(1) On the basis of genetic, phenotypic and physiological criteria, these mutants are divided into four groups: 1) the cytochrome aa3 and b deficient "poky" variants that are defective in mitochondrial ribosomes assembly, 2) the cytochrome aa3 deficient mutants, [mi-3] and [exn-5], that appear to have genetic lesions affecting a component of a regulatory system controlling cytochrome aa3 synthesis, 3) the cytochrome aa3 and b deficient "stopper" mutants with physiological lesions that probably affect mitochondrial protein synthesis, and 4) cni-3, a mutant that is constitutive for an inducible mitochondrial cyanide-insensitive oxidase in spite of having a normal cytochrome mediated electron-transport system.
(2) Cell respiration in wild type and poky was studied as part of a long-term investigation of cyanide-resistant respiration in Neurospora.
(3) Six independently isolated Group 1 extranuclear mutants, namely [exn-1], [exn-2], [exn-4-a1, [stp-b1], [SG-1] and [SG-3-A1, which have growth and cytochrome phenotypes similar to [poky] also were found to be deficient in small subunits of mitochondrial ribosomes.
(4) Seven nonallelic nuclear suppressors of [poky] result in increased concentrations of the mt small rRNA and pre-rRNAs, but do not restore the ability to synthesize small rRNAs having the correct 5' ends.
(5) Group I consists of 8 female-fertile variants with both poky-like growth and cytochrome defects.
(6) Two-dimensional gel electrophoresis was used to examine mit ribosomal proteins from [poky] and six additional extra-nuclear mutants with defects in the assembly of mit small subunits.
(7) Six nuclear suppressors of the (poky) cytoplasmic mutant (sup-1, sup-3, sup-4, sup-5, sup-10, sup-14) have been obtained in Neurospora crassa.
(8) However, the transmission of the [poky] mutation does not appear to be correlated with the transmission of either of these insertions or of other physical markers.
(9) Mitochondria from the cytochrome-deficient mutant poky carried out substrate-driven K+ uptake at reduced rates, but oligomycin-sensitive, ATP-driven K+ uptake at rates about 60% greater than those shown by wild-type mitochondria.
(10) But actually Chote's team is only about 20-strong and they operate from a rather poky office on Victoria Street.
(11) We have compared the adenosine triphosphatase (ATPase) activity of mitochondria prepared from wild-type Neurospora crassa and from poky, a maternally inherited mutant known to possess defective mitochondrial ribosomes and reduced amounts of cytochromes aa3 and b. poky contains two distinct forms of mitochondrial ATPase.
(12) Pokie Nation, set to air next week on the ABC, has been edited to amend the claim.
(13) In all these experiments, no difference was detected between wild type and poky in base sequence or methylation of either 19 S or 25 S RNA.
(14) The six suppressors are nonallelic, suppress the phenotypic effects of (stp-Bl) in addition to (poky), but have no effect on the phenotype expression of the (mi-3) cytoplasmic mutant.
(15) An analysis of the paramagnetic components present in mitochondria isolated from the poky mutant of Neurospora crassa is described.
(16) Orta filmed the death of Eric Garner , capturing the moment the 43-year-old was placed in a banned chokehold by an NYPD officer and uttered his last words: “I can’t breathe.” Lawyers Ken Perry and William Aronin sit in the poky downtown Manhattan apartment that serves as their office.
(17) The mitochondrial phenotype of [poky] and other extranuclear Neurospora mutants is known to predominate over that of wild type in heteroplasmons.
(18) They are not allowed to draw in court, so they must observe, make notes about someone’s characteristics and clothes, and then retreat to a poky press room where they sketch and colour at high speed.
(19) The residual small rRNAs in [poky] appear to be synthesized via the upstream promoter(s), but are missing 37-44 nucleotides from their 5' ends, indicating either that pre-rRNAs are processed abnormally or that abnormal 5' RNA ends are unstable.
(20) The ribosomal defect shows an extrachromosomal pattern of inheritance in crosses of poky with wild type.
Pony
Definition:
(n.) A small horse.
(n.) Twenty-five pounds sterling.
(n.) A translation or a key used to avoid study in getting lessons; a crib.
(n.) A small glass of beer.
Example Sentences:
(1) The compromised ice sheet tilts and he sinks into the Arctic Sea on the back of his faltering white Icelandic pony.
(2) "We see him driving around, but he keeps to himself and we're quite close neighbours," said Libbi Darroch, as she groomed her 7-year-old showjumper Muffy at the Coatesville pony club.
(3) In a further study, three ponies treated on separate occasions with lincomycin, administered orally, died or were destroyed 67 to 72 h after initial treatment.
(4) Principal ponies had a history of heaves, a disease characterized by recurrent airway obstruction.
(5) Nine Przewalski's horse embryos were transferred surgically, and 2 non-surgically, to domestic Welsh-type pony mares.
(6) The erythrogram (erythrocyte histogram) and red cell distribution width (RDW) were evaluated in 5 purebred horses and 1 pony of mixed breeding with experimentally induced anemia.
(7) Pulmonary function measurements were made in control ponies and in ponies with recurrent obstructive pulmonary disease (principals) during clinical remission and during an attack of acute airway obstruction.
(8) The Campbell family has been breeding ponies in Glenshiel for more than 100 years and now runs a small pony trekking centre offering one-hour treks along the pebbly shores of Loch Duich and through the Ratagan forest as well as all-day trail rides up into the hills for the more adventurous.
(9) However, large colon resection was associated with hypophosphatemia in three of the six ponies and produced an overall significantly lower phosphate concentration in the experimental ponies.
(10) A pony-tailed local businessman, Hall rose to prominence during the referendum campaign when he used a reconditioned Green Goddess fire engine to distribute pro-independence literature.
(11) A critical trial was performed with five ponies 6-9 months of age and raised on a horse farm with demonstrated benzimidazole-resistant cyathostomes.
(12) A second group of 5 ponies was fed a ration at varying rates containing 8 ppm FB1 for 180 days.
(13) Significantly (P less than 0.02) higher mean total numbers of P equorum were found in the small intestinal contents of the controls on day 14 (51) and on day 35 (21) than in the ivermectin-treated ponies on days 14 (0) and 35 (3).
(14) The prevalence of Anoplocephala perfoliata in 103 horses and ponies from Clwyd, Powys and the adjacent English marches, slaughtered during January 1987, was 69 per cent.
(15) The hindlimbs of 3 ponies and 3 horses were dissected.
(16) The results were compared to two control ponies and four others infected by accidental transmission.
(17) Further evidence that reinnervation occurred in the larynges of these ponies was determined in microscopic sections of the recurrent laryngeal nerves and muscles, which showed regenerative activity and muscle fiber-type grouping, respectively.
(18) Larvae of D arnfieldi were found in fecal samples of 112 (2%) of 5,379 horses on the 90 farms of which 38% had greater than or equal to 1 infected animal; none of 19 ponies examined was infected.
(19) A paste formulation containing 14.3 per cent of oxibendazole and 44 per cent of trichlorfon was administered to 33 ponies and horses.
(20) Ponies given PBZ and prostaglandin E2 remained clinically healthy and did not develop hypoproteinemia or mucosal atrophy.