What's the difference between phosphoryl and radical?
Phosphoryl
Definition:
(n.) The radical PO, regarded as the typical nucleus of certain compounds.
Example Sentences:
(1) Cyclic AMP stimulated phosphorylation by [gamma-32P]ATP of two proteins of apparent Mr = 20,000 and 7,000 that were concentrated in sarcoplasmic reticulum, but the stimulation was markedly dependent on the presence of added soluble cyclic AMP-dependent protein kinase.
(2) The p60v-src protein encoded by Prague Rous sarcoma virus was found to contain two sites of tyrosine phosphorylation.
(3) The time-course and dose-response for this modification of pp60c-src paralleled PDGF-induced increases in phosphorylation of pp36, a major cellular substrate for several tyrosine-specific protein kinases.
(4) An increase in membrane thickness was observed on phosphorylation.
(5) Further study both of the signaling events that lead to MPF activation and of the substrates for phosphorylation by MPF should lead to a comprehensive understanding of the biochemistry of cell division.
(6) The possible significance of this finding in relation to the mode of phosphorylation and glycosylation in vivo is discussed.
(7) Almost the same rate of phosphorylation was obtained with or without calcium in the incubation medium.
(8) The phosphorylation pattern was affected by the addition of cholera toxin or GDP beta S to the isolated nuclei.
(9) Amino acid analysis indicated a significant number of serine amino acids: N-terminal sequence data demonstrated a high level of homology; and trypsin digestion followed by reversed-phase HPLC indicated the possibility of multiple phosphorylation sites.
(10) The functions of O-GlcNAc remain largely unknown, but it may be important in blocking phosphorylation sites, it may be required for the assembly of specific multiprotein complexes, it might serve as a nuclear transport signal, or it may be directly involved in the active transport of macromolecules across nuclear pores.
(11) Although the brain AP50 is prominently phosphorylated by an endogenous protein kinase in isolated coated vesicle preparations, the neuronal AP50 was not detectably phosphorylated in intact cells as assessed by two-dimensional non-equilibrium pH gradient gel electrophoresis of labeled cells dissolved directly in SDS-containing buffers.
(12) Similarly, the phosphorylation potential, phosphocreatine, adenosine triphosphate, and cyclic adenosine monophosphate were constant in the range of autoregulation but decreased directionally with coronary perfusion pressure below 110 cm H2O for both SHR and WKY rats.
(13) This is the first evidence for phosphorylation-dependent binding of RAP1.
(14) In intact animals, GM1 treatment produced a reduction in cAMP and Ca2+ induced striatal protein phosphorylation.
(15) During the carcinogens metabolism compounds are assumed to be formed, those are able to affect oxidative phosphorylation without forming any stable link with the respiratory chain components.
(16) The activation of calcium uptake by increasing concentrations of trypsin was paralleled by the reduction of phosphorylation of phospholamban.
(17) In vivo labeling with 32Pi showed that plectin was the target for cAMP-independent protein kinases which phosphorylated 18-kDa domains at the end(s) of the molecule.
(18) Comparison of the native and derivatized wheat germ CaMs with native bovine testis CaM indicates that the concentrations of these proteins required for half-maximal stimulation of either erythrocyte membrane Ca2+-ATPase activity or cardiac sarcoplasmic reticulum phosphorylation are very similar.
(19) The narX gene product may be involved in sensing nitrate and phosphorylating NARL.
(20) Changes in protein phosphorylation induced by phagocytic challenge were identified in cultured rat retinal pigment epithelium (RPE) following exposure to isolated rat rod outer segments (ROS) or to polystyrene latex microspheres (PSL).
Radical
Definition:
(a.) Of or pertaining to the root; proceeding directly from the root.
(a.) Hence: Of or pertaining to the root or origin; reaching to the center, to the foundation, to the ultimate sources, to the principles, or the like; original; fundamental; thorough-going; unsparing; extreme; as, radical evils; radical reform; a radical party.
(a.) Belonging to, or proceeding from, the root of a plant; as, radical tubers or hairs.
(a.) Proceeding from a rootlike stem, or one which does not rise above the ground; as, the radical leaves of the dandelion and the sidesaddle flower.
(a.) Relating, or belonging, to the root, or ultimate source of derivation; as, a radical verbal form.
(a.) Of or pertaining to a radix or root; as, a radical quantity; a radical sign. See below.
(n.) A primitive word; a radix, root, or simple, underived, uncompounded word; an etymon.
(n.) A primitive letter; a letter that belongs to the radix.
(n.) One who advocates radical changes in government or social institutions, especially such changes as are intended to level class inequalities; -- opposed to conservative.
(n.) A characteristic, essential, and fundamental constituent of any compound; hence, sometimes, an atom.
(n.) Specifically, a group of two or more atoms, not completely saturated, which are so linked that their union implies certain properties, and are conveniently regarded as playing the part of a single atom; a residue; -- called also a compound radical. Cf. Residue.
(n.) A radical quantity. See under Radical, a.
(a.) A radical vessel. See under Radical, a.
Example Sentences:
(1) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(2) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(3) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
(4) The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of O2 radicals and an inhibitor of xanthine oxidase.
(5) Flow cytometric DNA analysis was performed on both fresh and on paraffin embedded samples obtained by gastroscopic biopsies in 5 patients with histologically normal gastric mucosa (20 specimens) and by radical gastrectomies in 9 cases of human gastric cancer (36 specimens).
(7) Residual cancer was found in the radical prostatectomy specimen in 11 of the 29 stage-A1 patients (38%) and in 66 of the 86 stage-A2 patients (77%).
(8) This may be due to DMSO's ability to scavenge free radicals.
(9) A more radical surgery is recommended but with the limitation that the operative method must be adapted to the operative finding.
(10) The present study explored the possibility that SOD-mimics such as desferrioxamine-Mn(III) chelate [DF-Mn] or cyclic nitroxide stable free radicals could protect from O2-.-independent damage.
(11) Treatment modalities included: partial temporal bone resection, subtotal temporal bone resection, total temporal bone resection, radical mastoidectomy followed by radiation therapy, radiation therapy alone, and chemotherapy.
(12) Leaders of Tory local government are preparing radical proposals for minimum 10% cuts in public spending in the search for savings.
(13) Plays like The Workhouse Donkey (1963) and Armstrong's Last Goodnight (1964) were staged in major theatres, but as the decade progressed so his identification with the increasingly radical climate of the times began to lead away from the mainstream theatre.
(14) 78% of the recurrences were seen two years postoperatively and 27% were asymptomatic; 10% underwent radical operation, 27% palliative operation and 63% conservative treatment.
(15) The kinetics of bimolecular decay of alpha-tocopheroxyl free radicals (T) was studied by ESR mainly in ethanol and heptanol solvents.
(16) While the correlations between speed and accuracy reversed over time, the abnormal vision group began and ended at the most extreme levels, having undergone a significantly more radical shift in this regard.
(17) NPR reported that investigators have not found telltale signs associated with Islamist radicalization , such as a change in mosques or abrupt shifts in behavior or family associations.
(18) The second triplet, which was stable in the dark at 4.2 K following illumination, was assigned to the radical pair Donor+I-.
(19) It may be due to relative nonreactivity of ascorbic acid free radical that free radical chain reactions, found commonly in radical chemistry, do not occur in the scavenging reaction by ascorbic acid.
(20) The free radical scavengers mannitol, thiourea, benzoate, and 4-methylmercapto-2-oxobutyrate protected either native cells exposed to H2O2 or pretreated hepatocytes exposed to H2O2 and given ferric or ferrous iron.