What's the difference between physostigmine and reversible?
Physostigmine
Definition:
(n.) An alkaloid found in the Calabar bean (the seed of Physostigma venenosum), and extracted as a white, tasteless, substance, amorphous or crystalline; -- formerly called eserine, with which it was regarded as identical.
Example Sentences:
(1) injection of the tertiary amine cholinesterase inhibitor physostigmine (17-70 micrograms kg-1) induced a prompt, sustained and dose-dependent improvement of cardiovascular and respiratory function, with marked increase in the volume of circulating blood and survival of all treated animals, at least for the 2 h of observation.
(2) Drugs known to improve memory, including physostigmine, pramiracetam and the muscarinic agonists, oxotremorine and RS 86, selectively induced analgesia in rats subjected to test before the shock plus the shock, thereby supporting a hypothesis of avoidance learning.
(3) Plasma and brain containing physostigmine were first precipitated with TCA, and then carbaryl was added.
(4) In the presence of physostigmine the two sources of stimuli were equally effective.
(5) The study of the drugs effective in the treatment of cognitive deficits and memory loss associated with senile dementia of the Alzheimer's type--tacrine and amiridin, acetylcholinesterase inhibitor physostigmine and nootrop piracetam on uptake of 3H-serotonin (3H-5-HT), 3H-adrenaline (3H-AD), 3H-noradrenaline (3H-HA), 2H-dopamine (3H-DA), 3H-gamma-aminobutyric acid (3H-GABA), 3H-glutamic acid (3H-GLU), 3H-aspartic acid (3H-ASP) and 3H-glycine (3H-GLI) showed that tacrine and amiridin (5 x 10(-5) M) statistically significantly (P less than 0.05) inhibited the uptake of 3H-DA and 3H-5-HT.
(6) The present results demonstrate that either the presurgical drug treatment (desmethylimipramine and pentobarbital) or 7 days isolation was alone sufficient to reduce the yawning response to physostigmine and abolish its potentiation by nifedipine.
(7) Predicted concentrations of physostigmine in different tissue compartments were consistent with the experimental observations in the rat following an iv dose.
(8) Acute exercise modifies the effect of physostigmine significantly (p less than 0.01) by increasing the cholinesterase inhibition in red blood cells and brain without affecting other tissues.
(9) The time of survival of DFP exposed animals increased after pretreatment with carbamates, more after physostigmine (81 min) than after pyridostigmine (59 min).
(10) To examine the efficacy of cholinergic enhancement in senile dementia of the Alzheimer type (SDAT), oral physostigmine was given to eight patients in a cross-over trial of three dose levels and a matching placebo.
(11) In a group of the MS-DB units with stable background theta bursts the typical response consisting of entrainment of the phase-locked theta cycles was changed neither by physostigmine, nor by cholinergic-blocking drugs (scopolamine and atropine).
(12) Aimed at the centralized manufacture of physostigmin salicylate injection solutions, the efficacy of different stabilizators has been studied under conditions of the thermic load.
(13) The kinetics of the nicotine effects on uptake were different from those of physostigmine.
(14) For example, scopolamine elicits increased locomotor activity, an action which is attenuated by glucose and by combined treatment with glucose and physostigmine at doses which are individually without effect.
(15) The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys.
(16) After oral physostigmine administration the following morning, the majority of patients experienced side effects such as nausea and abdominal pain.
(17) To assess the efficacy of oral physostigmine for the treatment of Alzheimer's disease, 20 patients were entered into a clinical trial.
(18) These retention deficits could be reversed by the postacquisition administration of the acetylcholinesterase inhibitor, physostigmine.
(19) Atropine reduced the dopamine-induced secretion significantly, and physostigmine enhanced the secretion.
(20) Serum butyrylcholinesterase (EC 3.1.1.8) appears to be responsible for this hydrolysis, as evidenced by its inhibition by physostigmine and catalysis by commercially available pseudocholinesterase from horse and human blood.
Reversible
Definition:
(a.) Capable of being reversed; as, a chair or seat having a reversible back; a reversible judgment or sentence.
(a.) Hence, having a pattern or finished surface on both sides, so that either may be used; -- said of fabrics.
Example Sentences:
(1) This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline.
(2) Application of 40 microM NiCl2 reversibly blocked It while leaving Is intact, whereas 20 microM CdCl2 reversibly blocked Is, but not It.
(3) The outward currents are sensitive to TEA and their reversal potentials differ.
(4) With NaCl as the major constituent of the bathing solution (potassium-free pipette and external solutions) the reversal potential (Er) of the noradrenaline-evoked current was about 0 mV.
(5) The HBV infection was tested by the reversed passive hemagglutination method for the HBsAg and by the passive hemagglutination method for the anti-HBs at the time of recruitment in 1984.
(6) If the method was taken into routine use in a diagnostic laboratory, the persistence of reverse passive haemagglutination reactions would enable grouping results to be checked for quality control purposes.
(7) Tests showed the cells survive and function normally in animals and reverse movement problems caused by Parkinson's in monkeys.
(8) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(9) Head-injured patients had a low thyroxine (T4), low triiodothyronine (T3), and high reverse T3.
(10) Dilutional studies comparing the mechanism of inhibition of monoamine oxidase produced by Gerovital H3 and by ipronizid demonstrated that Gerovital H3 was a reversible inhibitor of monoamine oxidase.
(11) Nucleotide, which is essential for catalysis, greatly enhances the binding of IpOHA by the reductoisomerase, with NADPH (normally present during the enzyme's rearrangement step, i.e., conversion of a beta-keto acid into an alpha-keto acid, in either the forward or reverse physiological reactions) being more effective than NADP.
(12) An axillo-axillary bypass procedure was performed in a high-risk patient with innominate arterial stenosis who had repeated episodes of transient cerebral ischemia due to decreased blood flow through the right carotid artery and reversal of blood flow through the right vertebral artery.
(13) What reforms there were could also be reversed, she warned.
(14) No reversions to wild-type levels were observed in 555 heterozygous offspring of crosses between homozygous Campines and normals.
(15) We have compared two new methods (a solvent extraction technique and a method involving a disposable, pre-packed reverse phase chromatography cartridge) with the standard method for determining the radiochemical purity of 99Tcm-HMPAO.
(16) Sickle and normal discocytes both showed membrane elasticity with reversion to original cell shape following release of the cell from its aspirated position at the pipette tip.
(17) These antagonists reverse NMDA-mediated long term influence in these brain areas.
(18) For dental procedures requiring tracheal intubation, one could perhaps use non-depolarizing muscle relaxants, like pancuronium, with reversal at the end of the procedure.
(19) We have recently described a nonnucleoside compound that specifically inhibits the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS.
(20) We have investigated some of the factors which affect the retention times of these substances in reversed-phase HPLC on columns of 5-micron octadecylsilyl silica.