dose.
(3) Gonadectomy of females was accompanied by changes in the activity of individual HAS links in different direction--some reduction of ACTH in the hypophysis, a sharp and significant fall of the peripheral blood glucocorticoid level and a marked significant elevation of hydrococortisone production in the adrenal cortex in vitro.
(4) The University of the Arts London and Sunderland, Sheffield Hallam, Manchester Met and Leeds Met university have also experienced sharp declines in applications.
(5) A sharp decrease in oxygen uptake occurred in Neurospora crassa cells that were transferred from 30 degrees C to 45 degrees C, and the respiration that resumed later at 45 degrees C was cyanide-insensitive.
(6) In contrast to findings in the rat and dog, no sharp drop but a gradual fall in CLi was observed at decreasing FENa values down to 0.02%.
(7) A more specific differentiation, as indicated by the sharp increase in GAD levels which was concurrent with an increase in interneuronal contacts, lagged behind the initial growth.
(8) It appears that the decline in plasma IGF-I lags considerably behind the sharp fall in plasma GH levels and expression of hepatic IGF-I mRNA.
(9) Supplementation of Mg resulted in a sharp increase in serum PTH level with a rapid disappearance of the dissociation between the two immunoassays of PTH.
(10) A.CA animals were extremely susceptible, showing a sharp and sustained increase in parasitemia starting on day 12, followed by death no later than day 15 post-inoculation.
(11) There was a sharp transition with actin nearly saturated with S1: when the S1 to actin ratio was low, the kinetics were fast (K1 greater than 300 microM, k2 greater than 40 s-1); when it was high, they were slow (K1 = 14 microM, k2 = 2 s-1).
(12) Low calcium causes an increase in optimum frequency, a decrease in current threshold, and an increase in sharpness of tuning in both real axons and axons computed according to the Hodgkin-Huxley formulation; high calcium causes opposite effects.
(13) The Tea Party movement has turned climate denial into a litmus test of conservative credentials – and that has made climate change one of the most sharp divisions between Obama and Romney.
(14) The presence in lamprey kidney of a loop which is similar to Henle's loop in mammals and birds indicates that the development of the system of osmotic concentration conditioned by the formation in the kidney of the medulla and from a sharp increase in renal arterial blood supply.
(15) There is no longer a sharp dividing line between working and rentiering.
(16) We are going to see a sharp fall unless sellers hold the sector up by making aggressive offers.
(17) A sharp increase in the intensity of lipids biochemiluminiscence and decrease in the tissue homogenates biochemiluminiscence were observed during the period of progressive tumour growth on the 6-8 days following introduction of the virus.
(18) By no means is this a new theme, but it has taken on an added sharpness and urgency after the conferences.
(19) The blood lymphocytes were small with scanty cytoplasm, densely condensed nuclear chromatin, and deep clefts originating in sharp angles from the nuclear surface.
(20) In sharp contrast, the coverage provided by the various mainstream news channels and newspapers not only seems – with some exceptions – unresponsive and stilted, but often non-existent.