What's the difference between poison and tolerance?

Poison


Definition:

  • (n.) Any agent which, when introduced into the animal organism, is capable of producing a morbid, noxious, or deadly effect upon it; as, morphine is a deadly poison; the poison of pestilential diseases.
  • (n.) That which taints or destroys moral purity or health; as, the poison of evil example; the poison of sin.
  • (n.) To put poison upon or into; to infect with poison; as, to poison an arrow; to poison food or drink.
  • (n.) To injure or kill by poison; to administer poison to.
  • (n.) To taint; to corrupt; to vitiate; as, vice poisons happiness; slander poisoned his mind.
  • (v. i.) To act as, or convey, a poison.

Example Sentences:

  • (1) Resistance to antibiotics have been detected in food poisoning bacteria, namely Salmonella typhimurium, Staphylococcus aureus and Clostridium perfringens.
  • (2) It can induce acute cholinesterase poisoning, which is rapidly reversible on discontinuation of exposure.
  • (3) There is a disparity between the number of reported cases of poisoning and the number of chemical analyses performed for the identification and quantitative determination of a particular poison.
  • (4) A case is presented of deliberate chewing of the flowers of henbane (Hyoscyamus niger) in the hope of producing euphoria, and an account is given of the poisoning so produced.
  • (5) "Our black, Muslim and Jewish citizens will sleep much less easily now the BBC has legitimised the BNP by treating its racist poison as the views of just another mainstream political party when it is so uniquely evil and dangerous."
  • (6) Extrapyramidal syndromes after ischemic anoxia are rare, when compared to their relative frequency after carbon monoxide poisoning.
  • (7) Concern about the safety of the patient and dental personnel does exist, however, due to the possibilities of mercury poisoning.
  • (8) Excess levels of selenium (2.5 and 5 ppm) in the vitamin E-deficient diet had little or no effect on spleen size or hematocrit of rats not receiving lead, but partially prevented the splenomegaly and anemia of red cells from either non-poisoned or lead-oisoned vitamin E-deficient rats, but not as effectively as vitamin E. These results show that vitamin E status of rats is more important that selenium status in determining response to toxic levels of lead.
  • (9) Toxicity has been reported in the fetus of a woman ingesting a huge overdose of digitoxin; the same result would be anticipated with digoxin poisoning.
  • (10) Three esterase inhibitors, phenylmethylsulfonyl fluoride, bis-(p-nitrophenyl)-phosphate, and diisopropylfluorophosphate, had no effect on the antidote effectiveness of N-acetylcysteine, although each provided partial protection against acetaminophen poisoning.
  • (11) The deaths were due to: hanging (41 cases), poisoning (17 cases), leaping from a height (7 cases), and others (11 cases including one case of self shooting).
  • (12) In vivo the administration of captopril prevented the toxic effects of mercury poisoning on membrane permeability, oxidative phosphorylation and Ca++ homeostasis.
  • (13) Large doses of dsFab are efficacious in the treatment of dysrhythmias in this canine model of N oleander cardiac glycoside poisoning.
  • (14) A recent report indicated that an arrow poison used by the native Indians of Rondonia, Brazil, to kill small animals was associated with profuse bleeding.
  • (15) When Hayley Cropper swallows poison on Coronation Street on Monday night, taking her own life to escape inoperable pancreatic cancer, with her beloved husband, Roy, in pieces at her bedside, it will be the end of a character who, thanks to Hesmondhalgh's performance, has captivated and challenged British TV viewers for 16 years.
  • (16) Zelaya's food comes separately and is prepared by his daughter because he fears being poisoned.
  • (17) Characteristics of the poisoning include a delay between exposure and onset of symptoms; early systemic toxicity with congestive changes in the lungs and oliguric renal failure; prominent cerebellar and Parkinsonian neurologic symptoms as well as seizures and coma in severe cases; and psychiatric disturbances that can last from months to years.
  • (18) A method of poisoning cats with thallium is described.
  • (19) They were given individually to guinea pigs prior to poisoning with 2 x LD50 soman to test their efficacy against organophosphorus-induced convulsions, brain damage, and lethality.
  • (20) This incident prompted the poison center to evaluate our emergency response capabilities.

Tolerance


Definition:

  • (n.) The power or capacity of enduring; the act of enduring; endurance.
  • (n.) The endurance of the presence or actions of objectionable persons, or of the expression of offensive opinions; toleration.
  • (n.) The power possessed or acquired by some persons of bearing doses of medicine which in ordinary cases would prove injurious or fatal.

Example Sentences:

  • (1) within 12 h of birth followed by similar injections every day for 10 consecutive days and then every second day for a further 8 weeks, with mycoplasma broth medium (tolerogen), to induce immune tolerance.
  • (2) No differences between the two substances were observed with respect to side effects and general tolerability.
  • (3) This treatment is usually well tolerated but not devoid of systemic effects.
  • (4) Well tolerated from the clinical and laboratory points of view, it proved remarkably effective.
  • (5) To estimate the age of onset of these differences, and to assess their relationship to abdominal and gluteal adipocyte size, we measured adiposity, adipocyte size, and glucose and insulin concentrations during a glucose tolerance test in lean (less than 20% body fat), prepubertal children from each race.
  • (6) Although temazepam was effective for maintaining sleep with short-term use, there was rapid development of tolerance for this effect with intermediate-term use.
  • (7) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
  • (8) There were no biochemical or haematological abnormalities caused by prazosin but on continued therapy 16 patients developed tolerance to its effect.
  • (9) Characerization of further parameters such as relative susceptibility to tolerance induction and relative degree of specificity was not possible with the use of KLH as the antigen.
  • (10) Because of these different direct and indirect actions, a sudden cessation of sinus node activity or sudden AV block may result in the diseased heart in a prolonged and even fatal cardiac standstill, especially if the tolerance to ischemia of other organs (notably the brain) is decreased.
  • (11) Efficacy and tolerability of perorally administered desmopressin were evaluated in 12 adult patients suffering from central diabetes insipidus.
  • (12) This suggests that both blood transfusion and allograft are required for IL2 suppression and that this suppression may be related to the heart tolerance.
  • (13) At present, ACE inhibitors are preferred because they are usually better tolerated than conventional vasodilators and are clinically more effective.
  • (14) Changes in pain tolerance after administration of differently labelled placebos were studied by measuring the reaction time after a cold stimulus.
  • (15) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
  • (16) Provided that adequate reflection is given and the appropriate moment chosen, it is well tolerated and provides all the necessary information.
  • (17) After large bowel removal, there was impaired glucose tolerance and attenuated plasma insulin secretion.
  • (18) Cardiac pump function is not affected, even in patients with ventricular dysfunction or heart failure, in whom chronic oral administration of the drug is well tolerated.
  • (19) These agents have been well-tolerated and generally produce a high incidence of sustained improvements in neutrophil counts and marrow morphology, although hemoglobin and platelet counts have generally not been altered.
  • (20) The above treatment is tolerated well and no serious side effects have been observed.