(1) To study the role of the PENK gene in opioid related processes, an antisense sequence of PENK gene was subcloned into pSVL SV 40 late promoter expression vector and stably transfected into NG 108-15 cells, which contain opioid receptors.
(2) From steady-state kinetics half-life estimates of 9.6 h for PPenk mRNA and 14.7 h for Penk peptide were obtained.
(3) The Penk Combat Exposure scale did not separate the groups.
(4) "I was half expecting to see him on Songs of Praise," Penk added.
(5) Clinical observations and empirical evidence suggest that, among Vietnam combat veterans, Blacks are more maladjusted than Whites (e.g., Parsons, 1985; Penk et al., 1985).
(6) Penk, who now owns the Oldham-based local radio station 96.2 Revolution, said he was "appalled" at the "sheer scale of this unfair cross-promotion".
(7) "In these hard times it is difficult enough for the large, quasi-national commercial radio brands to compete with such unfair 'free' publicity," said Penk.
(8) The Penk Combat Intensity scale, which was correlated highly with the Keane scale, differentiated the PTSD-positive patients from both the normals and the PTSD-negative patients, but with less differentiating power (omega 2'S = .07 and .08).
(9) Facebook Twitter Pinterest The former Capital and Virgin Radio DJ Steve Penk has written to the BBC Trust to complain about the "excessive" and "gratuitous" cross-promotion of Chris Evans's new Radio 2 breakfast show on television.
(10) An increase in PENK mRNA levels has been also observed in cultures treated with 8-Br-cAMP, phorbol 12-myristate-13-acetate (TPA), or dexamethasone.
(11) Thus, activation of Penk gene expression upon neurotransmitter challenge is suggested to be due to an enhanced transcriptional activity of the gene mediated by de novo synthesized protein (-like) factors.
(12) We suggest that both the increased PENK message and the unchanged levels of free Met-enkephalin may be the result of compensatory mechanisms induced by translational inhibition by antisense, although the underlying processes remain to be determined.
(13) Penk was also critical of what he called the "placement" of Evans on BBC TV shows including Friday Night with Jonathan Ross, the One Show and the Andrew Marr Show.
(14) Unilateral adrenal denervation resulted in a rapid decrease in PPenk mRNA levels of 54% after 2 days, and by 11 days 90% of Penk mRNA had disappeared.
(15) Penk claimed the Evans trail broke the BBC Trust's own policy on cross-promotion.
(16) However, incubation of the cultures with the opioid agonist etorphine or the antagonist naltrexone did not alter PENK gene expression, suggesting that there is not feedback control of opioids on PENK biosynthesis in these cells.
(17) In this study we identified the potential sites of synthesis by localizing the mRNA coding for PENK in the rat pituitary gland using in situ hybridization histochemistry.
(18) Depolarization with potassium chloride (KCl) or veratridine increases the expression of PENK mRNA in a time-dependent fashion, with a maximal increase of sixfold.
(19) The proenkephalin A (PENK) gene codes for several opioid peptides, including Met-enkephalin, an endogenous ligand of opioid receptors.
(20) After an initial lag phase (with no major alterations) Penk mRNA increased markedly between 6 and 12 h followed by a slower, steady increase up to 48 h. The nicotinic receptor antagonist tubocurarine (4 x 10(-7) M) and the Ca2+ channel blocker D600 (10(-5) M) prevent the subsequent rise of Penk mRNA levels after challenge with nicotine, when given within the lag phase (0-6 h), suggesting the need of continuous receptor occupation and Ca2+ entry for induction of gene expression.
Pent
Definition:
() of Pen
(v. t.) Penned or shut up; confined; -- often with up.
Example Sentences:
(1) Some retailers said April's downpours led to pent-up demand which was unleashed at the first sign of summer, with shoppers rushing to update their summer wardrobes.
(2) The effects of the hypoglycaemic compound pent-4-enoic acid, and of four structurally related non-hypoglycaemic compounds (pent-2-enoic acid, pentanoic acid, cyclopropanecarboxylic acid and cyclobutanecarboxylic acid), on several reactions in rat liver mitochondria were determined.
(3) In a reconstituted sequence with purified enzymes crotonoyl-CoA was largely converted into acetyl-CoA, and pent-2-enoyl-CoA into acetyl-CoA and propionyl-CoA.
(4) Cell replication rates in male rats increased specifically in the histologically damaged P2 segments after PER or PENT exposure.
(5) The percentage inhibition of [1-(14)C]palmitate oxidation by pent-4-enoic acid was the same whether carnitine was present or not.
(6) The pent-up fury of the parents reflected the intensity of the violent protests that marked a dramatic week in Mexico, which has deepened the political crisis facing President Enrique Peña Nieto as he returns from a week-long trip to China and Australia, seen by many as a sign of disdain for the suffering and anger at home.
(7) Trichloroethylene (TCE), perchloroethylene (PER), and pentachloroethane (PENT) are widely used industrial chemicals that cause an increased incidence of hepatocellular carcinoma in mice and a very low incidence of renal tubular adenocarcinoma in rats.
(8) The metabolic effects of the hypoglycaemic agent pent-4-enoate were studied in isolated, beating or potassium-arrested rat hearts.
(9) Excitatory postsynaptic potentials (EPSPs) elicited by stimulation of mossy fibers were suppressed by Pent.
(10) N-(5-acetoxypent-1-yl)doxorubicin (4), which should give rise to N-(5-hydroxypent-1-yl)doxorubicin on esterase-mediated hydrolysis, and N-(pent-1-yl)doxorubicin (5), were also prepared for comparative biological studies.
(11) The return of Paragon was welcomed by mortgage broker Ray Boulger of John Charcol who said there was pent up demand for such lending from professional landlords, particularly since Lloyds Banking Group pulled back from the market this month.
(12) The mechanism of the hypoglycaemic effect of pent-4-enoic acid is discussed; it is suggested that there is an inhibition of fatty acid and ketone-body oxidation and of gluconeogenesis so that glucose reserves become exhausted, leading to hypoglycaemia.
(13) After exercise, the increase of [pent] was much smaller (240%) and was less significant (P less than 0.2) than with the placebo.
(14) But in a sign of pent-up reform pressure on Capitol Hill, two measures dealing with the NSA were quietly included in the 1,600-page spending text with relatively little fanfare – or opposition from the White House – and are likely to pave the way for more binding legislative efforts once President Barack Obama outlines his own response to the surveillance scandal on Friday.
(15) Renal alpha 2 mu concentrations in male rats increased after PER or PENT but not TCE administration.
(16) By partial hydrolysis, periodate oxidation, methylation, specific optical rotation, and 13C and 1H nuclear magnetic resonance studies, the structure of the O-chain was established as being a linear backbone of alternating 1,3-linked alpha-L-rhamnopyranosyl and beta-L-rhamnopyranosyl units, to which 2,2-linked beta-D-threo-pent-2-ulofuranoside (D-xylulofuranoside) units were present on every L-rhamnopyranosyl residue, as shown below.
(17) Pent-4-enoate (0.1mm) caused a rapid and almost complete decrease in free CoA and a large increase in acid-soluble acyl-CoA when incubated with coupled mitochondria.
(18) With transactions at two-thirds of their 2007 peak, prices are finally reacting as much to pent-up demand as to the prospect of economic growth.
(19) Under these conditions 1-(2,3-dideoxy-5-O-p-toluyl-alpha-D- glycero-pent-2-enofuranosyl)-5-Tms-uracil was obtained from 1-(2-deoxy-alpha-D-ribofuranosyl)-5-Tms-uracil.
(20) Lipopolysaccharides of Yersinia enterocolitica serovars O:5 and O:5,27 were shown to have a similar sugar composition, consisting of L-rhamnose, D-glucose, D-galactose, D- and L-glycero-D-manno-heptose, 2-acetamido-2-deoxy-D-glucose, 2-acetamido-2-deoxy-D-galactose, 3-deoxy-D-manno-octulosonate and D-threo-pent-2-ulose (D-xylulose).