(1) Both types of microsphere overcame the initial rapid release of cDDP (burst effect), and PLAGA-coated albumin microspheres also showed a lag phase of approximately 30 min before cDDP release began.
(2) PLAGA-coated albumin microspheres released most of their payload through diffusion, and the coating eventually cracked after 7 days' incubation in saline supplemented with 0.1% Tween at 37 degrees C, enabling the release of any cDDP remaining.
(3) Effects of platinum, pre-released from PLAGA-coated albumin microspheres on the in vitro growth of L1210 cells were comparable with those of standard formulations (dissolved) of cDDP.
(4) Liver-to-kidney platinum level ratios were 28 times higher after 4 h and 19 times higher after 24 h with PLAGA-cDDP microspheres than with free cDDP.
(5) Protein-linked 1-hydroxyethylphosphonate was previously described as the dead-end product after reaction of the analogue with the intermediary acetyl-enzyme form of the catalytic cycle [W. Plaga et al.
(6) PLAGA-cDDP microspheres may, therefore, be a useful and effective addition to current techniques of loco-regional chemotherapy for disseminated hepatic tumors.
(7) These findings indicate a sparing effect on normal tissues when cDDP is targeted to the liver by formulation in PLAGA.
(8) These studies show that formulation of cDDP in PLAGA-based microspheres prevents the rapid burst effect of cDDP seen in previous preparations and offers an improved system of administration for hepatic artery infusion or adjuvant therapy, enabling better clinical handling and the promise of a higher ratio of tumour tissue to normal tissue.
(9) We used a poly-lactide-co-glycolide polymer (PLAGA 50:50) to formulate cisplatin (cDDP) into microspheres designed for intravascular administration.
(10) In a CC531 colon carcinoma liver micrometastases model, cytotoxicity of microsphere-released cDDP was confirmed in vivo by equal inhibition of tumor growth by PLAGA-cDDP and free cDDP over a period of 26 days.
(11) Kidney platinum levels were 7 times lower when PLAGA-cDDP was used.
(12) PLAGA-coated albumin microspheres and microspheres consisting of PLAGA only.
(13) Material released from non-drug-loaded PLAGA microspheres had no effect on L1210 cell growth, suggesting the absence of cytotoxic compounds in the matrix.
(14) Liver-to-blood platinum ratios at these times were 38 times and 36 times higher using PLAGA-cDDP.
Plage
Definition:
(n.) A region; country.
Example Sentences:
(1) The long, curving, sandy Plage des Chevrets is one of the prettiest on Brittany's Emerald Coast.
(2) Paddle on the Riviera Facebook Twitter Pinterest Photograph: Alamy A half-hour walk from the tiny railway station at Cap d’Ail in the Alpes-Maritimes, a coastal footpath runs underneath a line of art nouveau and art deco villas and round a headland before Mala Plage comes into view.
(3) • enjoythecoast.it Plage de Bon Secours, Saint-Malo, France Facebook Twitter Pinterest On calm days, there is a striking contrast between the mirror-like surface of Saint-Malo sea pool and the ruffled sea beyond, between the order of its geometric walls and the random rocky outcrops behind them.
(4) Le Club Farret Vias Plage is on its own exclusive-use beach and with unfancy but functional units clustered in themed areas (pirate has pool, a waterfall and rope bridges; Pacific has a tiki vibe with straw roofs on the cabins).
(5) The first hotel to open in the Landes region is a converted manor house in Mimizan Plage.
(6) • +33 2 98 51 94 94, trimen.fr , hoteldubac.fr , Villa Tri Men doubles from €120 room only, Hotel du Bac from €90 Les Mouettes, Larmor-Plage The restaurant at Les Mouettes comes highly recommended.
(7) While this section of the Seine closes every summer to host the Paris Plages – in which temporary artificial beaches are created along the right bank of the river – this time the expressway has not been reopened.
(8) Thus a cytological study of selectively isolated antigen recognizing cells which form rosettes and antibody producing cells which form hemolytic plages has been performed during oxazolone and lipopolysaccharide stimulations.
(9) South-west of Bordeaux, the Côte d’Argent begins at Mimizan Plage, where a river splits the beach in two.
(10) Our data support the origin of lambda rev plages by recombination between lambda and the Rac prophage following excision of the Rac prophage from the E. coli chromosome.
(11) Facebook Twitter Pinterest A Seine-side holiday: Paris Plages lasts for four weeks during the summer.
(12) Daytrippers stay on Mimizan Plage Sud for surfing, or the riverbank Plage du Courant for swimming.
(13) Before it closed earlier this year for the annual Paris Plage city beach project, 43,000 cars a day passed over the stretch of road.
(14) The campsite has a bar with music nights and a seafood restaurant overlooking the beach, but La Trinité and Carnac-Plage have plenty more family-friendly seafood restaurants and creperies.
(15) This white art deco hotel wouldn't look out of place on Miami's South Beach, but it's on the far less crowded Plage de Locqueltas on Brittany's Morbihan coast.
(16) Huts from €60 a night Le Club Farret Vias Plage, near Béziers, Languedoc Yelloh!
(17) It's a pricey place to eat, though: you may prefer to take the wooden pathway east across the dunes and along the sea wall to Larmor-Plage, a resort with a popular Sunday market and a beachfront promenade of affordable seafood restaurants.
(18) She said the plan involved handing over the right bank of the Seine to pedestrians after the annual Paris Plage festival.
(19) Nor is there the playfulness of Paris Plage , the annual conversion of the banks of the Seine into a beach, or the floating swimming pool that was installed in Copenhagen.
(20) The next entry point is a shady picnic area at Plage de Lespécier, where a plank of wood stuck in the sand announces there’s wifi available.