What's the difference between phencyclidine and tic?
Phencyclidine
Definition:
Example Sentences:
(1) To test the hypothesis that EAA agonists are involved in transmission of nociceptive information in the spinal cord, we tested the effect of various opioid, sigma and phencyclidine compounds on the action of NMDA in the tail-flick, hot-plate and biting and scratching nociceptive tests.
(2) The increase probably reflects an inhibition of the re-uptake of released 3H-noradrenaline; in addition, phencyclidine appears to enhance the release of noradrenaline per pulse.--The actions of phencyclidine and ketamine on central noradrenergic neurones may contribute to the characteristic psychotropic side-effects of these general anaesthetics.
(3) The present experiments compared the noncompetitive N-methyl-D-aspartate antagonists phencyclidine and MK-801 with the anticonvulsant phenytoin in a model of focal brain ischemia.
(4) The neuronal localization of glutamate and phencyclidine (PCP) receptors was evaluated in the cerebral cortex and hippocampal formation of rat CNS using quantitative autoradiography.
(5) Emergency Room patients at Riverside General Hospital who are found by the attending physician to have depressed sensorium and altered personality are routinely subjected to urine tests for various drugs of abuse including phencyclidine (PCP).
(6) Phencyclidine (PCP) is a dissociative anesthetic agent which blocks the excitatory effect of N-methyl-D-aspartate (NMDA) in the central nervous system.
(7) Only the sigma agonist, phencyclidine, showed any capacity for blocking the PTZ stimulus.
(8) Drugs of the fentanyl series (4-anilino-piperidines) were potent displacers whereas agonists of the delta- (enkephalin derivatives), sigma- (phencyclidine, haloperidol, 3-hydroxyphenyl-propylpiperidine) or K- (U 50488) opiate sites had a low affinity (Ki greater than 0.5 microM) for 3H-lofentanil specific binding sites.
(9) Related compounds including [D-Ala2, D-Leu5]enkephalin (DADLE), n-allylnormetazocine and phencyclidine were also examined.
(10) Phencyclidine residues were found in the brains of rat pups of mothers dosed with this drug during pregnancy.
(11) For 15 unselected urines the concentrations of phencyclidine showed no significant correlation with urinary pH.
(12) However, at high doses, DTG selectively suppressed the potentiation induced by a low dose of DTG and reduced the NMDA response below base line, presumably due to its low affinity for phencyclidine sites.
(13) Phencyclidine, which is an indirect dopaminergic agonist in the caudate, caused inhibition of the discharges of caudate neurons resembling that induced by dopamine itself.
(14) Significantly more blunting of the response of TSH to TRH was shown in cocaine and phencyclidine abusers compared with that seen in controls.
(15) Recently, we reported the characterization of a selective sigma receptor ligand, 1,3-di-o-tolyl-guanidine (DTG), that shows negligible crossreactivity with phencyclidine receptors.
(16) Phencyclidine had a biphasic effect on overall response rates in both components: response rates increased and then decreased as the dose was increased.
(17) The effects of phencyclidine infusions on fixed-ratio responding were variable.
(18) One of the analogs, cis-2-hydroxymethyl-r-1-(N-piperidyl)-1-(2-thienyl) cyclohexane (5) was found to show a high affinity (IC50 = 16 nM) for the phencyclidine (PCP) binding sites, very close to that of TCP, and to be 38-fold more potent in binding than its trans isomer.
(19) In animals sedated with phencyclidine or ketamine the only significant difference detected was in the mean cell volume.
(20) [3H]N-1-(2-Thienyl)cyclohexyl-3,4-piperidine binding to the phencyclidine site associated with the N-methyl-D-aspartate receptor was reduced by 60-80% in all brain regions examined (P less than 0.001).
Tic
Definition:
(n.) A local and habitual convulsive motion of certain muscles; especially, such a motion of some of the muscles of the face; twitching; velication; -- called also spasmodic tic.
Example Sentences:
(1) A case of epidermoid tumor presenting with a painful tic convulsif was reported.
(2) This treatment was given to 11 patients with Huntington's chorea (ChH), 4 with faciolingual dyskinesis (DFL), 3 with torticollis spasmodicus (TS), 3 with maladie des tics (MT) and 8 with dyskinesia following treatment with L-dopa (MP).
(3) The highest predictive values for the exclusion of TiC are shown by inconspicuous concentration capacity accompanied by normal ammonia excretion, total acid excretion, water diuresis, free water clearance or urine dilution capacity.
(4) In an effort to test this hypothesis, the relationships between organism concentrations and water chemistry parameters that have the potential to alter Cd availability including pH, calcium (Ca), total organic carbon (TOC) and total inorganic carbon (TIC) were examined.
(5) Tics are modified by multiple psychological contents (aggressive or sexual impulses, imitation of others) which tend to become independent of their origin.
(6) On the basis of the achieved results the author comes to the conclusion that in the pathogenesis of a pseudoneurotic tic an important role is being played by a premorbid insufficiency of the motor analyzer.
(7) The authors hypothesize that neurotransmitter abnormalities existing in Down's syndrome may predispose such individuals to basal ganglia dysfunction and the subsequent development of tics.
(8) All tics subsided before the age of 20 years, only to recur after the age of 60 years, once again including both motor and vocal tics that changed in location and severity slowly over time.
(9) The observation of a young north african afflicted with a tic disorder suggests an underlying meaning in the apparently confused motoric discharges, thanks to psychodrama and to ethnopsychoanalytic consultations with the family.
(10) Only PIP or TIC + SUL or TAZ were able to inhibit at least 90% of tested strains.
(11) Five of our 7 patients had a positive family history of tics, and 2 a confirmed family history of gout.
(12) When diagnostic criteria were broadened to include any tics in co-twins, concordance rates were 77% and 23% for MZ and DZ pairs, respectively.
(13) Associated psychopathology was common: 38% received an anxiety disorder diagnosis; 29% received a mood disorder diagnosis; tics were observed in 24%.
(14) Pharmacological intervention, using clonidine, also did not reduce tic frequency.
(15) Further there are associations between a family history of tics and obsessive compulsive disorder in the subsequent generation.
(16) The narrative drivers are pretty slack – improbable dialogue ("I'm a very wealthy man, Miss Steele, and I have expensive and absorbing hobbies"); lame characterisation; irritating tics (a constant war between Steele's "subconscious", which is always fainting or putting on half-moon glasses, and her "inner goddess", who is forever pouting and stamping); and an internal monologue that goes like this … "Holy hell, he's hot!
(17) The activity of TIC against Bacteroides fragilis was improved up to 64-fold by clavulanic acid, with a definite but less pronounced effect on the non-fragilis Bacteroides species.
(18) The tic occurred 40 to 50 times per minute on its peak at age 16.
(19) In a direct interview study, the perinatal experiences of 31 TS patients were compiled in an effort to identify risk factors associated with tic severity.
(20) The majority of patients with tic douloureux are successfully treated by pharmacotherapy with phenytoin or carbamazepine.