(1) Perhaps it’s the lot of people like my colleagues here in the centre and me to wrestle with our consciences, shed tears, lose sleep and try to make the best of a very bad, heart-breaking job and leave the rest of the world to party, get pissed and celebrate Christmas.
(2) In the most hard-hitting attack on the Labour leader by any of his MPs since Ukip squeezed the party’s vote in the Heywood and Middleton byelection, Field accused Miliband of “pissing while Rome burns”.
(3) We haven't changed that much, we still take the piss out of each other, there's an understanding there that hasn't gone away.
(4) Brand isn’t the messiah (or just a naughty boy, for that matter) and his message pisses off plenty of people.
(5) Then there's me and my buddy Ralph Garman , who does a daily radio show in LA, doing our entertainment podcast Hollywood Babble-On , which is basically just two guys who've worked in showbiz long enough to have informed opinions, sitting around taking the piss out of the entertainment industry.
(6) Or the story about how Rich was en route from Switzerland to Finland and had to order his jet to reverse course at 20,000ft to avoid being arrested by the FBI at Helsinki airport; or the secret tunnel he built between the 'Dallas building' and the Glashof restaurant opposite so he could slip out to lunch without fear of being assassinated; or the time he was held hostage in Azerbaijan while his captors considered whether or not to sell him to the Russians (who were allegedly pissed off with Rich for nicking their reserves of gold and other precious metals), or the rumours that Rich had slipped in and out of Britain and the US on numerous occasions under false passports.
(7) I haven’t even watched it again because I’m so pissed off about the first one, because I thought Manny could have made that fight much easier than he did.
(8) Of course, after Hitler got into power and Low started, beautifully, to take the piss, Low, along with his cartooning colleagues Illingworth, Vicky and even Heath Robinson, was placed on the Gestapo's deathlist.
(9) The catch is that the wine has been spiked with an extinguished cigarette, bogies, phlegm, piss and maggots; Ryle tackles it with vigour.
(10) Rather than open downstairs and piss off the council, I decided to take it more slowly,” he says.
(11) To my teenage self, who wanted to join Baader-Meinhof and rob banks hand-in-hand with my dead-eyed dream-date Magdalena Kopp, she was the ultimate Hollywood bad girl, always pissing off the right people.
(12) But I know they will complement my weaknesses and help me make better decisions because they will challenge me and, at times, that will piss me off because I want them to think like me and be as excited as me,” he says.
(13) Charly Rexach played for Barcelona between 1965 and 1981 and talks about winning the cup, "their cup", as a way of "really pissing [Real Madrid] off."
(14) The only advantage to being considered insane is, Shields says, that "people don't get as angry with you when you piss them off".
(15) "I sometimes got the feeling that Kurt enjoyed that I pissed people off.
(16) It was written about in the press, and taken the piss out of on other late-night shows.
(17) After the game we shake hands and everything else – what the hell, you’re going to get pissed off?
(18) The only response in these circumstances is to do what the Guardian did – throw your hands up and take the piss .
(19) He said: "The office said she's taking the piss here.
(20) I had phoned up all the national newspapers to say that “something big” was going to happen, and they were a bit pissed off because it wasn’t the dramatic stunt they thought it would be.
Tight
Definition:
() of Tie
() p. p. of Tie.
(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.