(n. pl.) The small, troublesome tumors or swellings about the anus and lower part of the rectum which are technically called hemorrhoids. See Hemorrhoids. [The singular pile is sometimes used.]
Example Sentences:
(1) Electron microscopy revealed the presence of a hitherto unreported peculiar "pilovacuolar" inclusion in numerous mitochondria, composed of an electron dense pile or rod within a vacuole, while globular or crystalline inclusions were absent.
(2) Piling refugees on trains in the hopes that they go far, far away brings back memories of the darkest period of our continent,” he told Der Spiegel.
(3) After the gunfight the marines made the shocking discovery of bodies of 58 men and 14 women in a room, some piled on top of each other.
(4) Chris Williamson, of data provider Markit, said: "A batch of dismal data and a gloomier assessment of the economic outlook has cast a further dark cloud over the UK's economic health, piling pressure on the government to review its fiscal policy and growth strategy.
(5) This is a substantial country, not just a pile of bricks.
(6) Then they become increasingly unable to afford the probation fees that are piled on by private companies paid to oversee them, including fees for everything from basic supervision to drug tests.
(7) For each indicated educational--motivating unity parents have to be completely prepared for better and more complete than usual piling of facts and presenting in front of them unsolvable tasks and obligations.
(8) According to its physical and biochemical properties, poly(L-malate) may alternatively function as a molecular chaperone in nucleosome assembly in the S phase and as both an inhibitor and a stock-piling agent of DNA-polymerase-alpha-primase in the G2 phase and M phase of the plasmodial cell cycle.
(9) You’d think such a spry, successful man would busy himself with other things besides crawling into a pile of stuffed animals to scare his daughter’s date.
(10) In the spare room, there was a pile of CVs aimed at charities to secure this “free labour” imposed by the benefits system.
(11) Vote for me, and I will complete the job of rebalancing it... January 28, 2014 12.03pm GMT Britain's businesses need to stop sitting on their cash piles and crank up their investment, argues IPPR’s chief economist Tony Dolphin: “The news that manufacturing is growing is welcome.
(12) There are 80,000 bars and restaurants there and they're often piled eight stories high on top of each other.
(13) Cards pile on the runs, and here comes Hurdle to get Burnett, about three batters too late.
(14) When my floor was dirty, I rose early, and, setting all my furniture out of doors on the grass, bed and bedstead making but one budget, dashed water on the floor, and sprinkled white sand from the pond on it, and then with a broom scrubbed it clean and white... Further - and this is a stroke of his sensitive, pawky genius - he contemplates his momentarily displaced furniture and the nuance of enchanting strangeness: It was pleasant to see my whole household effects out on the grass, making a little pile like a gypsy's pack, and my three-legged table, from which I did not remove the books and pen and ink, standing amid the pines and hickories ...
(15) Rather, it's because because policymakers and administrators have come to treat higher education as a commercial marketplace, rather than a public trust – and stop-gap student loan reforms like those "unveiled" by President Obama this week fail to confront this ethical dilemma underlying the debt pile.
(16) There is a half-drunk glass of white wine abandoned on the coffee table at his Queensferry home - the Browns had friends around for dinner the previous night - and a stack of children's books and board games piled lopsidedly under a Christmas tree now shedding needles with abandon.
(17) Signs that large companies are ready to start spending some of the cash piles they have been sitting on while smaller firms are prepared to borrow to expand reflect a brighter outlook for sales.
(18) Britain's Serious Fraud Office has launched a formal criminal investigation into GlaxoSmithKline's sales practices, piling further pressure on the drugmaker which is already being investigated by Chinese authorities and elsewhere amid allegations of bribery.
(19) After more than a quarter of a century of camping out, the house, with its seven flights of stairs (a trial to Lessing in her final years), seemed almost to be supported by a precarious interior scaffolding of piles of books and shelves.
(20) The ONS said UK's debt pile had risen to £1.11tn or 70.7% of GDP.
Pilus
Definition:
Example Sentences:
(1) Ultrastructural studies of Aeromonas hydrophila strain AH26 revealed two distinctive pilus types: "straight" pili appear as brittle, rod-like filaments, whereas "flexible" pili are supple and curvilinear.
(2) Phagocytic killing in the presence of each monoclonal antibody paralleled the increase in chemiluminescence, suggesting that for this variant killing was an inevitable consequence of the interaction of polymorphonuclear leukocytes with gonococci opsonized with anti-pilus antibodies.
(3) These results show for the first time the role of a specific pilus structure in colonization of the human intestine by V. cholerae O1 and exemplify the significance of a genetic regulon in pathogenesis.
(4) The relative affinity of these peptides for anti-EDP208 pilus antibodies was determined by a competitive enzyme-linked immunosorbent assay using the Fab fragment of anti-EDP208 pilus immunoglobulin G. From these results we established that the antigenic region of this peptide was the N-terminal pentapeptide, N-acetyl-Thr-Asp-Leu-Leu-Ala, and the key residues responsible for the antibody-antigen interaction are the N-acetyl-Thr1, Leu3, and Leu4.
(5) The antigenic surface-associated colonization factor of E. coli strain H-10407 has been further characterized: this pilus-like antigen is produced under conditions of growth that repress the production of common pili of E. coli.
(6) The degree of S-pilin processing and the levels of membrane-associated pilin varied among the different classes of mutants, suggesting that each was blocked at a distinct step of pilus biogenesis.
(7) At the basis of each pilus, a cell wall differentiation was observed appearing, in face-on-view, as a ring-like structure made up of subunits, and in side-on view as a hollow cylinder penetrating through the cell wall.
(8) Using Western blot analysis of the immunizing pilus and its cyanogen bromide (CNBr) fragments, IgG antibody to pilin was detected before immunization in all individuals.
(9) K99+, 987P+, and type 1 pilus+ bacteria could be prevented from adhering to epithelial cells by Fab fragments specific for K99, 987P, or type 1 pili, respectively.
(10) One recombinant pilus was shown to elicit antibodies against the synthetic peptide in immunized rats.
(11) A purified Gal-Gal pilus vaccine prevented (P less than 0.05) subsequent colonization by a challenge wild-type strain that exhibited homologous pili.
(12) These results showed that trbC function is essential to the F plasmid conjugative transfer system and suggested that the TrbC protein participates in F-pilus assembly.
(13) These observations may indicate a possible evolutionary relationship(s) of plasmids unrelated by the criteria of incompatibility, pilus phage specificity, or plasmid host range.
(14) The presence of an invertible element (Min) is suggested which enables the formation of conjugative pili at 30 degrees C, but switches off the pilus formation at 37 degrees C incubation temperature.
(15) Three classes of pili, alpha, beta and gamma of ascending sub-unit size were identified among the 7 pilus antigen serogroups.
(16) A high titre of pilus antibodies was obtained by immunizing rabbits with mutants whose pili had lost their ability to retract into the cell.
(17) Earlier studies have shown that the majority of Escherichia coli isolates from urinary tract infections which possess a D-mannose-resistant adhesin contain gene sequences homologous to the pap pilus gene sequences encoded on the recombinant plasmid pRHU845.
(18) Like R100, R62 prevented transfer, pilus formation, and surface exclusion and, therefore, probably inhibits expression of the transfer operon traA through traI.
(19) The pilS1 locus contains six tandem pilus gene copies linked by a 39 bp repeat sequence also present in the expression loci.
(20) This mutant no longer produced a 20.5-kDa protein (TcpA) that we show is the major subunit of a V. cholerae pilus.