What's the difference between polyacid and polybasic?
Polyacid
Definition:
(a.) Capable of neutralizing, or of combining with, several molecules of a monobasic acid; having more than one hydrogen atom capable of being replaced by acid radicals; -- said of certain bases; as, calcium hydrate and glycerin are polyacid bases.
Example Sentences:
(1) A polyacidic amino acid stretch immediately adjacent to the SRF homologous domain of MCM1 was found to be important for activation of alpha-specific genes in alpha cells.
(2) It was found that high adsorption levels were achieved under conditions of high chain entanglement, such as in a concentrated solution of a polyacid of high RMM.
(3) The C-terminal region of the protein contains the established pattern of polyacidic clusters, common to calreticulins of other species and ends in the ER retention signal HDEL.
(4) We show that this polyacidic sequence appends to RAD6 protein as a polyanionic tail and that its function in vivo does not require stoichiometry of length.
(5) For example, our analysis has identified a conserved polyacidic stretch in all three phosphoproteins which we propose mediates metal binding.
(6) The 24-h DTS values of the HEMA composites (14-26 MPa) were higher than those of the polyacid cements (7-12 MPa).
(7) Strains with deletions of all but the first 4 or 15 residues of the polyacidic sequence were phenotypically almost wild type or wild type, respectively.
(8) We conclude that the intrinsic activity of RAD6 protein resides in the globular domain, that the polyacidic sequence has a stimulatory or modifying role evident primarily in sporulation, and that only a short section apparently functions as effectively as the entire polyacidic sequence.
(9) The various dyes displayed considerable variability in the ease with which they could be displaced from substrates with polyacid solutions during the differentiation step.
(10) Glass-ionomer cements are the reaction product of an aluminosilicate glass and a polyacid, for example poly (acrylic acid).
(11) The N-terminal region, of approximately neutral net charge and hydrophobicity, is followed by a central proline-rich zone with repeat sequences separated from the polyacidic C-terminal stretch by a short hydrophobic sequence.
(12) The subcellular localization and physicochemical properties of prothymosin alpha suggest that its function is related to those of other long polyacidic regions containing nuclear proteins.
(13) Removal of the entire polyacidic sequence severely reduced sporulation but only slightly affected survival after UV irradiation or UV-induced mutagenesis.
(14) Flexural strength was also found to be increased by increasing the molecular weight of the polyacid.
(15) Interactions of proteins with neutral polysaccharides and such polyacids as polygalacturonic acid, chondroitin sulphate, RNA and DNA in a two-phase system composed of phenol and aqueous buffers in the pH range 1.5-10 were studied.
(16) We conclude that this tyrosine kinase is reversibly bound to the membrane through electrostatic interactions with the polyacidic sequence surrounding the phosphate accepting tyrosine 8 on band 3.
(17) Pf16 is highly basic, contains a polyacidic domain consisting of aspartic acid and is related to the non-histone high mobility group proteins of higher eukaryotes.
(18) The carboxyl-terminal polyacidic sequence was sensitive to proteinase K, and it endowed RAD6 protein with an aberrantly large Stokes radius that indicates an asymmetric shape.
(19) Our experiments show that deletion of varying lengths of the polyacidic tail of RAD6 protein greatly reduces its ubiquitin-conjugating activity.
(20) The polyacids, on the other hand, in the absence of interactions were recovered mainly from the aqueous phases.
Polybasic
Definition:
(a.) Capable of neutralizing, or of combining with, several molecules of a monacid base; having several hydrogen atoms capable of being replaced by basic radicals; -- said of certain acids; as, sulphuric acid is polybasic.
Example Sentences:
(1) The polypeptide does not, however, have a deswelling effect on the tissue; the ultimate reduction in swelling is influenced by the absolute amount of polybase which enters the tissue during the swelling process.
(2) Only casein kinase-2 and a spleen tyrosine protein kinase (TPK-III) proved effective, their phosphorylation efficiency being dramatically enhanced by histones and other polybasic peptides while being depressed by 50 microM Ca2+.
(3) Within the hypervariable domain of p21K-ras(B), which is not palmitoylated, we have identified a novel plasma membrane targeting signal consisting of a polybasic domain that also acts in combination with the CAAX motif.
(4) The polybasic acids trypan blue and its analogue trypan red, bromphenol blue and its analogue bromthymol blue at concentrations of 0.22 mM and ethylenediaminetetra-acetic acid (EDTA) at a concentration of 1 mM are strong inhibitors of the enzyme.3.
(5) Mutational analysis of p21ras has shown that plasma membrane targeting requires the combination of a CAAX motif with a polybasic domain of six lysine residues or a nearby palmitoylation site.
(6) A method for the isolation of vacuoles based on polybase induced lysis of protoplasts of the cell wall deficient Neurospora crassa slime variant is described.
(7) Plasma membrane targeting of p21K-ras(B) requires a CAAX motif and a polybasic domain.
(8) The swelling kinetics of polybasic gels consisting of copolymers of methyl methacrylate and dimethylaminoethyl methacrylate are studied in solutions at various acidic pH values, with monoacidic derivatives of acetic acid added as buffers.
(9) Polybasic acids affording insoluble salts were evaluated for their ability to form drug:acid:metal complexes with the polyvalent metal ions, Zn++, Al+++, Mg++ and Ca++.
(10) Modification of BHV tissue was obtained by covalently binding protamine sulfate, a polybasic peptide, via glutaraldehyde.
(11) Potassium chloride in high concentrations and calcium chloride in low concentrations inhibited polybase induced lysis of spheroplasts by preventing or even reversing the polybase adsorption.
(12) Profilin with one covalently attached actin CNBr peptide was purified by gel filtration followed by gel electrophoresis and electroblotting on polybase-coated glass-fiber membranes.
(13) Modification of BHV tissue was obtained by covalently binding protamine sulfate, a polybasic peptide, via formaldehyde and subsequent glutaraldehyde tissue crosslinking.
(14) With labeled proteins used as models, it is found that the transport proceeds at very low rates, requires little energy, and is markedly enhanced by polybasic compounds.
(15) The polybasic macromolecules DEAE-dextran (diethylaminoethyl-dextran, molecular weight 500000) and poly-DL-lysine (molecular weight 30000-70000) were absorbed with a high affinity by spheroplasts of Candida utilis and subsequently, induced lysis.
(16) The differences in accumulation levels of Mn2+ and Sr2+ attained after prolonged incubation are completely abolished in cells of which the plasmamembrane has been permeabilized with the polybase DEAE-dextran under isotonic conditions.
(17) Adsorption of polybases was rapidly completed even at 0 degrees C; however, with small doses, lysis was poor at 0-12 degrees C and extensive at temperatures above 12 degrees C. This permitted the completion of adsorption before initiating lysis.
(18) The results indicate that the phosphorylated form of PGKARKKSSC-geranylgeranyl stoichiometrically interacts with smg p21 GDS, that the presence of the geranylgeranyl moiety is essential for, but not sufficient for, the smg p21 GDS action, and that the presence of the methyl moiety, removal of the three C-terminal amino acids, and the presence of the polybasic amino acids also affect the smg p21 GDS action.
(19) Vacuoles isolated from polybase lysed spheroplasts still contained large pools of soluble amino acids, and their ability to transport arginine specifically is a further indication of their functional integrity.
(20) It is proposed that the cationic C3a molecule activates rat mast cells in a secretory and nonlytic manner by a nonspecific mechanism similar to that of other polybasic compounds.