(1) On the basis of genetic, phenotypic and physiological criteria, these mutants are divided into four groups: 1) the cytochrome aa3 and b deficient "poky" variants that are defective in mitochondrial ribosomes assembly, 2) the cytochrome aa3 deficient mutants, [mi-3] and [exn-5], that appear to have genetic lesions affecting a component of a regulatory system controlling cytochrome aa3 synthesis, 3) the cytochrome aa3 and b deficient "stopper" mutants with physiological lesions that probably affect mitochondrial protein synthesis, and 4) cni-3, a mutant that is constitutive for an inducible mitochondrial cyanide-insensitive oxidase in spite of having a normal cytochrome mediated electron-transport system.
(2) Cell respiration in wild type and poky was studied as part of a long-term investigation of cyanide-resistant respiration in Neurospora.
(3) Six independently isolated Group 1 extranuclear mutants, namely [exn-1], [exn-2], [exn-4-a1, [stp-b1], [SG-1] and [SG-3-A1, which have growth and cytochrome phenotypes similar to [poky] also were found to be deficient in small subunits of mitochondrial ribosomes.
(4) Seven nonallelic nuclear suppressors of [poky] result in increased concentrations of the mt small rRNA and pre-rRNAs, but do not restore the ability to synthesize small rRNAs having the correct 5' ends.
(5) Group I consists of 8 female-fertile variants with both poky-like growth and cytochrome defects.
(6) Two-dimensional gel electrophoresis was used to examine mit ribosomal proteins from [poky] and six additional extra-nuclear mutants with defects in the assembly of mit small subunits.
(7) Six nuclear suppressors of the (poky) cytoplasmic mutant (sup-1, sup-3, sup-4, sup-5, sup-10, sup-14) have been obtained in Neurospora crassa.
(8) However, the transmission of the [poky] mutation does not appear to be correlated with the transmission of either of these insertions or of other physical markers.
(9) Mitochondria from the cytochrome-deficient mutant poky carried out substrate-driven K+ uptake at reduced rates, but oligomycin-sensitive, ATP-driven K+ uptake at rates about 60% greater than those shown by wild-type mitochondria.
(10) But actually Chote's team is only about 20-strong and they operate from a rather poky office on Victoria Street.
(11) We have compared the adenosine triphosphatase (ATPase) activity of mitochondria prepared from wild-type Neurospora crassa and from poky, a maternally inherited mutant known to possess defective mitochondrial ribosomes and reduced amounts of cytochromes aa3 and b. poky contains two distinct forms of mitochondrial ATPase.
(12) Pokie Nation, set to air next week on the ABC, has been edited to amend the claim.
(13) In all these experiments, no difference was detected between wild type and poky in base sequence or methylation of either 19 S or 25 S RNA.
(14) The six suppressors are nonallelic, suppress the phenotypic effects of (stp-Bl) in addition to (poky), but have no effect on the phenotype expression of the (mi-3) cytoplasmic mutant.
(15) An analysis of the paramagnetic components present in mitochondria isolated from the poky mutant of Neurospora crassa is described.
(16) Orta filmed the death of Eric Garner , capturing the moment the 43-year-old was placed in a banned chokehold by an NYPD officer and uttered his last words: “I can’t breathe.” Lawyers Ken Perry and William Aronin sit in the poky downtown Manhattan apartment that serves as their office.
(17) The mitochondrial phenotype of [poky] and other extranuclear Neurospora mutants is known to predominate over that of wild type in heteroplasmons.
(18) They are not allowed to draw in court, so they must observe, make notes about someone’s characteristics and clothes, and then retreat to a poky press room where they sketch and colour at high speed.
(19) The residual small rRNAs in [poky] appear to be synthesized via the upstream promoter(s), but are missing 37-44 nucleotides from their 5' ends, indicating either that pre-rRNAs are processed abnormally or that abnormal 5' RNA ends are unstable.
(20) The ribosomal defect shows an extrachromosomal pattern of inheritance in crosses of poky with wild type.
Small
Definition:
(superl.) Having little size, compared with other things of the same kind; little in quantity or degree; diminutive; not large or extended in dimension; not great; not much; inconsiderable; as, a small man; a small river.
(superl.) Being of slight consequence; feeble in influence or importance; unimportant; trivial; insignificant; as, a small fault; a small business.
(superl.) Envincing little worth or ability; not large-minded; -- sometimes, in reproach, paltry; mean.
(superl.) Not prolonged in duration; not extended in time; short; as, after a small space.
(superl.) Weak; slender; fine; gentle; soft; not loud.
(adv.) In or to small extent, quantity, or degree; little; slightly.
(adv.) Not loudly; faintly; timidly.
(n.) The small or slender part of a thing; as, the small of the leg or of the back.
(n.) Smallclothes.
(n.) Same as Little go. See under Little, a.
(v. t.) To make little or less.
Example Sentences:
(1) The effect of insulin-like growth factor I (IGF-I) on growth of small cell lung cancer (SCLC) cell lines was studied.
(2) Such a signal must be due to a small ferromagnetic crystal formed when the nerve is subjected to pressure, such as that due to mechanical injury.
(3) The Na+ ionophore, gramicidin, had a small but significant inhibitory effect on Na(+)-dependent KG uptake, demonstrating that KG uptake was not the result of an intravesicular positive Na+ diffusion potential.
(4) For some time now, public opinion polls have revealed Americans' strong preference to live in comparatively small cities, towns, and rural areas rather than in large cities.
(5) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(6) If Charles Spencer, 3rd Duke of Marlborough, who bought the island in 1738, were to return today he would doubtless recognise the scene, though he might be surprised that his small private buildings have grown into a sizable hotel.
(7) We conclude that chronic emphysema produced in dogs by aerosol administration of papain results in elevated pulmonary artery pressure, which is characterized pathologically by medial hypertrophy of small pulmonary arteries.
(8) As the percentage of rabbit feed is very small compared to the bulk of animal feeds, there is a fair chance that rabbit feed will be contaminated with constituents (additives) of batches previously prepared for other animals.
(9) The extent of the infectious process was limited, however, because the life span of the cultures was not significantly shortened, the yields of infectious virus per immunofluorescent cell were at all times low, and most infected cells contained only a few well-delineated small masses of antigen, suggestive of an abortive infection.
(10) The small units described here could be inhibitory interneurons which convert the excitatory response of large units into inhibition.
(11) Early stabilisation may not ensure normal development but even early splinting carries a small risk of avascular necrosis.
(12) Twenty patients with non-small cell bronchogenic carcinoma were prospectively studied for intrathoracic lymphadenopathy using computed tomography (CT) and magnetic resonance imaging (MRI).
(13) In addition, KM231 could detect a small amount of the antigen ganglioside in human gastric normal and cancerous mucosa and in gastric cancer cell lines by HPTLC-immunostaining.
(14) Two small populations of GLY + neurons were observed outside of the named nuclei of the SOC; one was located dorsal to the LSO, near its dorsal hilus, and the other was identified near the medial pole of the LSO.
(15) Because of the small number of patients reported in the world literature and lack of controlled studies, the treatment of small cell carcinoma of the larynx remains controversial; this retrospective analysis suggests that combination chemotherapy plus radiation offers the best chance for cure.
(16) Only small amounts of 3H oleic acid were converted.
(17) The pH gradient measured with dimethyloxazolidine-2,4-dione and acetylsalicylic acid was very small in both bacteria at a high pH above 8, and was not affected significantly by the addition of CCCP.
(18) The results also indicate that small lesions initially noted only on CT scans of the chest in children with Wilms' tumor frequently represent metastatic tumor.
(19) CT scan revealed a small calcified mass in the right maxillary sinus.
(20) We have previously shown that intratracheally instilled silica (quartz) produces both morphologic evidence of emphysema and small-airway changes, and functional evidence of airflow obstruction.