(1) To study the role of the PENK gene in opioid related processes, an antisense sequence of PENK gene was subcloned into pSVL SV 40 late promoter expression vector and stably transfected into NG 108-15 cells, which contain opioid receptors.
(2) From steady-state kinetics half-life estimates of 9.6 h for PPenk mRNA and 14.7 h for Penk peptide were obtained.
(3) The Penk Combat Exposure scale did not separate the groups.
(4) "I was half expecting to see him on Songs of Praise," Penk added.
(5) Clinical observations and empirical evidence suggest that, among Vietnam combat veterans, Blacks are more maladjusted than Whites (e.g., Parsons, 1985; Penk et al., 1985).
(6) Penk, who now owns the Oldham-based local radio station 96.2 Revolution, said he was "appalled" at the "sheer scale of this unfair cross-promotion".
(7) "In these hard times it is difficult enough for the large, quasi-national commercial radio brands to compete with such unfair 'free' publicity," said Penk.
(8) The Penk Combat Intensity scale, which was correlated highly with the Keane scale, differentiated the PTSD-positive patients from both the normals and the PTSD-negative patients, but with less differentiating power (omega 2'S = .07 and .08).
(9) Facebook Twitter Pinterest The former Capital and Virgin Radio DJ Steve Penk has written to the BBC Trust to complain about the "excessive" and "gratuitous" cross-promotion of Chris Evans's new Radio 2 breakfast show on television.
(10) An increase in PENK mRNA levels has been also observed in cultures treated with 8-Br-cAMP, phorbol 12-myristate-13-acetate (TPA), or dexamethasone.
(11) Thus, activation of Penk gene expression upon neurotransmitter challenge is suggested to be due to an enhanced transcriptional activity of the gene mediated by de novo synthesized protein (-like) factors.
(12) We suggest that both the increased PENK message and the unchanged levels of free Met-enkephalin may be the result of compensatory mechanisms induced by translational inhibition by antisense, although the underlying processes remain to be determined.
(13) Penk was also critical of what he called the "placement" of Evans on BBC TV shows including Friday Night with Jonathan Ross, the One Show and the Andrew Marr Show.
(14) Unilateral adrenal denervation resulted in a rapid decrease in PPenk mRNA levels of 54% after 2 days, and by 11 days 90% of Penk mRNA had disappeared.
(15) Penk claimed the Evans trail broke the BBC Trust's own policy on cross-promotion.
(16) However, incubation of the cultures with the opioid agonist etorphine or the antagonist naltrexone did not alter PENK gene expression, suggesting that there is not feedback control of opioids on PENK biosynthesis in these cells.
(17) In this study we identified the potential sites of synthesis by localizing the mRNA coding for PENK in the rat pituitary gland using in situ hybridization histochemistry.
(18) Depolarization with potassium chloride (KCl) or veratridine increases the expression of PENK mRNA in a time-dependent fashion, with a maximal increase of sixfold.
(19) The proenkephalin A (PENK) gene codes for several opioid peptides, including Met-enkephalin, an endogenous ligand of opioid receptors.
(20) After an initial lag phase (with no major alterations) Penk mRNA increased markedly between 6 and 12 h followed by a slower, steady increase up to 48 h. The nicotinic receptor antagonist tubocurarine (4 x 10(-7) M) and the Ca2+ channel blocker D600 (10(-5) M) prevent the subsequent rise of Penk mRNA levels after challenge with nicotine, when given within the lag phase (0-6 h), suggesting the need of continuous receptor occupation and Ca2+ entry for induction of gene expression.
Pens
Definition:
(n.) pl. of Penny.
Example Sentences:
(1) Why bother to put the investigators, prosecutors, judge, jury and me through this if one person can set justice aside, with the swipe of a pen.
(2) And if the Brexit vote was somehow not respected by Westminster, Le Pen could be bolstered in her outrage.
(3) Auranofin (AF), D-penicillamine (D-pen) and thiola are prescribed as disease-modifying drugs in the treatment of rheumatoid arthritis (RA).
(4) It’s clear which way the ultra-right community around Ukip wishes to go: their timelines are full of praise for Marine Le Pen and Geert Wilders , and blazing with imagery – both real and fake – of migrant riots in France and Sweden.
(5) Superman fans are up in arms at the decision of the publisher to appoint a noted anti-gay writer to pen the Man of Steel's latest adventures.
(6) By moving an electronic pen over a digitizing tablet, the subject could explore a line drawing stored in memory; on the display screen a portion of the drawing appeared to move behind a stationary aperture, in concert with the movement of the pen.
(7) Left ventricular cavity and muscle areas of each image were planimetered with a light-pen system and summated for volume: total volume = sigma (areas x 3 mm).
(8) The integrated sensing system is an ideal instrumental set up for viewing and recording the behaviour of rodents as well as other animals in the experimental pen throughout the year under varying weather and light conditions.
(9) The pullets were housed in battery brooder pens with raised wire floors.
(10) The dogs were housed in gravel-based, outdoor pens with doghouses in a high-altitude, high-sunshine level environment.
(11) There is a simple solution, formulated by English PEN, the Manifesto Club and the Earl of Clancarty, who raised the matter in the Lords earlier this year: remove short-term visits by non-EU artists from the PBS and expand the entertainer route, letting paid and unpaid artists qualify.
(12) In France last year, Marine Le Pen scored 18% in the presidential election and is now powering ahead against François Hollande, while in the Netherlands Geert Wilders' Freedom party is polling at 15%.
(13) With a stroke of his pen, he effectively declared the end of racism in America.
(14) The 27-year-old has put pen to paper on a three-and-a-half-year deal at the Emirates – he will wear the No23 shirt at the club – though confirmation that the deal had been ratified by the Premier League did not come until just before 5pm tonight.
(15) Harnessing its greatest asset – its authors – PEN is planning to publish an open letter to each of the five imprisoned writers every day this week, in the run up to the 33rd annual Day of the Imprisoned Writer on 15 November.
(16) An area on top of a hill near to the spot where Sharon was laid to rest alongside his late wife, Lily, was penned off with crash barriers.
(17) Deaths, 40 on CAZ and 21 on AG+PEN, were mainly related to their underlying condition.
(18) There is a god who protects me, and I just don’t believe Hofer will send me to a concentration camp.” Like Marine Le Pen’s Front National, the Freedom party has actively tried to distance itself from its antisemitic past since at least 2010, when it joined a cross-party alliance in the European parliament with Geert Wilders’ Party for Freedom and Italy’s Northern League.
(19) But Ukip is not the NF nor Trump, Nigel Farage is not Le Pen, father, daughter or niece Marion.
(20) I don’t think we should spend too long doing it.” Farage enjoyed support from the far-right French politician and Front National leader, Marine Le Pen , who spoke next.