(1) These facts support that cis-platin was effectively transferred into the cells through Tf-R, when apotransferrin coexisted with cis-platin.
(2) The high response rate obtained is attributed to a synergistic effect of cis-platin and bleomycin administered for prolonged periods.
(3) Km values and competition experiments indicated that the enzyme bound equally well to platinated and unplatinated substrates.
(4) To enhance the efficiency and specificity of diamine methods in light microscopy, these methods were sensitized by silver enhancement in combination with trichloro(ethylene) platinate (KTP).
(5) The majority of 5-year survivors (69%) received cis-platin-containing combination chemotherapy.
(6) The cis-[Pt(NH3)2(d(GpG]] cross-link completely inhibited StuI cleavage, which was fully restored following incubation of the platinated genome with cyanide to remove platinum as [Pt(CN)4]2-.
(7) Cis-platin (DDP) has proved to be highly active in the treatment of ovarian adenocarcinoma.
(8) CHIP and carboplatin gave similar dose-response curves, both being much less toxic than cis-platin.
(9) After selective platination of d(T-C-T-C-G-G-T-C-T-C) (I) at the central d(-GpG-) site (resulting in I-Pt), several non-exchangeable base protons as well as H1', H2', H2" and H3' protons could be assigned by means of conventional NMR double-resonance techniques.
(10) Thirty-three evaluable patients with metastatic breast cancer (12 previously treated with adjuvant chemotherapy) were treated with a combination of cis-platin, doxorubicin, and cyclophosphamide (CAP).
(11) The efficiency of cis Platin (DDP) alone and in combination with Adriamycine (ADM) and Cyclophosphamid (CTX) were evaluated in a prospective randomized trial containing 173 pat.
(12) Skeletal muscle oxygenation was studied by means of a multiwire platin electrode.
(13) Adverse reactions and toxicity often associated with administration of platin were very mild, so that even patients in rather poor physical condition could have been treated.
(14) By serendipity we have had the opportunity to evaluate cis-platin-based chemotherapy in ovarian tumors of low malignant potential (LMP).
(15) We report alternative conformations that may be important in platination of duplex DNA.
(16) Under anaerobic conditions, recombinant pig liver thioltransferase (glutaredoxin)(TT, GRX) (EC 1.8.4.1) was strongly inhibited by cis and carbo-platin and somewhat less sensitive to trans-platin, in vitro.
(17) Normal healthy mice were immunized with cis-platin incubated cells and challenged to check the immunity developed.
(18) Furthermore, the kinetic data indicate that single-step addition reactions are much more impeded at the platinated d(GpG) than at the platinated d(ApG) site and that the mechanisms of inhibition of RNA polymerase activity are different at the two platinated sites.
(19) The platinated plasmids were used as templates for DNA synthesis by the DNA polymerases present in cytosolic extracts prepared from human cell lines HeLa and 293.
(20) The following compounds were investigated: 18-crown-6-tetracarboxybis-diammineplatinum(II) (CTDP), cis-aminotrismethylenephosphonato-diammine-platinum(II) (ADP), cis-diamminecyclohexano-aminotrismethylenephosphonato-platin um(II) (DAP), diethoxybis(1-phenylbutane-1,3-dionato)titanium(IV) (DBT, budotitane), trans-imidazolium-bisimidazoletetrachlororuthenate(III) (ICR), trans-indazolium-tetrachlorobisindazoleruthenate(III) (IndCR), cis-triazolium-tetrachlorobis-triazoleruthenate(III) (TCR) and trans-pyrazolium-tetrachlorobispyrazoleruthenate(III) (PCR).
Platinum
Definition:
(n.) A metallic element, intermediate in value between silver and gold, occurring native or alloyed with other metals, also as the platinum arsenide (sperrylite). It is heavy tin-white metal which is ductile and malleable, but very infusible, and characterized by its resistance to strong chemical reagents. It is used for crucibles, for stills for sulphuric acid, rarely for coin, and in the form of foil and wire for many purposes. Specific gravity 21.5. Atomic weight 194.3. Symbol Pt. Formerly called platina.
Example Sentences:
(1) The results demonstrated that K2PtCl4 was bound to a greater degree than CDDP in this system with 3-5 and 1-2 platinum atoms respectively, bound per transferrin molecule.
(2) • This article was amended on 1 September 2014 because an earlier version described Platinum Property Partners as a buy-to-let mortgage lender.
(3) The potential loss of NH3 in such platinum complexes may lead to additional products over time.
(4) Platinum deer mice are conspicuously pale, with light ears and tail stripe.
(5) The diameters of regenerating crypts were measured at various times after X-rays and cis-platinum given either alone or in combination.
(6) Cis-platinum treatment is considered to be effective and useful for gynecological cancer.
(7) Analyses of mitotic activities and chromosome aberrations in lymphocytes of human peripheral blood have been utilized to evaluate 24-hour cytotoxic and genetic effect of various concentrations (0, 12, 60, 120, 240, 360 mumol l-1) of ethylmalonate platinum (EM-Pt) in vitro.
(8) Excretion into urine within 24 hours was in the range of 54.2% to 92.2% of the administered platinum.
(9) The time dependency of the antitumour activity of (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato++ +)platinum(II) monohydrate (DWA2114R) was examined in mice inoculated i.p.
(10) Primary therapy consisted of surgery, usually unilateral oophorectomy, and cis-platinum-based VAB chemotherapy.
(11) Methods have been reviewed for alkylating agents, platinum compounds, antitumour antibiotics, antimetabolites, alkaloids, suramin, 1-hydroxy-3-amino-propylidene-1,1-bisphosphonate and tamoxifen.
(12) We conclude that the major difference between these two lines was the glutathione-related detoxification of platinum.
(13) In order to determine possible risk factors and to assess the value of platinum microcoils added to polyvinyl alcohol particles in preoperative embolization of cerebral arteriovenous malformations in adults, we reviewed our experience with this procedure.
(14) A mixed platinum (II) complex with tert-butylamine and doxorubicin (coordinated via the amino-group) has been synthesized and tested for antitumor activity.
(15) Unlike cisplatin, bis(platinum) complex binding does not unwind supercoiled DNA.
(16) F-Pt in serum remained more than 90% of total platinum following IP CBDCA until 12 hours after administration.
(17) These data suggest that carrier ligand effects seen in resistant cell lines may be due, in part, to differences in accumulation of platinum, repair of Pt-DNA adducts, and tolerance of Pt-DNA adducts.
(18) To obtain pharmacokinetic data on anticancer drugs, we measured concentrations of plasma and tumor tissue for Cis-platinum, Adriamycin and Bleomycin in operated patients and xenografts.
(19) The effect of various fuel additives on the ability of platinum-palladium catalytic converters to remove the carbon monoxide and hydrocarbon components of automotive exhaust has been examined.
(20) Afferent nerve activity is recorded with a monopolar platinum wire electrode from filaments of the mesenteric nerves that run between the artery and vein supplying the segment.