(1) Both types of microsphere overcame the initial rapid release of cDDP (burst effect), and PLAGA-coated albumin microspheres also showed a lag phase of approximately 30 min before cDDP release began.
(2) PLAGA-coated albumin microspheres released most of their payload through diffusion, and the coating eventually cracked after 7 days' incubation in saline supplemented with 0.1% Tween at 37 degrees C, enabling the release of any cDDP remaining.
(3) Effects of platinum, pre-released from PLAGA-coated albumin microspheres on the in vitro growth of L1210 cells were comparable with those of standard formulations (dissolved) of cDDP.
(4) Liver-to-kidney platinum level ratios were 28 times higher after 4 h and 19 times higher after 24 h with PLAGA-cDDP microspheres than with free cDDP.
(5) Protein-linked 1-hydroxyethylphosphonate was previously described as the dead-end product after reaction of the analogue with the intermediary acetyl-enzyme form of the catalytic cycle [W. Plaga et al.
(6) PLAGA-cDDP microspheres may, therefore, be a useful and effective addition to current techniques of loco-regional chemotherapy for disseminated hepatic tumors.
(7) These findings indicate a sparing effect on normal tissues when cDDP is targeted to the liver by formulation in PLAGA.
(8) These studies show that formulation of cDDP in PLAGA-based microspheres prevents the rapid burst effect of cDDP seen in previous preparations and offers an improved system of administration for hepatic artery infusion or adjuvant therapy, enabling better clinical handling and the promise of a higher ratio of tumour tissue to normal tissue.
(9) We used a poly-lactide-co-glycolide polymer (PLAGA 50:50) to formulate cisplatin (cDDP) into microspheres designed for intravascular administration.
(10) In a CC531 colon carcinoma liver micrometastases model, cytotoxicity of microsphere-released cDDP was confirmed in vivo by equal inhibition of tumor growth by PLAGA-cDDP and free cDDP over a period of 26 days.
(11) Kidney platinum levels were 7 times lower when PLAGA-cDDP was used.
(12) PLAGA-coated albumin microspheres and microspheres consisting of PLAGA only.
(13) Material released from non-drug-loaded PLAGA microspheres had no effect on L1210 cell growth, suggesting the absence of cytotoxic compounds in the matrix.
(14) Liver-to-blood platinum ratios at these times were 38 times and 36 times higher using PLAGA-cDDP.
Playa
Definition:
(n.) A beach; a strand; in the plains and deserts of Texas, New Mexico, and Arizona, a broad, level spot, on which subsequently becomes dry by evaporation.
Example Sentences:
(1) Doubles from €60 B&B Hotel Las Palmas, Carboneras Playa de los Muertos.
(2) Playa Caleta, the main city beach, swings around the bay, a block in front, though modern high-rises cause you to play hide and seek with sea views.
(3) • Doubles from $113 B&B, no phone, ventanasalmarcozumel.com Fusion, Playa del Carmen Facebook Twitter Pinterest Years ago, most of Playa’s hippie beach bars and hostels converted to slicker, louder operations.
(4) Protein variation in 182 Sylvilagus floridanus from 19 playa basins in Castro Co., Texas was examined using starch-gel electrophoresis.
(5) The prospect of retiring to the sunny hills of Provence or the playas of Spain is less attractive since the EU referendum, with older voters concerned their healthcare would no longer be covered post-Brexit, a survey has found.
(6) Named for the whiskered nurse sharks ( gatas ) that once were common in these waters, Playa Las Gatas offers white sand, and spectacular snorkelling.
(7) • Paseo Marítimo Pedregal 17, Playa Pedregal, +34 952 29 15 95, restauranteelcabra.es Bodega Bar El Pimpi El Pimpi is a Málaga institution.
(8) For the less ambitious, there is the spectacular playa Los Muertos , well worth the pleasant 1km amble down a track off the Agua Amarga-Carboneras road.
(9) Two species of hematozoa, Haemoproteus columbae and H. sacharovi, were observed on thin blood smears from populations of mourning doves (Zenaida macroura) in the Rolling Plains (RP, a semiarid dryland farming and grazing area) and Southern High Plains (SHP, an intensively cultivated and irrigated agricultural region with playa lakes) of western Texas (USA).
(10) Here’s Los Parientes de Playa Vicente with La Lloroncita.
(11) Photograph: Lois Pryce I love Bertha’s Café on Playa el Burro .
(12) Visit the Musa underwater sculpture , swim alongside whale sharks or dolphins or simply chill on one of the island’s northern or western beaches, such as wonderful Playa Norte.
(13) Keen123 Playa Las Gatas: a watery Jesus Facebook Twitter Pinterest Photograph: Alamy Playa Las Gatas, three miles south of the Zihuatanejo on the Pacific coast, is accessible only by boat or a treacherous pathway, so getting there always seems like an adventure.
(14) • Dive centres include: isub, San Jose, isubsanjose.com (all year); Buceo Las Negras, buceolasnegras.com (all year); Clear Kayak, Playa San José, clearkayak.es (July-September) WHERE TO EAT Casa Puga, Almería Facebook Twitter Pinterest Casa Puga restaurant.
(15) Twenty larval tiger salamanders (Ambystoma tigrinum) were collected from a playa lake in West Texas and maintained in the laboratory for 7 days prior to the beginning of position training.
(16) He wrote “Playa Escondida” (hidden beach) on a piece of paper and I thought: “I’ve got to go!” I carried that bit of paper with me for ages.
(17) The playlist Facebook Twitter Pinterest A-list playlist for songs from or about Mexico and Central America Willie Nelson and Carlos Santana – They All Went to Mexico Molotov – Frijolero The Four Tops – Loco in Acapulco Los de Abajo – El Loco Chavela Vargas – Vámonos Los Parientes de Playa Vicente – La Lloroncita The Garifuna Collective – Mongulu Café Guancasco – Informe Estadístico de Comienzos de Siglo Peter, Paul and Mary – El Salvador Insane – El Salvador Carlos Mejía Godoy – Nicaragua, Nicaragüita Rubén Blades – Pedro Navaja
(18) A 10-minute drive away is the dramatic, naturist beach Playa de los Muertos.
(19) Hacienda Eden, Playa Troncones, Guerrero The name is not an idle boast: commanding a spot in the middle of gorgeous Manzanillo Bay, 22 miles north of Zihuatanejo, Hacienda Eden’s 10 rooms and four bungalows fill primarily with repeat guests.
(20) Nei's genetic distance between populations ranged from 0.20 to 0.388 and a significant association between genetic distance and linear geographic distance among playas was found.