(n.) That which pricks or pierces; the sharp end of anything, esp. the sharp end of a piercing instrument, as a needle or a pin.
(n.) An instrument which pricks or pierces, as a sort of needle used by engravers, etchers, lace workers, and others; also, a pointed cutting tool, as a stone cutter's point; -- called also pointer.
(n.) Anything which tapers to a sharp, well-defined termination. Specifically: A small promontory or cape; a tract of land extending into the water beyond the common shore line.
(n.) The mark made by the end of a sharp, piercing instrument, as a needle; a prick.
(n.) An indefinitely small space; a mere spot indicated or supposed. Specifically: (Geom.) That which has neither parts nor magnitude; that which has position, but has neither length, breadth, nor thickness, -- sometimes conceived of as the limit of a line; that by the motion of which a line is conceived to be produced.
(n.) An indivisible portion of time; a moment; an instant; hence, the verge.
(n.) A mark of punctuation; a character used to mark the divisions of a composition, or the pauses to be observed in reading, or to point off groups of figures, etc.; a stop, as a comma, a semicolon, and esp. a period; hence, figuratively, an end, or conclusion.
(n.) Whatever serves to mark progress, rank, or relative position, or to indicate a transition from one state or position to another, degree; step; stage; hence, position or condition attained; as, a point of elevation, or of depression; the stock fell off five points; he won by tenpoints.
(n.) That which arrests attention, or indicates qualities or character; a salient feature; a characteristic; a peculiarity; hence, a particular; an item; a detail; as, the good or bad points of a man, a horse, a book, a story, etc.
(n.) Hence, the most prominent or important feature, as of an argument, discourse, etc.; the essential matter; esp., the proposition to be established; as, the point of an anecdote.
(n.) A small matter; a trifle; a least consideration; a punctilio.
(n.) A dot or mark used to designate certain tones or time
(n.) A dot or mark distinguishing or characterizing certain tones or styles; as, points of perfection, of augmentation, etc.; hence, a note; a tune.
(n.) A dot placed at the right hand of a note, to raise its value, or prolong its time, by one half, as to make a whole note equal to three half notes, a half note equal to three quarter notes.
(n.) A fixed conventional place for reference, or zero of reckoning, in the heavens, usually the intersection of two or more great circles of the sphere, and named specifically in each case according to the position intended; as, the equinoctial points; the solstitial points; the nodal points; vertical points, etc. See Equinoctial Nodal.
(n.) One of the several different parts of the escutcheon. See Escutcheon.
(n.) One of the points of the compass (see Points of the compass, below); also, the difference between two points of the compass; as, to fall off a point.
(n.) A short piece of cordage used in reefing sails. See Reef point, under Reef.
(n.) A a string or lace used to tie together certain parts of the dress.
(n.) Lace wrought the needle; as, point de Venise; Brussels point. See Point lace, below.
(n.) A switch.
(n.) An item of private information; a hint; a tip; a pointer.
(n.) A fielder who is stationed on the off side, about twelve or fifteen yards from, and a little in advance of, the batsman.
(n.) The attitude assumed by a pointer dog when he finds game; as, the dog came to a point. See Pointer.
(n.) A standard unit of measure for the size of type bodies, being one twelfth of the thickness of pica type. See Point system of type, under Type.
(n.) A tyne or snag of an antler.
(n.) One of the spaces on a backgammon board.
(n.) A movement executed with the saber or foil; as, tierce point.
(n.) To give a point to; to sharpen; to cut, forge, grind, or file to an acute end; as, to point a dart, or a pencil. Used also figuratively; as, to point a moral.
(n.) To direct toward an abject; to aim; as, to point a gun at a wolf, or a cannon at a fort.
(n.) Hence, to direct the attention or notice of.
(n.) To supply with punctuation marks; to punctuate; as, to point a composition.
(n.) To mark (as Hebrew) with vowel points.
(n.) To give particular prominence to; to designate in a special manner; to indicate, as if by pointing; as, the error was pointed out.
(n.) To indicate or discover by a fixed look, as game.
(n.) To fill up and finish the joints of (a wall), by introducing additional cement or mortar, and bringing it to a smooth surface.
(n.) To cut, as a surface, with a pointed tool.
(v. i.) To direct the point of something, as of a finger, for the purpose of designating an object, and attracting attention to it; -- with at.
(v. i.) To indicate the presence of game by fixed and steady look, as certain hunting dogs do.
(v. i.) To approximate to the surface; to head; -- said of an abscess.
Example Sentences:
(1) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(2) Well tolerated from the clinical and laboratory points of view, it proved remarkably effective.
(3) We are pursuing legal action because there are still so many unanswered questions about the viability of Shenhua’s proposed koala plan and it seems at this point the plan does not guarantee the survival of the estimated 262 koalas currently living where Shenhua wants to put its mine,” said Ranclaud.
(4) She knows you can’t force the opposition to submit to your point of view.
(5) The isoelectric points (pI) of E1 and E2 for all VEE strains studied were approx.
(6) Ofcom will conduct research, such as mystery shopping, to assess the transparency of contractual information given to customers by providers at the point of sale".
(7) Fifty-two pairs of canine femora were tested to failure in four-point bending.
(8) A one point dilution enzyme-linked immunosorbent assay (ELISA) procedure suitable for determining immunoglobulin G (IgG) antibody levels to Toxoplasma gondii (T. gondii) in community seroepidemiological surveys is described.
(9) Subsequent isoelectric focusing in sucrose revealed an isoelectric point of 9.0-9.2.
(10) Gross deformity, point tenderness and decrease in supination and pronation movements of the forearm were the best predictors of bony injury.
(11) Whole-virus vaccines prepared by Merck Sharp and Dohme (West Point, Pa.) and Merrell-National Laboratories (Cincinnati, Ohio) and subunit vaccines prepared by Parke, Davis and Company (Detroit, Mich.) and Wyeth Laboratories (Philadelphia, Pa.) were given intramuscularly in concentrations of 800, 400, or 200 chick cell-agglutinating units per dose.
(12) A Monte Carlo simulation was performed to characterize the spatial and energy distribution of bremsstrahlung radiation from beta point sources important to radioimmunotherapy (RIT).
(13) From the social economic point of view nosocomial infections represent a very important cost factor, which could be reduced to great deal by activities for prevention of nosocomial infection.
(14) He said Germany was Russia’s most important economic partner, and pointed out that 35% of German gas originated in Russia.
(15) Many examples are given to demonstrate the applications of these programs, and special emphasis has been laid on the problem of treating a point in tissue with different doses per fraction on alternate treatment days.
(16) In 11 of the 22 cells PAI-1 mRNA and in 6 of the 22 cells PAI-2 mRNA was found, pointing to a possible role of plasminogen activator inhibitors in the tumor-related plasminogen activator activity.
(17) Sequence specific binding of protein extracts from 13 different yeast species to three oligonucleotide probes and two points mutants derived from Saccharomyces cerevisiae DNA binding proteins were tested using mobility shift assays.
(18) Recent studies point to the involvement of regulatory peptides in diseases of the gut and lung.
(19) The positive predictive accuracy of a biophysical profile score of 0, with mortality and morbidity used as end points, was 100%.
(20) The starting point is the idea that the current system, because it works against biodiversity but fails to increase productivity, is broken.
Terminus
Definition:
(n.) Literally, a boundary; a border; a limit.
(n.) The Roman divinity who presided over boundaries, whose statue was properly a short pillar terminating in the bust of a man, woman, satyr, or the like, but often merely a post or stone stuck in the ground on a boundary line.
(n.) Hence, any post or stone marking a boundary; a term. See Term, 8.
(n.) Either end of a railroad line; also, the station house, or the town or city, at that place.
Example Sentences:
(1) Conditions for limited digestion of the heterodimer by subtilisin, removing only the carboxyl terminus, were determined.
(2) The elongation of helix III with the addition of helix II at the N-terminus somewhat stabilizes the ordered structure.
(3) Synthetic DNA corresponding to the hydrophobic domain of cytochrome b5 was enzymatically fused in-frame to cloned DNA corresponding to the C-terminus of the Escherichia coli enzyme, beta-galactosidase.
(4) TCR beta chain gene expression of individual T cell clones that share the same MHC class II restriction and similar fine specificity for the encephalitogenic NH2 terminus of the autoantigen myelin basic protein (MBP) has been examined.
(5) When these sequences were fused to the N terminus of yeast cytochrome oxidase subunit IV lacking its own presequence, they directed the attached subunit IV to its correct intramitochondrial location in vivo.
(6) Both proteins appeared to be recognized by antibodies against the amino (N) terminus of the alpha 1 subunit sequence.
(7) These plasmin-cleaved peptides are derived from the COOH terminus of C2b, and they induce the contraction of estrous rat uterus.
(8) From the decreased alignment at the N-terminus and the presence of additional residues compared with bacterial phosphorylases, we conclude that the regulatory sequences that also carry the phosphorylation site in the muscle enzyme were joined to a presumed ancestral precursor gene by gene fusion after separation of the eukaryotic and prokaryotic lines of descent.
(9) Microsequencing of the peptides resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicates that the amino terminus of the protein is disposed at or near the cytoplasmic surface of the gap junction, and that this surface also contains a protease-hypersensitive hydrophilic sequence between residues 109 and 123, presumably connecting the second and third transmembrane segments.
(10) The N-terminal sequence (15 amino acid residues) of the L-proline activating fragment obtained by trypsin treatment was identical with that of GS2, indicating that the L-proline activating site is located at the N-terminus of the native synthetase.
(11) It is suggested that a general manner of folding may be a common feature of the heterogeneous population of kappa-chains: one bridge which folds an invariable stretch of the chain, another bridge which folds a stretch that varies from protein to protein, and a bridge at the C-terminus which is the interchain link.
(12) Cysteine proteinase I cleaved peptides primarily from the C-terminal region of Tg, which contained two major hormonogenic sites, while cathepsin-B produced peptides mainly from the N-terminus, containing another major hormonogenic site.
(13) Deletions from the N terminus of LMM did not alter the solubility properties of the expressed material, but deletion of 92 residues from the C terminus caused a large increase in solubility at low ionic strength, indicating that a determinant important for interaction between LMM molecules was located in this region.
(14) Middle component particles of bean pod mottle virus (BPMV) containing small protein subunits with a cleaved C terminus were used to produce monoclonal antibodies (MAbs).
(15) We find that the NH2-terminus of PTH is rapidly degraded in situ by the liver but that both liver and especially kidney nevertheless contain low levels of NH2-terminal PTH fragments that, although not released into the blood, are large enough to be potentially active.
(16) 2) By contrast, the COOH terminus is an inhibitory regulator of mitogenesis, and removal of the terminal 43 amino acids converts the receptor from a moderately active growth signaler to a very active one.
(17) Since the HPV-16 E6-promoted degradation involves the ubiquitin-dependent proteolysis pathway, specific mutations were made in the amino terminus of p53 to examine whether the E6 targeted degradation involved the N-end rule pathway.
(18) Examination of the inhibitory effect of ATP using oligo(dA)12-18 as well as activated DNA as primers revealed that (a) ATP inhibition is not due to its addition onto a 3'-OH primer terminus ad judged by the lack of incorporation of labeled ATP, although under similar conditions incorporation of GTP can be demonstrated, (b) a consistent degree of inhibition was noted independent of primer or enzyme concentration; (c) addition of ATP to an ongoing reaction promptly reduces the rate of polymerization; (d) kinetic studies indicate a competitive (with respect to substrate deoxy triphosphate) pattern of inhibition; (e) addition of excess deoxyribotriphosphate promptly relieves the inhibition.
(19) A peptide corresponding to the COOH terminus (residues 45-65) was synthesized utilizing lysine 47 as a specific residue to conjugate to thyroglobulin as a carrier for raising antibodies in mice.
(20) Myristic acid-labeled virions contained a single radioactive protein, p10, supporting the mapping of this molecule to the amino terminus.