(n.) An instrument or device to be introduced into and worn in the vagina, to support the uterus, or remedy a malposition.
(n.) A medicinal substance in the form of a bolus or mass, designed for introduction into the vagina; a vaginal suppository.
Example Sentences:
(1) The substance benzalconium chloride (BZC) was contained in vaginal sponges (n = 46), pessaries (n = 4) and cream (n = 6) at a dose rate of 1.18%.
(2) Gemeprost 1 mg vaginal pessaries were inserted at 3 hr intervals for a maximum of 5 doses.
(3) It is concluded that PGE2 vaginal tablets--a chemically stable alternative to pharmacy prepared pessaries--appear to be effective as regards cervical ripening as well as for labor induction.
(4) Each ewe was inseminated in the uterus with fresh semen 24 h after pessary withdrawal.
(5) All 50 women who received gemeprost vaginal pessaries every 3 hours aborted within 48 hours, while 10% who received them every 6 hours did not abort.
(6) Of the potentially useful compounds, only derivatives of prostaglandins E and F administered by vaginal pessary have so far been shown to be effective.
(7) A single course of 4 x 1 mg gemeprost pessaries was administered every six hours.
(8) This double-blind study is concerned with the efficacy and safety of a new prostaglandin E1-analogue (16,16'-dimethyl-trans-delta 2PGE1-methylester) (Gemeprost) (ONO-802), which was administered as a single 1 mg vaginal pessary three hours prior to legal abortion.
(9) Both groups showed a rise in plasma PGE2 levels in keeping with the release profiles of the pessaries.
(10) Moreover, women who received RU-486 required significantly fewer gemeprost pessaries (median of 3) than controls (median of 5); the former women also required significantly less analgesia.
(11) In a randomized, double-blind clinical trial from general practice, 500 mg metronidazole pessaries applied once daily for seven days were compared with placebo in the treatment of bacterial vaginosis.
(12) These results suggest that in many women the number of pessaries used to induce mid-trimester abortion could be reduced by lengthening the interval between insertion of pessaries within the first 24 h, without loss of clinical efficacy.
(13) A questionnaire study was carried out to investigate the needs of women undergoing a medical abortion induced by mifepristone in combination with either gemeprost pessaries or oral misoprostol.
(14) This correction is made either by putting a pessary, either by a surgical cure unless the risk should be too important for the patient.
(15) The mean (SD) induction-abortion interval (IAI) in the vaginal pessary group of 19.5 (8.4) h was significantly longer than the respective intervals of 14.4 (9.3) and 16.1 (6.8) h in the patients treated extra- or intra-amniotically (P less than 0.001).
(16) In order to define the patterns of TSH, T4, T3, rT3, GH and cortisol during the estrous cycle of sheep, pluriparous and primiparous ewes were synchronized with progestagen-impregnated pessaries (Veramix) at the start of the normal breeding season.
(17) In a prospective randomized trial of 106 patients who had spontaneously ruptured their membranes greater than or equal to 4 hours in the absence of labour, vaginal prostaglandin E2 pessaries and intravenous Syntocinon were compared.
(18) One hundred fourteen women received a placebo pessary and 101 received the hydrogel pessary, containing 10 mg of prostaglandin (PG) E2.
(19) Though isoconazole was formulated for single dose usage, econazole was formulated for a regimen of one pessary a night for three nights.
(20) After insertion of the pessary, 44 women received an oral analgesic drug and 9 an intramuscular opioid.
Suppository
Definition:
(n.) A pill or bolus for introduction into the rectum; esp., a cylinder or cone of medicated cacao butter.
Example Sentences:
(1) Diclofenac sodium suppositories 150-200 mg day-1 were compared with placebo in a double-blind study during the first 3 days after uvulopalatopharyngoplasty in 40 patients with habitual snoring or obstructive sleep apnoea syndrome.
(2) The in vitro and in vivo results show that the release of indomethacin from fatty-base suppositories stored at a high temperature is less than the release from those stored at a low temperature.
(3) After liberation of 5-ASA in the terminal ileum (only slow release oral preparations of 5-ASA) and colon (5-ASA suppositories and enemas), 5-ASA is only partly absorbed.
(4) Rectal suppository is a well-known form of medication and its use is increasing.
(5) The administration of PGE2 vaginal suppositories offers an effective and safe technique for the induction of labor in patients with IUFD.
(6) The absorption times of the two drugs from suppositories with cocoa butter and Witepsol H 15 were relatively short.
(7) In vitro release of benzocaine from some commercially available suppositories was compared with experimental preparations.
(8) The adsorption in humans of nitrofurantoin from seven suppository bases was studied using urinary excretion measurements.
(9) The results show that both hydrocortisone (H) and prednisolone-21-hexanoate (P) are rapidly (tmax = 2-3 h) and significantly (H: 60-78%, P: 47-58%) absorbed from suppositories and thus can also cause systemic effects.
(10) Three cases of adenocarcinoma of the lower esophagus and cardia which is considered to be difficult to control by radiotherapy alone, were given radical irradiation combined with FT-207 suppository.
(11) In volunteers the activity of various doses of a nasal spray and of a suppository of salmon calcitonin was compared to a placebo and to the parenteral route of administration.
(12) When vomiting occurs early in the attack, treatment is best given by suppository, inhalation or intramuscular injection.
(13) Primary eye irritation of MCG suppository of CMZ was studied in rabbits.
(14) Treatment consisted of daily intravaginal application of one of the following regimens: 80-mg terconazole suppositories for 3 days, miconazole nitrate suppositories for 7 days or placebo suppositories for 7 days.
(15) Further studies in pregnant women showed that PGE2 administered in special vaginal suppositories resulted in: 1) 1 case at the 23rd week of pregnancy, the expulsion of the dead fetus by inserting 2 suppositories (4 mg PGE2 each) with the induction delivery time of 2 hours 20 minutes, and 2) one case in which the expulsion occurred after 1 suppository with an induction delivery time of 4 hours 30 minutes.
(16) We were enlightened by this therapeutic experience, so we attempted combination therapy using pepleomycin suppositories to supplement intra-cavitary irradiation, for the 11 selected patients who were suffering from uterine fluor.
(17) Oral administration gave higher values for mean residence time (MRT) and absolute bioavailability (F) compared to suppository dosage forms.
(18) 1 group (non-diaphragm) had a 20 mg. suppository inserted every 4 hours high in the vaginal fornix.
(19) Patients were divided into three treatment groups: one group received the drug intravenously, another as suppositories and the third one by both routes.
(20) The women were all 9 weeks pregnant, and received 600 mg RU-38486 orally at 10.30 hr, followed 48 hours later by a vaginal suppository containing 1 mg 16,16- dimethyl-trans-2-PGE1 (Gemeprost, May and Baker).