(n.) An alkaloid found in opium. It has a weaker therapeutic action than morphine.
Example Sentences:
(1) Isoproterenol [IC 50 approximately 1 X 10(-9) M], prostaglandins, dibutyryl cyclic AMP [IC 50 approximately 2 X 10(-5) M], papaverine, theophylline and 5' AMP were inhibitory in the assay, whereas dibutyryl cyclic GMP and the cholinergic stimulator carbamylcholine either stimulated or had no effect on mitosis.
(2) Our work demonstrates that the systemic availability or papaverine can be markedly affected by product formulation.
(3) The amplitude was 15-70% as large as the tonic component of the K-contracture induced by 40 mM K. Theophylline (10 mM), 0.1 mM papaverine and 1 microM isoprenaline nearly abolished, and 1 mM cAMP partly depressed the tonic contraction of K-contracture, whereas the tonic contraction induced by the test solution was unaffected.
(4) In these studies, it is shown that increasing concentrations of carbamylcholine (carbachol) result in a shift to the right of the dose-response curves to (-)-isoproterenol and (-)-soterenol and a reduction of the maximum degree of relaxation produced by these agonists relative to that produced by papaverine.
(5) Similar results were obtained with vincamine (Vi) but vincamine's bronchoconstriction was not completely inhibited by papaverine.
(6) Pressure above and below the stenosis was measured intra-arterially and flow related measurements were made at rest and during reactive hyperaemia in the dog, and following papaverine administration in patients.
(7) Total bacterial counts, nitrate-reducing bacteria and nitrite concentration were determined in fasting gastric juice before and after 4 weeks of treatment with a strong or with a mild antacid drug, a placebo preparation and the spasmolytic agent papaverine which is known to inhibit gastric evacuation.
(8) To assess the role of hydrostatic pressure in edema formation, we compared lung permeability-surface area products (PS) in papaverine-treated lungs given either protamine alone or PAF + protamine and tested the effect of mechanical elevation of Pmv on protamine-induced lung edema.
(9) 50 patients were treated eith carbocromen and 50 with papaverine as controls.
(10) Aminophylline and caffeine can mimic this effect; however, papaverine and 1-methyl-3-isobutylxanthine, at concentrations inhibitory to phosphodiesterase, are without effect on glucocorticoid receptor binding to DNA.
(11) The effects on these kinetics of a joint administration of Papaverine are considered.
(12) The action of papaverine was nearly similar in control and irradiated groups.
(13) In both cell cultures, changes in cyclic nucleotide levels were first observed at 6 h after viral inoculation and were maximal at 12 h. In human fibroblasts, the addition of theophylline, dibutyryl cAMP, or papaverine (cAMP-enhancing compounds) decreased significantly the yield of HSV-1, whereas the addition of insulin or dibutyryl cGMP (cGMP-enhancing compounds) increased the viral yield.
(14) In the presence of 10(-3) M-papaverine higher doses of noradrenaline evoked the non-selective cation current in some portal vein cells.
(15) During constrictions caused by norepinephrine, methylene blue significantly inhibited the renal vasodilatations caused by tertatolol, acetylcholine, papaverine and nitroglycerin but not those caused by atrial natriuretic factor.
(16) The average rates of development of the contractile and relaxation phases and their relative dependence in the acetylcholine contractile effect, after treatment with papaverine, prostaglandines E1 and F2 alpha and BaCl2, are tested on longitudinal and circular smooth muscles of guinea-pig caecum.
(17) A mixture of Hexabrix and papaverine produced a white crystalline precipitate.
(18) Papaverine is useful in vein preparation; it protects the endothelium and smooth muscle cells in the intima and media and prevents leukocyte infiltration and medial fibrosis.
(19) Nifedipine and superoxide dismutase induced small but significant relaxations in phorbol ester-contracted vessels; however, blood vessels contracted with phenylephrine and phorbol ester relaxed completely with papaverine.
(20) Bencyclan (Fludilat), used therapeutically as a vasodilator drug, exerts a distinct negative inotropic and chronotropic action on myocardium, in contrast to papaverine.
Spasm
Definition:
(v. t.) An involuntary and unnatural contraction of one or more muscles or muscular fibers.
(v. t.) A sudden, violent, and temporary effort or emotion; as, a spasm of repentance.
Example Sentences:
(1) The generally accepted hypothesis is a coronary spasm but a direct cardiotoxicity of 5-FU cannot be.
(2) Oculomotor paresis with cyclic spasms is a rare syndrome, usually noticeable at birth or developing during the first year of life.
(3) The ophthalmic headache's crisis is caused, in fact, by a spasm of convergence on an unknown exophory of which the amplitude of fusion is satisfying, and the presence of which can only be seen with test under screen.
(4) The present case indicates that the possibility of osseous spines impinging on the facial nerve should be considered in all cases of facial spasm.
(5) The coronary arteriography reveals a spasm in the normal left anterior descendens artery.
(6) Increasing awareness of disorders such as coronary arterial spasm, functional impairment of subendocardial blood flow and the possible role of variant patterns of anatomic distribution of the coronary arterial tree, will provide a better understanding of their significance as determining or contributing factors in patients with the anginal syndrome.
(7) Thus one may speculate that endothelin plays a role in the coronary spasm which has been shown in patients with angina pectoris.
(8) in 1937, the arterial spasm may have occurred at the time of cerebral embolism.
(9) Coronary spasm was provoked by ergonovine maleate in four of 12 patients in group A (33%) and in three patients in group B (18%).
(10) In 2 cases, sublingual nitroglycerin failed to completely relieve the spasm.
(11) Furthermore, an association of tiapride-corticoids was effective in treating post-anaesthetic spasm of the glottis.
(12) Case histories of two patients with hypertensive LES and normal peristalsis in the body of the esophagus are contrasted to that of a patient with a hypertensive LES and diffuse esophageal spasm.
(13) Whether they affect ureteral motility in vivo or whether they can counteract ureteral spasm associated with ureteral stones have not been established.
(14) Thrombotic occlusion, in association with varying degrees of plaque disruption and coronary artery spasm, represents the major cause of acute myocardial infarction (AMI).
(15) The patients with spasm on top of a fixed organic lesion underwent a successful aorto-coronary bypass graft together with resection of the pre- and sub-aortic nerve plexus.
(16) In vitro tests with isolated trachea or ileum of guinea pigs show that flupirtine possesses no or very weak antagonism against histamine-induced spasms.
(17) The spasms were inhibited by gallopamil (100 nM) and diltiazem (1 microM).
(18) Indeed this procedure is the only one which can act in a fitted manner on muscular spasms responsible of more than 60% of convergent squints.
(19) Such an exercise response should suggest significant fixed coronary stenosis in addition to coronary spasm.
(20) Evidence is provided for the concept of enlarged spasms (phenomenon of the spastic dominant) common to peptic ulcer.