(a.) Divided into, or consisting of, five parts; also, arranged in sets, with five parts in each set, as a flower with five sepals, five petals, five, or twice five, stamens, and five pistils.
(a.) Belonging to the Pentamera.
Example Sentences:
(1) Pentameric extracellular IgM and monomeric membrane IgM were diminished by HuIFN-alpha(ly) treatment, respectively, in ST8246 cells and in Daudi cells.
(2) We have studied the ability of E-SCon A (ES) to interact with early acting guinea pig (gp) or human (hu) complement components (C1, C2, C4) and found that cell intermediates ESC1, ESC4, ESC14, and ESC142 can be generated that are analogous to intermediates conventionally prepared with E and rabbit IgM (pentameric) anti-Forssman antibody.
(3) Iodoacetic acid and N-ethylmalemide were found to be effective in disrupting the pentameric form of phospholamban only when reacted with sodium dodecyl sulfate solubilized sarcoplasmic reticulum.
(4) Gel filtration of pairs of PS and LS from four individuals revealed IgM, IgA, and IgG to elute in positions commensurate with pentameric IgM, secretory IgA, and monomeric IgG.
(5) These proteins were produced in large amounts and released into the culture supernatant as monomeric and pentameric molecules.
(6) Based on this conformity the molecular structure of rat FP was analyzed and as the results a pentameric structure could be demonstrated for rat FP, too.
(7) The inhibitory glycine receptor (GlyR) is a pentameric chloride channel protein which mediates postsynaptic inhibition in the mammalian central nervous system.
(8) The orientation of the pentameric molecule is shown to be almost identical in both forms, about the axial direction omega = 57 degrees, phi = 45 degrees, i.e.
(9) On isoelectrofocusing, MP1 pentameric IgM gave a restricted banding pattern comparable to monoclonal IgM obtained from a patient with Waldenström's syndrome.
(10) The nicotinic acetylcholine receptors (AChRs) of the skeletal muscle consist of pentameric ion channels, each of which is composed of 4 kinds of subunits.
(11) To understand the nature of the discrepancy with human IgG, 5 Hu-MAbs of the 3 classes (2 IgG, 2 pentameric IgM and 1 IgA) were purified to homogeneity for a more detailed analysis.
(12) Pentameric IgM is likewise actively enriched in most exocrine fluids and is associated with SC, although not in a covalently stabilized complex.
(13) The molecular weight falls to 67,300 after treatment with disulfide reducing agents, thus supporting the concept of a pentameric structure for IgM.
(14) However, no conclusions can be made from this study regarding the structure of pentameric IgA, since this species was present in very small amounts in our polymer preparation.
(15) (1) One class included two sets of repeating pentameric DNA sequences, d(CCAAT)3-6 and d(AATCC)4,5.
(16) These results indicate that F(c)5 mu may have more Fc regions exposed per molecule for binding to the matrix of RFcmu than pentameric IgM and that Fc multivalency may be important for the stable binding of IgM to RFcmu.
(17) Wild-type IgM, while synthesized predominantly as a pentameric molecule, was assembled in at least two other forms, which were distinguished by their electrophoretic mobility.
(18) The (Sso L12e)4-Sso L10 pentameric complex, identified previously from studies in solution, appears to represent correctly the arrangement of these proteins in the ribosome.
(19) Monomeric IgM and IgM bound to its antigen blocked much more effectively than pentameric IgM.
(20) The successful expression of this pentameric protein complex combining transfection and infection techniques demonstrates one strategy for stably introducing the genes of a heterologous multisubunit protein complex into cells.
Trimerous
Definition:
(a.) Having the parts in threes.
Example Sentences:
(1) Although lipopolysaccharides seem to play a significant role in the final assembly of the trimeric porins, the details of the targeting process still remain to be elucidated.
(2) The observed predominance of trimeric over dimeric oligomers even at short times suggests that the thrombin-catalyzed release of the two A fibrinopeptides from a single molecule of fibrinogen is highly cooperative.
(3) Thrombospondin (TSP), a 450-kDa trimeric glycoprotein secreted by platelets and endothelial cells at sites of tissue injury or inflammation, may play an important role in polymorphonuclear leukocyte (PMN) adherence to blood vessel walls before diapedesis.
(4) Porin is a trimeric channel-forming protein in the outer membrane of Gram-negative bacteria.
(5) End-on views of G on virus clearly showed triangles consisting of three dots indicating the trimeric nature of native G. End-on views of CHAPS-isolated G showed very similar triangles confirming that, using this detergent, G was solubilized in its native trimeric structure.
(6) Under optimum conditions, 2-5A trimer and other 2-5A derivatives inhibited over 90% of HSV-1 syncytia formation and over 50% of HSV-2 plaque formation.
(7) They appear to be a dimer, trimer and tetramer in which tyrosine units are linked by biphenyl bonds.
(8) The trimers are found to be in slow equilibrium with hexamers and higher oligomers composed of multiples of three copies of the CAD polypeptide chain.
(9) A comparison study of nmr and cd spectra of quadrigemine C and hodgkinsine [3], a trimeric pyrrolidinoindoline substance, led us to suggest the stereochemistry of quadrigemine C. The structure and configuration of psycholeine was determined by spectroscopic means and chemical correlation with quadrigemine C. Psycholeine interacts with somatostatin receptors and exhibits a somatostatin antagonistic activity on GH secretion by pituitary cells in primary culture.
(10) AP-2 bound to these "clipped cages"; however, unlike the interaction with native cages, binding of AP-2 to clipped cages was sensitive to the lower concentrations of both Tris-HCl and NaPPPi which disrupt interactions of AP-2 with clathrin trimers.
(11) The distribution among the four species as a function of ligand concentration in the absence of succinate indicates that in the native oligomer, pyridoxal phosphate (and by extrapolation, carbamyl phosphate) binds to both catalytic trimers, rather than to three sites on a single subunit.
(12) Insertion of the trimer into several expression vectors efficiently prevented spurious expression of reporter genes resulting from transcriptional initiation in prokaryotic plasmid sequences in transfected mammalian cells.
(13) The order of inhibition was polymer greater than oligomer greater than trimer greater than dimer.
(14) Protein aggregation is dependent on the concentration of background electrolyte since in the range 10-150 mM sodium cacodylate alternative stabilisation of dimeric and trimeric complexes was observed by both NMR and analytical ultracentrifugation.
(15) In immunoblots all monoclonal antibodies, except one, recognized only the trimeric, but not the monomeric form of VP6.
(16) Like pJFCAT1, pTAG-1 also includes the simian virus 40 polyadenylation site trimer cassette located just upstream of the promoter insertion site.
(17) Electron image analysis revealed that the crystals are composed of trimers of annexin-V forming triskelion-like motifs.
(18) Aminomalononitrile (HCN trimer) reacts with electrophiles such as aldehydes and acrylonitrile under very mild conditions of temperature and pH to produce intermediates which, after acid hydrolysis, yield amino acids.
(19) Third, trimerization occurs only after the HA has been transported from the endoplasmic reticulum.
(20) We found no consistent difference in the melting curve of the alpha 1(I) trimers compared to control type I collagen.