(a.) Having the highest rank or jurisdiction; superior to all others; chief; supreme; preeminent; as, a paramount duty.
(n.) The highest or chief.
Example Sentences:
(1) The results of our phenotypic and functional testing of unmodified GIC (no enzyme treatment, no additional culture with or without interleukin 2), show that T cells, especially OKT8+ cells, are of paramount importance in the mechanism of this type of acute irreversible rejection of human renal allografts (i.e., to the point of allograft rupture), but other potential effector mechanisms are also present in situ.
(2) mechanisms of quality control, including extensive programs of orientation, inservice, and utilization review, are paramount in achievement of success.
(3) In the Labour party over the past two decades, the leader has become paramount, directing not just his own staff, but Labour headquarters.
(4) Urinalysis, a simple front-line test, is of paramount importance in the evaluation and management of the patient with urinary tract infection.
(5) Since the primary diagnosis of this condition is almost invariably based on cytologic observations, the diagnostic criteria are of paramount importance.
(6) José Manuel Barroso, the re-elected commission chief, stressed that rather than being seen as president of Europe, or Europe's paramount leader, the new post should be confined to the European council, which groups national governments from the member states.
(7) They emphasize that life-time diagnosis of pericardial mesothelioma is of paramount importance because rational chemotherapy permits prolongation of the patient's survival.
(8) The paramount feature revealed by immunohistological double marker analyses was the intimate association of myoid cells (antigen producing) with interdigitating reticulum cells (potentially antigen presenting cells), both of which were surrounded by T3+ lymphocytes in thymus medulla.
(9) The latter method is suitable for routine use in renography when accuracy is not of paramount importance.
(10) These preliminary data confirm the paramount importance of cellular immunity in controlling neoplasias.
(11) The use of zinc nitrate is favored if toxicological considerations are paramount, but ninhydrin development has to be carefully controlled if optimal results are to be obtained.
(12) The functional end result is of paramount importance.
(13) The symptoms of anaemia and indigestion appear to be paramount in making an early diagnosis, and negative barium meal studies should not be accepted when these two symptoms are present.
(14) These results might be of paramount significance in developing the detection method for HCV infection and in preparing HCV vaccine.
(15) Correct diagnosis and understanding of its pathogenesis is paramount in order to apply definite surgical treatment.
(16) Regardless of the technique utilized it remains paramount that the surgeon plan the initial procedure with great care as each failure results in diminished blood supply to the graft bed and makes subsequent procedures less likely to succeed.
(17) The work presented here gives a description, analysis and discussion of the effect of organic loading which is a paramount parameter of the performance of RBC's.
(18) The intended application is to assist in treatment selection during phase II trials, especially with rapid responses and when the disease involved is serious enough that design-motivating ethical considerations become paramount.
(19) Although the precise mechanism of thrombosis is incompletely known, the recognition of this type of dementia is of paramount importance as it is a potentially treatable condition.
(20) An understanding of the pathophysiology of anaphylaxis, the most serious of the allergic disorders, is paramount for its diagnosis.
Utmost
Definition:
(a.) Situated at the farthest point or extremity; farthest out; most distant; extreme; as, the utmost limits of the land; the utmost extent of human knowledge.
(a.) Being in the greatest or highest degree, quantity, number, or the like; greatest; as, the utmost assiduity; the utmost harmony; the utmost misery or happiness.
(n.) The most that can be; the farthest limit; the greatest power, degree, or effort; as, he has done his utmost; try your utmost.
Example Sentences:
(1) Differentiation between these two types of lesions is of utmost importance since the surgical approach will be different.
(2) In order to achieve guineaworm eradication in 1990s, the Guineaworm Eradication Programme (GWEP) should operate with utmost efficiency; and needs to be concurrently evaluated for timely corrective measures.
(3) The pH of the extraction buffer was of the utmost importance, since it was demonstrated that a pH greater than 5 would give rise to false signals.
(4) Whereas live Toxoplasma "vaccines" may be effective in sheep and goats, the eventual preparation of a killed vaccine capable of inducing long-term protection is of the utmost importance.
(5) Despite advantages and technological advances in the techniques of dental casts and ceramics attachment to metal, plastic materials for crown and bridge facetting are still of utmost importance for prosthetic procedures.
(6) * * * Stalker, meanwhile, having made his decision, pursued Tape 042 with the utmost vigour.
(7) Early recognition of the major peroxisomal disorders in which functional peroxisomes are virtually absent, leading to a generalised impairment of peroxisomal functions, is of utmost importance, as this will enable the prenatal diagnosis of these severe diseases in future pregnancies.
(8) It is incumbent on the US, Britain and France to do their utmost to help the country win the peace.
(9) We conclude that the stimulation of Pk-C is of utmost importance for OL regeneration.
(10) However, it is of utmost importance that the institutes in "Eastern Europe" establish these standards as soon as possible in order to be competitive and to be able to join research-projects with "Western" universities - a necessary source of income.
(11) A consultant knowledgeable in the problems of the spinal cord injured can be of utmost benefit especially in the labor and delivery process.
(12) Intubation, artificial ventilation, fluid administration (electrolyte-solution) are of utmost importance for their survival and to reduce the frequency of major complications.
(13) As such, we treat any such allegations with the utmost seriousness and we will be contacting Jess to offer to discuss her concerns in full.” Sutton, in his own statement, said: “I wholeheartedly deny that I said or did anything other than act with complete professionalism in my dealings with Jess.
(14) Incidence of renal hydatid cyst is rare and its diagnosis should be made with the utmost care and after subjecting the patient to intensive investigations to exclude other pathologies.
(15) Both numbering systems initiate at the utmost 5' terminus of mRNA synthesis; this 5' initiator nucleotide is assigned 1.
(16) He fulfilled a difficult role in a progressive and compassionate way … he has done his utmost to transform the CPS's record on rape and domestic violence, delivering improved conviction rates for both.
(17) This is of the utmost importance, both epidemiologically and from the individual patient's point of view, and is a prerequisite in preventing the spread of HIV infection.
(18) This may be partly due to excessive patient fear according to the general belief that the heart is the utmost important part of life.
(19) Vaginal scanning of the ovaries and the uterus is a diagnostic and monitoring tool of utmost importance in assisted conception.
(20) In severe cases where hemorrhages play so large a role, albeit infrequently, the specific action of iron in interference with coagulation mechanisms is of the utmost importance.