(1) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
(2) Ultraviolet difference spectrophotometry indicates that the inactivated enzyme retains its capacity for binding the nucleotide substrates whereas the spectral perturbation characteristic of 3-phosphoglycerate binding is abolished in the modified enzyme.
(3) It is suggested that laboratory experiments should be performed on perturbed systems only if simulations have shown that the methods of data analysis will be satisfactorily powerful and accurate.
(4) Thresholds were measured for detecting perturbations in a regular lattice of dots by modulating local dot density, local dot luminance, or some combination of the two.
(5) It is shown that when a constant current is applied such that a stable equilibrium and rhythmic firing are present, the following predictions are inherent in the HH system of equations: (a) Small instantaneous voltage perturbations to the axon given at points along its firing spike result in phase resetting curves (when new phase versus old phase is plotted) with an average slope of 1.
(6) Lower lip perturbation duration was manipulated to yield two different load conditions.
(7) The role of the Golgi complex in the post-translational oligosaccharide maturation of alpha-amylase was explored by use of the carboxylic ionophore, monensin (10(-7)M), a known perturbant of the structure and function of the Golgi complex.
(8) The importance of the ionic interaction due to the formation of the salt bridge between the Asp-27 and the pteridine ring in Escherichia coli dihydrofolate reductase-methotrexate complex has been studied by using the free-energy perturbation method.
(9) Presence of the monosynaptic reflex during platform perturbations at normal latencies suggests that balance problems in children with Down syndrome do not result from hypotonia, which researchers have defined as decreased segmental motoneuron pool excitability and pathology of stretch reflex mechanisms, but rather result from defects within higher level postural mechanisms.
(10) We have perturbed the dynamics of the nuclear lamins by means of cell fusion between mitotic and interphase cells and have studied redistribution of lamins in fused cells as a function of extracellular pH levels.
(11) In the coagulating gland, this compensatory response involved the proliferation of many cells which, in the absence of cytotoxic perturbation, would be non-proliferatie (Q cells).
(12) The effect of initial perturbation of the thrombus by a guide wire appears to be less important than the thrombus disruption and accelerated thrombolysis caused by the pulsatile delivery system.
(13) As before, subjects were instructed to either oppose the perturbation (Predictable Oppose) or relax the forearm muscles (Predictable Let-Go).
(14) Bivalent cations (Ca2+, UO2(2+) or Zn2+) in the subphase at pH 5.6 significantly modified the behaviour of mixed monolayers of fusogenic lipids with phospholipids; there was a parallel perturbing effect of fusogenic lipids on interactions between monolayers of phospholipids and bivalent cations.
(15) In particular, nitration of Tyr-51 provoked a structural perturbation in the globular region.
(16) Altering the biophysical characteristics of cell membranes by diet and membrane perturbing agents markedly influences thermosensitivity of cells.
(17) Paraphilias (PAs) and non-paraphilic sexual addictions (NPSAs) may be behaviors that share a common perturbation of central serotonin neuroregulation as a component of their pathophysiology.
(18) Two functions of these have been proposed: 1) that they are compatible osmolytes which regulate cell volume (against high external NaCl) without inhibiting proteins and 2) that methylamines (GPC and betaine) are counteracting osmolytes which stabilize proteins against perturbation from high renal urea.
(19) This high incidence of HER2 gene amplification with accompanying overexpression in non-invasive breast tumors suggests that perturbations of the HER2 oncogene are among the earliest and most common genetic lesions in human breast cancer.
(20) Hypophysectomy was selected as a model system for perturbing testicular cell types, since the cytological sequelae of this treatment post-hypophysectomy in the rat are well documented in the literature.
Uneasy
Definition:
(a.) Not easy; difficult.
(a.) Restless; disturbed by pain, anxiety, or the like; disquieted; perturbed.
(a.) Not easy in manner; constrained; stiff; awkward; not graceful; as, an uneasy deportment.
(a.) Occasioning want of ease; constraining; cramping; disagreeable; unpleasing.
Example Sentences:
(1) Some journalists are uneasy at this notion of keeping an audit trail of thinking, authority and pre-publication decision-making?
(2) I appreciate things like that.” News about things like overreach in government surveillance make her uneasy but she said her tendency would be to shrug and say: “As long as I have no plans to threaten the national security, I don’t really have any reason to worry.” “In term of health privacy though, once we start thinking about health and our families, I think it’s very easy to realize that this is the most sensitive personal information about us,” she said.
(3) Sometimes the public’s legitimate fears are exposed: in Colombia there’s no doubt the public felt uneasy about forgiving Farc for its bloody violence.
(4) William’s trip will put a spotlight on his father’s uneasy relationship with China and raise questions about why Charles has yet to make an official visit to the country.
(5) In short, Bamako remains uneasy, and the "sacred union" of the last few days can only be temporary.
(6) As MPs return from their summer holidays, Conservative rebellions are looming over rising rail fares, rising fuel duty and, as we report today, Tory councillors are growing increasingly uneasy over planned cuts in council tax relief which they say will hit low earners disproportionately hard in April.
(7) People wander this disconcerting garden a long time, uneasy and reflective.
(8) With a few striking exceptions, such as William Dalrymple and Philip Hensher , contemporary writers have become wary of engaging with it in all its complicated, uneasy-making richness.
(9) At the same time, approximately one-third were aware of reporting issues that needed to be addressed, including staff unfamiliarity with the regulations, concerns of confidentiality, and uneasiness about reporting in general.
(10) But Cameron said he felt uneasy that in the film Assange appears to be more concerned about the fate of people who leaked documents to WikiLeaks – an apparent reference to Chelsea Manning – rather than people whose security may have been jeopardised by the leaks.
(11) Sorry, I mean it would be the department of trade.” She gives a shrill, uneasy laugh.
(12) It is by no means a total success artistically but it has enough tension, feeling and originality of theme and speech to make the choice understandable, and the evening must have given to anyone who has wrestled with the mechanics of play-making an uneasy and yet not wasted jaunt, just as it must have awoken echoes in anyone one who has not forgotten the frustrations of youth.
(13) We are still in the midst of the uneasy period of phoney war before the cuts actually bite, but we now know what's coming: the deepest and quickest reductions in public spending since the 1920s – which, according to an under-reported quote from David Cameron , will not be reversed, even when our economic circumstances improve (2 August, at an event in Birmingham: "Should we cut things now and go back later and try and restore them later?
(14) This was an evident need since up to now each school applied a different criterion to qualify its graduates; the resulting disparity in the scores with which graduates applied for the National calls in postgraduate training programs, general practice positions and the like, elicited uneasiness both among graduates and academic staff.
(15) We insist upon the priority of the relationship doctor-patient in the case of a chronicle affection, which is less uneasy for some and shameful for a great many.
(16) Turkish police appeared uneasy at the size of the crowd gathered near a fragile border fence and fired teargas grenades to disperse them, adding the crack of smaller explosions to the rumbling of the Isis advance.
(17) Key party members stressed they had no master plan in response to the vote, but said it could not be ignored and argued many Conservatives were uneasy about the reforms.
(18) Browne said he was "instinctively uneasy" about restricting religious freedoms, but he added there may be a case to act to protect girls who were too young to decide for themselves whether they wished to wear the veil or not.
(19) If you genuinely do distrust industrial production, if you do believe that a mass, mechanised civilisation is incompatible in some way with democracy, post-fossil fuel economy or a humane society in general – and such opinions are not rare – then you necessarily have to own up to the critique, something that the guiltily uneasy combination of hay bales and laptops found at many protest camps can make especially uncomfortable.
(20) In certain telling ways the response of the nation’s leaders to the recent market crash is emblematic of a much larger dilemma – one that sits right at the heart of China’s uneasy fusion of communism and free-market economics, a system with little precedent and no operating manual.