What's the difference between phorone and unsaturated?
Phorone
Definition:
(n.) A yellow crystalline substance, having a geraniumlike odor, regarded as a complex derivative of acetone, and obtained from certain camphor compounds.
Example Sentences:
(1) The concentration of nonprotein sulfhydryls in the nasal respiratory mucosa of phorone-injected rats was decreased to 10% of that of corn oil-injected rats.
(2) The metabolic incorporation of 3HCHO and H14CHO into DNA, RNA, and proteins in the respiratory and olfactory mucosa and bone marrow (femur) was significantly decreased, and DNA-protein crosslinking was significantly increased in the respiratory mucosa of phorone-injected relative to corn oil-injected rats at all HCHO concentrations.
(3) Phorone also produced an increase in spermidine content and a decrease in spermine content.
(4) Immunoblot analysis of microsomes isolated from phorone-treated hepatocytes did not reveal any partial proteolysis which might have accounted for the activation.
(5) This increase in enzyme activities was several-fold higher and longer lasting in rats pretreated with phorone.
(6) Moreover, unlike the depletion of hepatic GSH, brain GSH was markedly decreased by 2-cyclohexene-1-one and phorone, but not by buthionine sulfoximine.
(7) Thus, assessment of APDM activity and formaldehyde metabolism did not unequivocally establish the mechanism(s) by which CO2 evolution from aminopyrine is depressed by DEM, phorone and BSO, although low GSH is likely to impair metabolism of formaldehyde formed in liver after demethylation of aminopyrine.
(8) Animals treated with phorone exhibited decreases in lung glutathione concentration two hours after dosing and increases in lung glutathione concentration 24 hours after dosing.
(9) These observations are discussed with respect to the effects of phenobarbital, phorone and CCl4 on microsomal and cytosolic GSH-dependent enzymes involved in the metabolism of AA.
(10) There were also no significant differences in lactate dehydrogenase and thiobarbituric acid reactive substances (TBARS) release between the control and phorone-treated livers during reperfusion after various times of ischemia.
(11) Furthermore, prior depletion of hepatic glutathione by pretreatment with phorone markedly potentiated the hepatotoxicity of o- and m-DCB, while increasing the toxicity of p-DCB to a far lesser degree.
(12) Experiments were carried out to evaluate the effects of diethyl maleate or phorone, agents that deplete GSH from the liver, on the oxidation of formaldehyde.
(13) Administration of phorone (diisopropylidene acetone), an industrial solvent, to mice caused a rapid depletion of hepatic glutathione, which is due to enzymatic conjugation of phorone with glutathione, mediated by cytoplasmic enzymes of the liver.
(14) Furthermore, the glutathione depletion caused by phorone does not seem to be responsible for activation per se, since other thiol depletors [e.g.
(15) However, combined pretreatments of mice with either phorone or beta-naphthoflavone and the cytochrome P-448 inhibitor 9-hydroxyellipticine resulted in an increased overall retention of radioactivity in the body.
(16) The mechanism of the protection by phorone pretreatment against ANTU-induced pulmonary toxicity is unclear.
(17) Mitochondria isolated from rats treated in vivo with diethyl maleate or phorone had a decreased capacity to oxidize either formaldehyde or acetaldehyde.
(18) Cyclohexene, cycloheptene, phorone, acetaminophen, and benzyl chloride caused mild depletion of cerebral GSH, but buthionine sulfoximine did not alter cerebral GSH levels.
(19) Unlike this agent, however, phorone did not affect the microsomal mixed-function oxidase system at all.
(20) Only the combined treatment of phorone + ferrous sulfate or BCNU caused a significant increase of the diquat-induced liver injury.
Unsaturated
Definition:
(a.) Capable of absorbing or dissolving to a greater degree; as, an unsaturated solution.
(a.) Capable of taking up, or of uniting with, certain other elements or compounds, without the elimination of any side product; thus, aldehyde, ethylene, and ammonia are unsaturated.
Example Sentences:
(1) An unsaturated fatty acid auxotroph of Escherichia coli was grown with a series of cis-octadecenoate isomers in which the location of the double bond varied from positions 3 to 17.
(2) Substances with a leaving group at the C-3 position form unsaturated conjugated cyclic adducts and are mutagenic only in the His D3052 frameshift strains with an intact excision repair system (no urvA mutation).
(3) In general, optimal DAGAT activity in vitro was observed when long-chain unsaturated acyl-CoAs and diacylglycerols (DAGs) containing long acyl chains were used as substrates for in vitro TAG synthesis (although 1,2-didecanoin was also very effective).
(4) Saturated acyl residues predominated in lysolecithin and unsaturated ones in acids released by hydrolysis of egg lecithin.
(5) The content of unsaturated fatty acids in walleye pollock PRM is 1.4 times greater than in frog PRM.
(6) Taken together with other physical studies on the effect of vitamin E on (unsaturated) phospholipids, these results indicate that vitamin E could influence the physical properties of membrane phospholipids in addition to its known antioxidant role.
(7) Partially purified fatty acid synthetase produced saturated and unsaturated fatty acids with chain lengths of C10 to C18.
(8) The phosphatidylcholine and phosphatidylethanolamine had distinctive fatty acid distributions for position sn-2 of the triacylglycerol had a predominance of unsaturated fatty acids of which 18:1 (69.9%) was the major component.
(9) Alternatively, the data presented herein strongly suggest that diets containing conventional quantities of fat, in which saturated fat is replaced by unsaturated fat and dietary cholesterol reduced, would result in the desired reductions to total and low-density lipoprotein cholesterol concentrations without the adverse effects of increased postprandial glucose and insulin concentrations, increased fasting and postprandial total and very-low-density lipoprotein triglyceride concentrations, and decreased fasting high-density lipoprotein cholesterol concentrations.
(10) While undoubtedly a good understanding of soil microbiology in terms of pedology exists, little is presently known about unsaturated subsoils, and aquifers.
(11) In the intact neutrophil, this enzyme can be activated by increases in cytosolic calcium, protein kinase C, and unsaturated fatty acids such as arachidonic acid, all of which are produced on stimulation by chemotactic peptides like N-formyl-methionyl-leucyl-phenylalanine.
(12) In 8 of 11 patients no changes occurred in excretion of bile acids during the period on unsaturated fat when plasma cholesterol was declining.
(13) linoleic and gamma-linolenic acid also inhibited its secretion, whereas saturated fatty acid and mono-unsaturated fatty acids, such as oleic acid, were without effect.
(14) Patients under caloric restriction showed a reduction in their total triglyceride content, a reduction in their content of unsaturated fatty acyl groups, and a relative increase in phospholipid content.
(15) Protons and divalent cations show synergistic effects on the destabilization of liposomes composed of unsaturated phosphatidylethanolamine and oleic acid (Düzgünes et al., Biochemistry (1985) 24, 3091).
(16) 3H-acetyl CoA is more intensively used in the synthesis of unsaturated fatty acids than 14C-acetyl CoA synthesized from acetate.
(17) Amides containing an epoxy group exhibit a broad spectrum of antimicrobial activity which is further enhanced by unsaturation.
(18) The same enzyme biosynthesises saturated and mono-unsaturated very long chain fatty acids.
(19) In the infected chicks also the transferrin saturation was significantly lower and the unsaturated ironbinding capacity higher, on days 4, 6, and 8 after infection.
(20) Alcohol dehydrogenase purified by CM-cellulose chromatography from the sera of patients with hepatoma had a higher affinity for butanol long chain saturated and unsaturated alcohols than the purified enzyme from healthy controls.