(1) To test the hypothesis that EAA agonists are involved in transmission of nociceptive information in the spinal cord, we tested the effect of various opioid, sigma and phencyclidine compounds on the action of NMDA in the tail-flick, hot-plate and biting and scratching nociceptive tests.
(2) The increase probably reflects an inhibition of the re-uptake of released 3H-noradrenaline; in addition, phencyclidine appears to enhance the release of noradrenaline per pulse.--The actions of phencyclidine and ketamine on central noradrenergic neurones may contribute to the characteristic psychotropic side-effects of these general anaesthetics.
(3) The present experiments compared the noncompetitive N-methyl-D-aspartate antagonists phencyclidine and MK-801 with the anticonvulsant phenytoin in a model of focal brain ischemia.
(4) The neuronal localization of glutamate and phencyclidine (PCP) receptors was evaluated in the cerebral cortex and hippocampal formation of rat CNS using quantitative autoradiography.
(5) Emergency Room patients at Riverside General Hospital who are found by the attending physician to have depressed sensorium and altered personality are routinely subjected to urine tests for various drugs of abuse including phencyclidine (PCP).
(6) Phencyclidine (PCP) is a dissociative anesthetic agent which blocks the excitatory effect of N-methyl-D-aspartate (NMDA) in the central nervous system.
(7) Only the sigma agonist, phencyclidine, showed any capacity for blocking the PTZ stimulus.
(8) Drugs of the fentanyl series (4-anilino-piperidines) were potent displacers whereas agonists of the delta- (enkephalin derivatives), sigma- (phencyclidine, haloperidol, 3-hydroxyphenyl-propylpiperidine) or K- (U 50488) opiate sites had a low affinity (Ki greater than 0.5 microM) for 3H-lofentanil specific binding sites.
(9) Related compounds including [D-Ala2, D-Leu5]enkephalin (DADLE), n-allylnormetazocine and phencyclidine were also examined.
(10) Phencyclidine residues were found in the brains of rat pups of mothers dosed with this drug during pregnancy.
(11) For 15 unselected urines the concentrations of phencyclidine showed no significant correlation with urinary pH.
(12) However, at high doses, DTG selectively suppressed the potentiation induced by a low dose of DTG and reduced the NMDA response below base line, presumably due to its low affinity for phencyclidine sites.
(13) Phencyclidine, which is an indirect dopaminergic agonist in the caudate, caused inhibition of the discharges of caudate neurons resembling that induced by dopamine itself.
(14) Significantly more blunting of the response of TSH to TRH was shown in cocaine and phencyclidine abusers compared with that seen in controls.
(15) Recently, we reported the characterization of a selective sigma receptor ligand, 1,3-di-o-tolyl-guanidine (DTG), that shows negligible crossreactivity with phencyclidine receptors.
(16) Phencyclidine had a biphasic effect on overall response rates in both components: response rates increased and then decreased as the dose was increased.
(17) The effects of phencyclidine infusions on fixed-ratio responding were variable.
(18) One of the analogs, cis-2-hydroxymethyl-r-1-(N-piperidyl)-1-(2-thienyl) cyclohexane (5) was found to show a high affinity (IC50 = 16 nM) for the phencyclidine (PCP) binding sites, very close to that of TCP, and to be 38-fold more potent in binding than its trans isomer.
(19) In animals sedated with phencyclidine or ketamine the only significant difference detected was in the mean cell volume.
(20) [3H]N-1-(2-Thienyl)cyclohexyl-3,4-piperidine binding to the phencyclidine site associated with the N-methyl-D-aspartate receptor was reduced by 60-80% in all brain regions examined (P less than 0.001).
Veterinary
Definition:
(a.) Of or pertaining to the art of healing or treating the diseases of domestic animals, as oxen, horses, sheep, etc.; as, a veterinary writer or school.
Example Sentences:
(1) The Department of Herd Health and Ambulatory Clinic of the Veterinary Faculty (State University of Utrecht, The Netherlands) has developed the VAMPP package for swine breeding farms.
(2) A suggestion is made to transfer the veterinary establishments from the agro-industrial complexes to the community systems, with responsibilities and rights of their own for the entire and dependable veterinary service in aid of the community systems.
(3) Of these 1224 prescriptions, 82.8% were for veterinary preparations, 6.6% were for human preparations and 10.6% were for other drugs.
(4) The information service provided by the Review of Medical and Veterinary Mycology is described and compared with other information services.
(5) The fundamental principles of genetic manipulation are explained, as are the methods of production of vaccines of veterinary importance.
(6) The properties of VISF indicate that the mechanism of MCMV immune suppression is different from that caused by several other viruses which are important in human and veterinary medicine.
(7) Challenge studies using the standard National Veterinary Services Laboratory laryngotracheitis (LT) challenge virus (Log 10(6.7) EID50 per ml) were conducted to assess the presence of maternal protection in chicks of various ages (1, 7, 14, 21, and 28 days).
(8) The first contribution in this field dates from 1961, and suggested a new approach to teaching Veterinary Public Health.
(9) If we are to attend to the entire health needs of our geriatric patients, then a thorough knowledge of veterinary dentistry is absolutely necessary.
(10) Scientific community of nations on our continent concerns also our discipline-veterinary medicine-giving numerous examples of common aims, beginning from the 1st Veterinary Congress in 1863, Hamburg.
(11) Serial Brucella agglutination tests were carried out on veterinary students at Bristol University between 1962 and 1968.
(12) The highest cost for veterinary services related to episodes of disease were for dystocia, lameness, and ocular carcinoma.
(13) Gastric drainage procedures are commonly used in veterinary medicine, particularly in dogs in attempts to prevent recurrence of gastric dilatation-volvulus (GDV).
(14) Moreover, veterinary help, the necessary use of drugs, the supervision and control of AID (Agricultural Inspection Services) and RVV (Inspection Service for Meat and Meat Products) add to the already substantial costs of modern animal husbandry.
(15) But Ward said the findings “emphasise the need for strict biosecurity measures in the food production industry and the importance of infection control measures in hospitals, as well as responsible antibiotic usage in both veterinary and human medicine”.
(16) Furthermore, its prevalence among veterinary isolates was significantly higher than among human isolates.
(17) During the past 20 years the equine population of Great Britain and Ireland has increased with the result that the practising veterinary surgeon is more frequently called upon to advise on equine problems.
(18) Allergic contact dermatitis to nitrofurazone has been reported from Europe and elsewhere from the use of eyedrops and topical ointments, and the drug in some livestock feeds and veterinary medications has caused a few cases of allergic contact dermatitis in humans.
(19) "Ecosystem health," an emerging science paralleling human and veterinary medicine, has as its goals the systematic diagnosis and treatment of stressed ecosystems.
(20) Twenty-five years of persistent research at the Jena Institute of Bacterial Animal Diseases have yielded substantive results of relevance to general knowledge and veterinary practice in the following fields: Mycoplasma species in farm animals-isolation, demands on culturing substrate, and differentiation; Virulence testing; Development, production, and application of diagnostic preparations; Development to full application maturity of diagnostic techniques and concepts for control of several mycoplasmal infections of relevance in terms of economy.