(a.) Having the highest rank or jurisdiction; superior to all others; chief; supreme; preeminent; as, a paramount duty.
(n.) The highest or chief.
Example Sentences:
(1) The results of our phenotypic and functional testing of unmodified GIC (no enzyme treatment, no additional culture with or without interleukin 2), show that T cells, especially OKT8+ cells, are of paramount importance in the mechanism of this type of acute irreversible rejection of human renal allografts (i.e., to the point of allograft rupture), but other potential effector mechanisms are also present in situ.
(2) mechanisms of quality control, including extensive programs of orientation, inservice, and utilization review, are paramount in achievement of success.
(3) In the Labour party over the past two decades, the leader has become paramount, directing not just his own staff, but Labour headquarters.
(4) Urinalysis, a simple front-line test, is of paramount importance in the evaluation and management of the patient with urinary tract infection.
(5) Since the primary diagnosis of this condition is almost invariably based on cytologic observations, the diagnostic criteria are of paramount importance.
(7) They emphasize that life-time diagnosis of pericardial mesothelioma is of paramount importance because rational chemotherapy permits prolongation of the patient's survival.
(8) The paramount feature revealed by immunohistological double marker analyses was the intimate association of myoid cells (antigen producing) with interdigitating reticulum cells (potentially antigen presenting cells), both of which were surrounded by T3+ lymphocytes in thymus medulla.
(9) The latter method is suitable for routine use in renography when accuracy is not of paramount importance.
(10) These preliminary data confirm the paramount importance of cellular immunity in controlling neoplasias.
(11) The use of zinc nitrate is favored if toxicological considerations are paramount, but ninhydrin development has to be carefully controlled if optimal results are to be obtained.
(12) The functional end result is of paramount importance.
(13) The symptoms of anaemia and indigestion appear to be paramount in making an early diagnosis, and negative barium meal studies should not be accepted when these two symptoms are present.
(14) These results might be of paramount significance in developing the detection method for HCV infection and in preparing HCV vaccine.
(15) Correct diagnosis and understanding of its pathogenesis is paramount in order to apply definite surgical treatment.
(16) Regardless of the technique utilized it remains paramount that the surgeon plan the initial procedure with great care as each failure results in diminished blood supply to the graft bed and makes subsequent procedures less likely to succeed.
(17) The work presented here gives a description, analysis and discussion of the effect of organic loading which is a paramount parameter of the performance of RBC's.
(18) The intended application is to assist in treatment selection during phase II trials, especially with rapid responses and when the disease involved is serious enough that design-motivating ethical considerations become paramount.
(19) Although the precise mechanism of thrombosis is incompletely known, the recognition of this type of dementia is of paramount importance as it is a potentially treatable condition.
(20) An understanding of the pathophysiology of anaphylaxis, the most serious of the allergic disorders, is paramount for its diagnosis.
Prior
Definition:
(a.) Preceding in the order of time; former; antecedent; anterior; previous; as, a prior discovery; prior obligation; -- used elliptically in cases like the following: he lived alone [in the time] prior to his marriage.
(a.) The superior of a priory, and next below an abbot in dignity.
Example Sentences:
(1) Combination therapy was most effective in patients receiving HCTZ prior to enalapril.
(2) These results indicated that the PG determination was the most accurate predictor of fetal lung well-being prior to birth among the clinical tests so far reported.
(3) Prior to oral feeding, little or no ELA was detected in stools and endotoxinemia was ascertained in only six of 45 infants (13%).
(4) Release of 51Cr was apparently a function of immune thymus-derived lymphocytes (T cells) because it was abrogated by prior incubation of spleen cells with anti-thymus antiserum and complement but was undiminished by passage of spleen cells through nylon-wool columns.
(5) Prior to joining JOE Media, Will was chief commercial officer at Dazed Group, where he also sat on the board of directors.
(6) The secretion of GH as measured by increased plasma level, in response to oral administration of 500 mg L-dopa or 30 min-infusion of arginine, was not modified by prior intravenous administration of 200 micrograms GH-releasing hormone (GHRH).
(7) In a double-blind, crossover-designed study, 9 male subjects (age range: 18-25 years) received 25 mg orally, four times per day of either S or an identically-appearing placebo (P) 2 d prior to and during HA.
(8) The remainder of the radioactivity appeared chromatographically just prior to the bisantrene peak, indicating that compounds more polar than the parent were present as transformation products.
(9) The number of gastrin-immunoreactive cells actually decreases just prior to weaning but then increases at and after, weaning.
(10) Sephadex LH-20 column chromatography was used for the separation of the steroid prior to assay.
(11) Blood samples were collected from an antecubital vein at sea level (S1), in a base camp at 1515 m prior to the summit ascent (S2), on the summit at 3285 m after 6.5 hours of climbing (S3), at base camp immediately after the descent (S4), and at sea level following a trail descent from the base camp (S5).
(12) A direct radioimmunoassay method using highly specific antisera without prior deconjugation has been developed for determination of estradiol 17-glucuronide and estriol 16-glucuronide in human plasma.
(13) Multiple operations were done in 7 patients prior to the appropriate diagnosis and treatment.
(14) Symptoms consistent with major affective disorder were present in one half and depressive spectrum diagnoses were made in one fourth of the cases prior to final diagnosis.
(15) In the genitourinary clinic setting, clinical diagnosis prior to biopsy was found frequently to be inaccurate.
(16) None of these were apparent on prior roentgenograms of the chest.
(17) It has a poor prognosis prior to the current combined treatment of surgical ablation, radiation to the surgical field, and chemotherapy for microscopic metastases.
(18) The flow cytometric measured DNA content (i.e., DNA index), S-fractions, and histopathologic malignancy grades were studied for ninety uterine cervical squamous cell carcinomas using tissue biopsies taken prior to radiotherapy.
(19) The consequences of proved hypersensitivity in patients with metal-to-plastic prostheses, either present prior to insertion of the prosthesis or evoked by the implant material, are not known.
(20) However, the effect of prior jaw motion and the effect of the recording site on the EMG amplitudes and on the vertical dimension of minimum EMG activity have not been documented.