(1) pIgG, independent of its effect on insulin binding, inhibited both basal and insulin-stimulated autophosphorylation of the insulin receptor in a dose-dependent manner with a half maximal effect at 3.3 to 7 micrograms protein.
(2) Moreover, these findings suggest that pIgG may inhibit autophosphorylation by acting on domains which are similar in the insulin and EGF receptors.
(3) The relative affinity of two mIgGs for human t-PA was found to be equal or even superior to that of pIgG.
(4) Furthermore, pIgG also reduced basal autophosphorylation of the EGF receptor.
(5) The immunoglobulin G of a polyclonal antiserum (pIgG) from a patient with insulin resistance and hypoglycemia was tested for its ability to inhibit insulin binding and to affect the autophosphorylation of partially-purified insulin receptors extracted from rat liver membranes.
(6) He seems tired of his tragic love life and can hardly bring himself to consummate an unsatisfying fling with his housing officer, Pamela Pigg.
(7) The effect of pIgG to inhibit basal autophosphorylation of insulin and EGF receptors, together with its ability to reduce autophosphorylation of insulin receptors fully occupied by insulin, imply that the effect of pIgG on receptor autophosphorylation is largely independent of its effect on ligand binding.
(8) A human polyclonal IgG (pIgG), previously characterized as anti insulin receptor antibody, able to inhibit insulin receptor kinase activity, was used to further investigate subunit homologies and differences in antigenicity and functional regulation between IGF I and insulin receptors, IGF I receptor tyrosine kinase was stimulated by a IGF I analog (aIGF I), produced by DNA recombinant technology, pIgG was able to inhibit IGF I receptor kinase activity, thus revealing antigenic homologies between the kinase domains of insulin and IGF I receptors.
(9) Using these products in DI together with antibodies against PIgG class- and subclass-specific determinants it was proven that at least two PIgG subclasses exist (tentatively called IgG1 and IgG2).
(10) Two of the fragments reacting with PIgG antisera remained intact even after 120 h digestion.
(11) pIgG, when added 4 hr prior to insulin, inhibited subsequent insulin binding by 50% at 30 micrograms added protein; however, insulin previously bound to the receptor could not be displaced by a 4 hr subsequent exposure of up to 70 micrograms pIgG.
(12) To investigate the existence of two or more porcine IgG (PIgG) subclasses PIgG was isolated from whey and serum by precipitation with caprylic acid followed by ion-exchange chromatography.
(13) Waugh's treatment of Pappenhacker is significant, because unlike some of the stock journalistic characters in Scoop – Shumble, Pigge, Whelper, even the capable Corker – he is treated as zealous in the pursuit of truth.
(14) However the more pronounced inhibition of IGF I receptor-compared with insulin receptor kinase activity by pIgG suggests the existence of different regulatory mechanisms.
(15) Coelomic fluids of E.F. digest effectively vertebrate serum proteins (PIgG, HSA) but not the proteins of L.T.
(16) Soon after, the jury was told, Floorgraphics began to lose crucial contracts with key clients – Safeway, Winn-Dixie, the South Carolina retail chain Piggly Wiggly and others – many of whom defected to News America.
(17) Six monoclonal antibodies (mIgG) and a polyclonal antibody (pIgG) directed against human tissue-type plasminogen activator (t-PA) were tested for their species specificity towards human or murine t-PA.
(18) A minimal coupling stoichiometry of 2.2 palmitic acids per IgG was essential for the stabilization activity of pIgG.
(19) In addition, the minimal pIgG to PE molar ratio for stable liposomes was 2.5 X 10(-4).
(20) Whereas pIgG as well as several mIgGs discriminated poorly between these two t-PA species, one mIgG (clone E3) was highly specific for human t-PA. Inhibition and binding studies of human t-PA by mIgGs revealed high affinity-high inhibitory (E3) as well as high affinity-poor inhibitory (B1) mIgGs.
Ping
Definition:
(n.) The sound made by a bullet in striking a solid object or in passing through the air.
(v. i.) To make the sound called ping.
Example Sentences:
(1) Crisis engulfs Gabon hospital founded to atone for colonial crimes Read more At least seven people died and more than 1,000 were arrested in violent protests following the announcement of the election result earlier this month, which the leader of the opposition, Jean Ping, said Bongo, the incumbent, had rigged.
(2) It is a waste of taxpayer’s money.” A third critic wrote: “What China’s National Football Team gives its fans is decades of consistent disappointment.” Some disillusioned fans called for Team China’s manager, Gao Hongbo, to be sacked and replaced with Lang Ping, the revered coach of China’s female volleyball team.
(3) The kinetic data are compatible with a tert-uni ping-pong mechanism, as in the case of the 'classical' glutathione peroxidase (EC 1.11.1.9).
(4) Hu Ping, a US-based editor and friend of Liu, asked why the international community was not doing more to secure his release.
(5) Initial-velocity kinetic studies indicate the enzyme acts by a ping-pong mechanism.
(6) Initial velocity and isotope exchange studies confirmed that the over-all reaction, like that catalyzed by pyruvate carboxylase purified from rat liver and chicken liver, was a nonclassical Ping Pong Bi Bi Uni Uni sequence with ATP and HCO3-binding randomly in the Bi Bi partial reaction.
(7) The asymptotic kinetics of lipoamide oxidoreductions switch between the ping pong and ordered mechanisms by varying pH of the reactions.
(8) The assurances we are getting from those that are protecting him is that he is not far from Bamako," Ping said.
(9) Penetration of these drugs into perforated ping pong balls implanted intraperitoneally in rabbits was studied.
(10) Rare is the interview that concludes with the subject pinging one’s bra strap.
(11) The results obtained were consistent with a ping-pong or substitution mechanism.
(12) Since each catalytic cycle step is irreversible, the data fit a peroxidase ping-pong mechanism rather than an ordered bi-bi ping-pong mechanism.
(13) And then, proving that in the celebrity world of self-abasement there really is no such thing as "bottoming out", Shane started tweeting Ping Pong, otherwise known as Elizabeth Hurley's parrot Why has Australia not staged an intervention?
(14) It seems most probable that, as previously suggested by others for Ts, eIF-2B effectively catalyses an exchange reaction through a "ping-pong" type mechanism.
(15) Right up until the 79th minute, when the substitute Ramires pinged a 25-yard shot beyond Tim Krul, Chelsea were unconvincing.
(16) Such distension results in an area of tympanic resonance or ping.
(17) Initial velocity studies indicate that the enzymatic reaction proceeds by a Ping-Pong mechanism.
(18) This reaction pathway is compared with the double displacement (Ping Pong) mechanisms that have previously been described for pyruvate carboxylases from other sources.
(19) The wild-type enzyme and Y177F mutant displayed ping-pong kinetics, but the Y177S and Y177G mutants appeared to have switched to an ordered sequential mechanism.
(20) But I don’t think [Lords chief whip] Ben Stoneham is going to be very accommodating to anyone.” Brexit weekly briefing: article 50 moves closer but EU dashes divorce deal hopes Read more Labour has promised no “extended ping pong” as it does not want to frustrate the timetable for triggering article 50, but it has laid eight amendments on issues from EU nationals to quarterly reporting to parliament about the Brexit process.