What's the difference between picrotoxin and stimulant?
Picrotoxin
Definition:
(n.) A bitter white crystalline substance found in the cocculus indicus. It is a peculiar poisonous neurotic and intoxicant, and consists of a mixture of several neutral substances.
Example Sentences:
(1) Other characteristics of the LHP that were demonstrated include: a lack of blockage by GABAA receptor antagonists, a probable voltage sensitivity (decrease in amplitude in the depolarizing direction), and an apparent brief onset latency (less than 10 ms) when the early IPSP was blocked by picrotoxin.
(2) The results are interpreted as follows: picrotoxin released dopamine through disinhibition of the dopaminergic neurons as a result of blockade of gabergic receptors.
(3) This conductance increase was blocked by picrotoxin over a range of concentrations similar to those required for blockade of the GABA-induced response.
(4) Picrotoxin (50 microM) induced spontaneous bursts of repetitive spiking, followed by a slow, negative field potential, associated with spreading depression (SD), in slices from immature animals.
(5) 's are reversibly abolished by the application of picrotoxin and gamma-aminobutyric acid.
(6) The response was blocked by picrotoxin in a noncompetitive manner.
(7) However, picrotoxin and beta-guanidinopropionic acid block the response to pressure-applied GABA but do not block the response to light even at an order of magnitude higher concentration.
(8) Synchronous firing was initiated by stimulating stratum radiatum fibers in the presence of picrotoxin.
(9) The effect of baclofen was antagonized by a low dose of 4-aminopyridine (5 X 10(-6) M) whereas it was unaffected by picrotoxin (2 X 10(-5) M).
(10) 5 alpha-Pregnan-3 alpha-ol-20-one protected mice against metrazol-, bicuculline- and picrotoxin-induced seizures but not against electroshock-and strychnine-induced seizures.
(11) Putative blockers of the GABA-receptor coupled chloride channel, picrotoxin and pentylenetetrazol, and the benzodiazepine receptor antagonists Ro 15-1788 and CGS 8216 each blocked the anxiolytic effect of chlordiazepoxide.
(12) It is possible that Ro 5-4864 exerts its convulsant action at the picrotoxin site of the central Bz receptor - gamma-aminobutyric acid receptor-chloride ionophore complex.
(13) Implants containing 10% estradiol in cholesterol were less effective in protecting against picrotoxin-induced seizures.
(14) injection of hypertonic solutions of GABA and mannitol on convulsant activity and latency to reduced or enhanced depending on whether picrotoxin was given i.p.
(15) From a comparison of activation by strychnine and picrotoxin in normal and chronically decapitated embryos it was deduced that a spinal and a supraspinal component participated in their effect.
(16) The locomotion reducing effects of naloxone could be blocked by either picrotoxin or bicuculline.
(17) The GABA receptor antagonist, bicuculline, and the blockers of the GABA-receptor-coupled chloride channel, picrotoxin and pentylenetetrazol, produced a dose-dependent proconflict effect.
(18) In the second test, the cats injected with picrotoxin crossed to the other compartment while the subjects injected with saline did not move.
(19) The immediate posttraining administration of the GABA antagonist, bicuculline, or of the Cl-channel blockers, picrotoxin or Ro 5-4864, enhances memory.
(20) The action of strychnine and picrotoxin on the values of different reflex components was not identical; this pointed to a different localization of the inhibitory action of GABA and glycine in the central link of the somatosympathetic reflex arch.
Stimulant
Definition:
(a.) Serving to stimulate.
(a.) Produced increased vital action in the organism, or in any of its parts.
(n.) That which stimulates, provokes, or excites.
(n.) An agent which produces a temporary increase of vital activity in the organism, or in any of its parts; -- sometimes used without qualification to signify an alcoholic beverage used as a stimulant.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) The optimal size for stimulation was between 5 degrees and 12 degrees (visual angle).
(3) After stimulation with lipopolysaccharide and calcium ionophore A23187, culture supernatants of clones c18A and c29A showed cytotoxic activity against human melanoma A375 Met-Mix and other cell lines which were resistant to the tumor necrosis factor, lymphotoxin and interleukin 1.
(4) Apparently, the irradiation with visible light of a low intensity creates an additional proton gradient and thus stimulates a new replication and division cycle in the population of cells whose membranes do not have delta pH necessary for the initiation of these processes.
(5) In conclusion, in S-rats a glucose-stimulated insulin release is accompanied by an increase in IBF, but this is not observed in P-rats.
(6) Stimulation is also observed with mixtures of APC expressing DPw3 and APC expressing A1, and likewise, DPw3+ APC become stimulatory when preincubated with supernatants from A1-positive cells.
(7) We have previously shown that serotonin is present in secretory granules of frog adrenochromaffin cells; concurrently, we have demonstrated that serotonin is a potent stimulator of corticosterone and aldosterone secretion by adrenocortical cells.
(8) Cyclic AMP stimulated phosphorylation by [gamma-32P]ATP of two proteins of apparent Mr = 20,000 and 7,000 that were concentrated in sarcoplasmic reticulum, but the stimulation was markedly dependent on the presence of added soluble cyclic AMP-dependent protein kinase.
(9) We have investigated a physiological role of endogenous insulin on exocrine pancreatic secretion stimulated by a liquid meal as well as exogenous secretin and cholecystokinin octapeptide (CCK-8) in conscious rats.
(10) Whether hen's egg yolk can be used as a sperm motility stimulant in the treatment of such conditions as asthenospermia and oligospermia is subjected for further study.
(11) Some of those drugs are able to stimulate the macrophages, even in an aspecific way, via the gut associated lymphatic tissue (GALT), that is in connection with the bronchial associated lymphatic tissue (BALT).
(12) The results also suggest that the dispersed condition of pigment in the melanophores represents the "resting state" of the melanophores when they are under no stimulation.
(13) dl-Methionine stimulated the synthesis of cephalosporins when added after the growth phase.
(14) Bradykinin also stimulated arachidonic acid release in decidual fibroblasts, an effect which was potentiated in the presence of epidermal growth factor (EGF), but which was not accompanied by an increase in PGF2 alpha production.
(15) Pokeweed mitogen-stimulated rat spleen cells were identified as a reliable source of rat burst-promoting activity (PBA), which permitted development of a reproducible assay for rat bone marrow erythroid burst-forming units (BFU-E).
(16) To investigate the mechanism of enhanced responsiveness of cholesterol-enriched human platelets, we compared stimulation by surface-membrane-receptor (thrombin) and post-receptor (AlF4-) G-protein-directed pathways.
(17) Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency.
(18) Because it has been suggested that the lathyrogen, BAPN, may stimulate the release of proteases, the protease inhibitors Trasylol and epsilon-aminocaproic acid (EACA) were given alone or in combination to BAPN-treated rats.
(19) The present study was designed to test the hypothesis that the decreased Epi response following ET was due to 1) depletion of adrenal Epi content such that adrenomedullary stimulation would not release Epi, 2) decreased Epi release with direct stimulation, i.e., desensitization of release, or 3) decreased afferent signals generated by ET itself.
(20) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.