(1) The incorporation of phosphine and phosphite ligands is described.
(2) In connection with this study, deoxyribonucleoside-3' dimethyl phosphites were synthesized and detailed properties of them are also described.
(3) The passive net transport of Li+ and Na+ across the human red cell membrane was accelerated by the divalent anions carbonate, sulphite, oxalate, phosphite and malonate.
(4) A period of adaptation was required prior to growth on phosphite when phosphate-grown cells were transferred to a medium containing a limiting amount of phosphate and excess phosphite.
(5) No phosphite-oxidizing activity could be detected in whole cells or cell-free extracts of phosphate-grown cells.
(6) The pH maxima observed for the phosphate analogs indicate a pK for this site of 5.5 at 37 degrees C. Intracellular pH changes associated with influx indicated that transport of the "fast" anion phosphite is largely in monoionized form.
(7) Adaptation to hypophosphite, however, led simultaneously to phosphite adaptation, so that these cells can utilize both P-compounds as a substitute for phosphate.
(8) The data show that detritylation and oxidation are side reactions which occur during the synthesis of monomeric units used in the construction of oligodeoxyribonucleotides by the phosphite triester method.
(9) It was shown that all 5'-phosphites effectively inhibit the production of viral antigens and protect cells from the cytotoxic effect of HIV infection.
(10) 2-(2-Pyridyl)ethyl group is a new type P-O protecting group for the synthesis of oligodeoxyribonucleotides by the phosphite triester method.
(11) Trimethyl and triethyl phosphites have general toxic effects.
(12) The naturally occurring DNA-nucleopeptide H-Asp-Ser[5'-pAAAGTAAGCC-3']-Glu-OH was prepared via a solid-phase phosphite triester approach using N-2-(tert-butyldiphenylsilyloxymethyl)benzoyl protected nucleosides.
(13) A gene coding for human stefin B was synthesized by the solid-phase phosphite method and cloned in the pUC8 cloning vector.
(14) Assays for phosphite removal by dilution or dialysis do not reverse the inhibition.
(15) The observed adaptation pattern, reflected by the alterations of phosphatase activity, was qualitatively equal with PO3-3 and PO3-2, but quantitatively different, because the response to hypophosphite gave much higher values than the increase obtained with phosphite.
(16) Data on the decreased toxicity of the phosphite mixture are explained from the viewpoint of a decreased pool disbalance of natural 2'-deoxynucleoside 5'-triphosphates in cells; a significant pool disbalance is developed in the case of 3'-azido-2',3'-dideoxythymidine action.
(17) Phosphonoacetaldehyde hydrolase inactivation by phosphite ion appears to be inconsistent with the concept of a Schiff base intermediate as proposed for Bacillus cereus enzyme.
(18) Reaction of 18 or 19 with triethyl phosphite gave, after deprotection, 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexyl-phosphonic acid (5), and reaction of 19 with potassium cyanide gave, after subsequent hydrolysis and deprotection, 7-(2,4-dichlorophenyl)-D-erythro-3-hydroxy-5-heptanolide (3).
(19) Triphenyl phosphite (TPP)-induced delayed neurotoxicity, which is thought to resemble but somewhat differ from classical organophosphate-induced delayed neurotoxicity (OPIDN), is known to be age-dependent.
(20) Previous studies in mammals have found that exposure to triphenyl phosphite results in cellular and axonal degeneration in the spinal cord and medulla.
Phosphorus
Definition:
(n.) The morning star; Phosphor.
(n.) A poisonous nonmetallic element of the nitrogen group, obtained as a white, or yellowish, translucent waxy substance, having a characteristic disagreeable smell. It is very active chemically, must be preserved under water, and unites with oxygen even at ordinary temperatures, giving a faint glow, -- whence its name. It always occurs compined, usually in phosphates, as in the mineral apatite, in bones, etc. It is used in the composition on the tips of friction matches, and for many other purposes. The molecule contains four atoms. Symbol P. Atomic weight 31.0.
(n.) Hence, any substance which shines in the dark like phosphorus, as certain phosphorescent bodies.
Example Sentences:
(1) In the liver of albino rats with experimental thyrotoxicosis a study was made of nucleic acids and some indices of phosphorus metabolism: total and inorganic phosphorus, total and acid-soluble phosphorus, phosphorus of RNA, DNA and phosphoproteins.
(2) Hypertonic saline infusion induced significant (P less than 0.05) increases in serum Na and Cl concentrations and osmolality, whereas ISS induced a significant increase in serum Cl concentration and a significant decrease in serum phosphorus concentration.
(3) A low-protein, low-phosphorus diet supplemented with essential amino acids and keto analogues was given to 12 rats, starting from the 90th day after subtotal nephrectomy.
(4) In comparison with native counterparts, the in vitro-formed LDL2 and HDL + VHDL were characterized by lower levels of triglyceride and cholesterol ester and higher levels of free cholesterol and lipid phosphorus.
(5) Unsupplemented human breast milk may not provide sufficient calcium and phosphorus for the rapidly growing preterm infant to match the accumulation that should have taken place in utero and to permit normal bone mineralization.
(6) In 9 other patients studied 2-7 years after transplantation the mean level of parathormone was lower than in the previous group but levels above normal were noted in half of the patients, some of which had perfect renal function and normal serum phosphorus.
(7) The treatment regimens used were chemotherapy in 9 patients, antiaggregating agents in 7, radioactive phosphorus in 1, the newer platelet-lowering agent anagrelide in 10, and only observation in 29.
(8) Phosphorus in fibrinogen did not correlate with fibrinogen degradation products or fibrinogen levels and became normal on adequate anticoagulation.
(9) The effect of age of the ewe and pregnancy on concentrations of plasma calcium, phosphorus and magnesium and its relationship to the bent-leg syndrome in lambs, were investigated.
(10) Reports in the past two years have appeared evaluating the clinical use of phosphorus spectroscopy to detect ischemic heart disease, cardiomyopathy, and cardiac transplant rejection.
(11) Blood calcium and phosphorus, parathyroid hormone, urinary excretion of calcium were determined.
(12) The raw data are obtained by capillary gas chromatography using a nitrogen-phosphorus detector.
(13) In order to examine the mechanisms underlying radiation-induced changes in phosphorus metabolite levels observed in RIF-1 tumors in vivo, RIF-1 cells in culture were perfused for up to 70 h following gamma-irradiation with 0-25 Gy and monitored continuously by 31P NMR spectroscopy at 8.5 T. Cells immobilized in the sample volume by incorporation into calcium alginate beads were bioenergetically stable, but did not replicate at the cell density used.
(14) With increasing H2O2 concentration in the perfusion media there was a corresponding decrease in the observed phosphorus metabolites, phosphorylcholine and ATP.
(15) All calcium, magnesium, and zinc contents per bone decreased in the 1- and 2-mg caffeine groups as compared to either controls or 0.5-mg caffeine group, whereas phosphorus stayed relatively constant regardless of the different levels of caffeine intake.
(16) 77 p. 100 of those fluids present an antibacterial activity, but no correlation has been found with their concentration in zinc and phosphorus.
(17) The basal diet which contained .30% phosphorus and .21% calcium was adjusted to contain added phosphorus levels of 0, .05, .10, or .15%, with calcium levels of .49, .47, .57 and .61%, respectively.
(18) In 50% of the animals lactate increased prior to any change in the phosphorus metabolites or intracellular pH, suggesting that 1H NMR may be more sensitive than 31P NMR at detecting hypoxic or ischaemic changes.
(19) Ferrihydrite was the predominant form of iron present in both ferritin and haemosiderin, while haemosiderin contained higher amounts of phosphorus, magnesium, calcium and barium, then either normal or ferrocene-loaded ferritin.
(20) Plasma levels of both phosphorus and urate fell during this time.