(a.) Last but one; as, the penultimate syllable, the last syllable but one of a word.
(n.) The penult.
Example Sentences:
(1) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(2) In tripeptides with a neutral amino acid in the penultimate position, amidation, took place readily but the reaction was slower when this position was occupied by an acidic or a basic residue.
(3) 7.21pm GMT The normal hill world champion, Anders Bardal of Norway, is the penultimate man off the normal hill.
(4) A metabolite of nabilone in feces has been identified as a diol formed by reduction of the 9-keto group plus oxidation at the penultimate carbon of the dimethylheptyl side chain.
(5) Thus, a greater than 1300-fold range in apparent inhibitor constants was observed by substitution at the -1 (penultimate) position in a C-terminal glycine-containing tripeptide with each of the 20 common L-amino acids.
(6) "I'm Ms Dy-na-mi-TEE-ee," she sang on the chorus, putting an emphasis on the penultimate syllable.
(7) In this study, to achieve a systematic analysis of the specificity of MAP action, each of the 20 amino acids was introduced at the penultimate position of methionyl-tRNA synthetase of E. coli and the extent of in vivo methionine excision was measured.
(8) The birth interval between the index and penultimate child was 2 years or less in 20% and 2-3 years in 40%.
(9) The fast-twitch Ca2+ ATPase transcript undergoes developmentally regulated alternative splicing in which a penultimate 42-base pair exon is retained in the adult transcript but is excised in the neonatal transcript.
(10) 60% that of the yeast iso-1-cytochrome c. N-terminal processing of indigenous rat cytochrome c, in which the N-terminal methionine residue is cleaved and the penultimate glycine residue is acetylated, also occurred in yeast.
(11) These data indicate that the penultimate amino acid for the primary cleavage site of factor X by CP is proline-20 and for the secondary sites, proline-13 and proline-28.
(12) Placing a ribonucleotide at the penultimate position coupled by a phosphorothioate linkage to a terminal 2',3'-dideoxynucleotide reduced the rate of exonucleolytic activity almost 30,000-fold (half-life approximately 16 h).
(13) Oxidation of dihydrostreptomycin 6-phosphate to streptomycin 6-phosphate very probably represents the penultimate step in the biosynthesis of streptomycin.
(14) Charlotte Eagles gave Chivas USA an almighty scare, by equalizing in the penultimate minute of regulation time, through Mauricio Salles, only for Jose Correa to break their hearts deep into stoppage time.
(15) Subsequent removal of penultimate galactose residues returned both antibody survival time in the circulation and organ distribution to near normal.
(16) This hypothesis predicts that tumor cells of the ultimate stage will carry each of the events; cells of the penultimate stage will carry each of the events minus the last one; and so on.
(17) The data imply that sensitivity to the 2',5'-phosphodiesterase activity of mouse L cells requires the presence of 3'-hydroxyl moiety in the penultimate nucleotide.
(18) It could have been his team celebrating a Double had they won at Villa Park and avoided defeat in their penultimate league game of the season to Leeds United, a match in which events seemed to conspire against them as dramatically as they went in favour of Ferguson’s side.
(19) Instead it is an exopeptidase with a high specificity for NH2-terminal-free peptides containing a proline residue in the penultimate position and releases the dipeptide with proline being the COOH-terminal moiety.
(20) On the other hand, the maximum OERs for two GSH- mutants, 7 and 821, both deficient in gamma-glutamylcysteine synthetase, the penultimate enzyme in the GSH biosynthetic pathway, were about 2.7 and the K-values were about 0.06% O2 for both.
Ultimate
Definition:
(a.) Farthest; most remote in space or time; extreme; last; final.
(a.) Last in a train of progression or consequences; tended toward by all that precedes; arrived at, as the last result; final.
(a.) Incapable of further analysis; incapable of further division or separation; constituent; elemental; as, an ultimate constituent of matter.
(v. t. & i.) To come or bring to an end; to eventuate; to end.
(v. t. & i.) To come or bring into use or practice.
Example Sentences:
(1) Even former Florida governor Jeb Bush, one of Trump’s chief critics, said ultimately, “anybody is better than Hillary Clinton”.
(2) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
(3) The mechanism by which gp55 causes increased erythroblastosis and ultimately leukaemia is unknown, but a reasonable suggestion is that gp55 can mimic the action of erythropoietin by binding to its receptor (Epo-R), thereby triggering prolonged proliferation of erythroid cells.
(4) It is found that, whereas the spatial resolution achievable with such a system is only dependent upon its temporal resolution, the scattering characteristics of the tissue being imaged will strongly affect the ultimate imaging performance of such a system.
(5) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(6) The citizenship debate is tawdry, conflated and ultimately pointless | Richard Ackland Read more On Wednesday, the prime minister criticised lawyers for backing terrorists.
(7) Hydroperoxides from arachidonic acid can decompose via this mechanism to form leukotrienes of potential biological significance and can catalyze the epoxidation of proximal carcinogens to ultimate carcinogenic metabolites.
(8) Ultimate nonsurvivors of ICU admission (36 per cent) had shorter out-of-hospital times, shorter travel distances, and increased interventional support, as assessed by the Therapeutic Intervention Scoring System applied over the telephone and prior to departure at the referring hospital.
(9) Ultimately, prevention is a better approach than cure.
(10) Twenty-three cases were reviewed with an ultimate amputation rate of 61% (22% primary, 39% delayed).
(11) Ultimately, both Geffen and Browne turned out to be correct: establishing the pattern for Zevon's career, the albums sold modestly but the critics loved them.
(12) Differential degeneration of the lateral microvessels may account for increases in collagen nodule growth and ultimate size.
(13) The sensitivity of a PCR system to amplify the long terminal repeat (LTR) sequence of HIV-1 was not affected by the irradiation procedure; however, the ultimate sensitivity of a PCR system for the amplification of an early gene promotor sequence of the CMV genome was reduced 1000-fold.
(14) Both sides sought a decisive goal in a frenetic finish but ultimately the league leaders and the side fighting relegation shared the points and Mourinho wound up making dark allusions to the influence of officials .
(15) The ultimate mutagenic form(s) are therefore unlikely to be acetoxyarylamines.
(16) The finding confirms that procarcinogenic dialkyl aryltriazenes must be enzymatically converted into reactive metabolites, presumably into the corresponding monoalkyltriazenes, which ultimately react with tRNA.
(17) Do get yourself elected as a governor If you’re lucky, your school hasn’t yet been swallowed up by a private academy chain, and so its governing body still has ultimate power, and the headteacher is accountable to it.
(18) A 73-year-old woman who presented with primary adrenal insufficiency and enlarged adrenal glands on computed tomographic scanning was ultimately found to have a large-cell lymphoma that had initially involved the adrenals and the stomach.
(19) Psychiatric testimony to ultimate questions at law is limited by the inherent contextual variables of psychiatric clinical and experimental knowledge and practice.
(20) Ultimately, the judgments combine to make a particularly peculiar melange: among the plaintiffs there is a mix of economic pessimism and insecure nationalism with a shot of nostalgia for the Deutschmark.