What's the difference between potency and purity?

Potency


Definition:

  • (n.) The quality or state of being potent; physical or moral power; inherent strength; energy; ability to effect a purpose; capability; efficacy; influence.

Example Sentences:

  • (1) A total of 104 evaluable patients 20-90 years old treated by direct vision internal urethrotomy a.m. Sachse for urethral strictures reported retrospectively via a questionnaire their sexual potency before and after internal urethrotomy.
  • (2) Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency.
  • (3) The relative potencies compared to insulin-like growth factor 2 (IGF-2) in displacing [125I]IGF-2 from rat liver membranes were recombinant truncated IGF-1, 0.3% and recombinant IGF-1, 0.2%.
  • (4) Thus, introduction of arginine in position 5 with a hydrophobic amino acid in position 6 is compatible with high potency in several biological systems and results in compounds with lowered potency to release histamine compared to homologous peptides with tyrosine in position 5 and D-arginine in position 6.
  • (5) Significant differences in the pharmacological characteristics of the alpha 2 adrenoceptor were observed between the tissues with reference to both absolute drug affinities as well as rank order of drug potency.
  • (6) We investigated the in vivo phospholipidosis-inducing potency of AM and its major nonpolar metabolite, desethylamiodarone (DEA), in rats, their ability to inhibit phospholipases, and also the effects on pulmonary uptake of [14C] AM.
  • (7) This activity scheme uses as its base, dose potency measured as TD50, the chronic dose rate that actuarially halves the adjusted percentage of tumor-free animals at the end of the study (Gold et al., Environ.
  • (8) Neuropeptides increased the labeling of p115 within seconds and with great potency; half-maximum concentrations were 0.1, 0.2 and 0.3 nM for bombesin, vasopressin, and VIC, respectively.
  • (9) The rank order of potency of the peptides tested was VIP greater than rat (r) peptide histidine isoleucine = human (h) PHI greater than rGRF greater than bovine GRF = porcine PHI = VIP-(10-28) greater than hGRF greater than secretin greater than apamin greater than glucagon.
  • (10) Unlabeled IGF-I displaced both the IGF-I and insulin bindings with potencies that were 100 and 10 times as great as insulin.
  • (11) Displacing potencies for dopamine in the nanomolar range are associated with agonist-specific D-3 receptor binding and it is predicted that the component of D-2 binding with high agonist affinity may play a confounding role in many D-3 receptor studies.
  • (12) Menses resumed in all 6 women 7 to 41 days after the injection, galactorrhea disappeared in all 4 patients, and libido and potency become normal in both men with microprolactinomas.
  • (13) A hybrid analog cecropin A-(1-11) D-(12-37) was designed and predicted to have enhanced potency.
  • (14) On guinea-pig lung strip the rank order of potency was U-46619 greater than Wy17186 much greater than PGF2 alpha greater than PGE2 and responses to all agonists tested were blocked by AH19437 but not by SC-19220.
  • (15) Quantitatively, however, there was not a good correlation between liver DNA alkylation and the potency of the nitrosamine in inducing tumors.
  • (16) On the other hand, SM-3997 and buspirone exhibited dopamine antagonistic action, although the potency of SM-3997 was less than one fourth that of buspirone.
  • (17) The wide variation in potency explains the variation found in absolute bioavailability, and the increase in release rate when the pellets are crushed explains the differences seen in peak plasma times, since the pellets will be chewed to varying degrees by the horse.
  • (18) Comparing IC50 values of EGCG and aspirin it was found that the potency of EGCG is comparable to that of aspirin.
  • (19) Hyperprolactinemia, hypogonadotropinism, and subnormal plasma testosterone were found in a 65-year-old patient who had an enlarged sella turcica, complained of fatigue, and addmitted to decreased sexual interest and potency.
  • (20) The present study attempts to relate this inhibitory effect to the vasoconstrictive potency of ADH.

Purity


Definition:

  • (n.) The condition of being pure.
  • (n.) freedom from foreign admixture or deleterious matter; as, the purity of water, of wine, of drugs, of metals.
  • (n.) Cleanness; freedom from foulness or dirt.
  • (n.) Freedom from guilt or the defilement of sin; innocence; chastity; as, purity of heart or of life.
  • (n.) Freedom from any sinister or improper motives or views.
  • (n.) Freedom from foreign idioms, or from barbarous or improper words or phrases; as, purity of style.

Example Sentences:

  • (1) Fluorination with [18F]acetylhypofluorite yields 6-[18F]fluoro-L-dopa with 95% radiochemical purity; fluorination of the same substrate with [18F]F2 yields a mixture of all three structural isomers in a ratio of 70:16:14 for 6-, 5-, and 2-fluoro compounds.
  • (2) We have compared two new methods (a solvent extraction technique and a method involving a disposable, pre-packed reverse phase chromatography cartridge) with the standard method for determining the radiochemical purity of 99Tcm-HMPAO.
  • (3) The purity and configuration of each isomer of the free acid and N-chloroacetylated derivative were ascertained by: (a) paper chromatography in five solvent systems, (b) elemental analysis, (c) Van Slyke nitrous acid determination of alpha-carbonyl carbon, and (d) Van Slyke ninhydrin determination of alpha-carbonyl carbon, and (e) optical rotation.
  • (4) The observed purity under the selected conditions ranges from 80%-99% and is in accordance with the estimates of the purities made on the basis of the simultaneously recorded pulse shapes.
  • (5) When PMC purified to greater than 99% purity were cultured in methylcellulose with IL-3 and IL-4, approximately 25% of the PMC formed colonies, all of which contained both berberine sulfate-positive and berberine sulfate-negative mast cells.
  • (6) The Nazi party’s office of racial purity claimed that the Jewish character was essentially drug-dependent.
  • (7) It is suggested that more attention be paid to the 'purity' of scales if meaningful interpretation is to be made in treatment assessment.
  • (8) Based on the ratio of plasma membrane marker enzyme activity determined in the nuclear preparation, the purity of the isolated nuclei was ascertained.
  • (9) In contrast to high-purity commercial concentrates, fibronectin was considerably concentrated.
  • (10) The curiously double nature of the virgin in this tale, her purity versus her duplicity, seems unquestionably related to the infantile split mother, as elucidated by Klein--a connection explored in an earlier paper.
  • (11) Using 14C-labelled nitrous bases as starting substrates, labelled nucleosides and nucleotides can be obtained with the 75-80% yield that have radioactive purity of 95-99%.
  • (12) Purity was controlled by disc electrophoresis on polyacrylamide e gels at pH 4.3 and by two dimensional immunoelectrophoresis, respectively.
  • (13) The enzyme obtained by this procedure has both the biochemical and the spectral properties of EPO and shows a reasonable degree of purity, as judged by its rz value.
  • (14) Intact Golgi apparatus have been isolated with good purity from rat testis by a simplified sucrose gradient technique.
  • (15) Finally the higher purity degree of monoclonal antibodies in the cell culture supernatant is also a major advantage of serum free media.
  • (16) Once availed of the fallacy that athletes are role models, there’s a certain purity that feels almost quaint in an era of athlete as brand.
  • (17) A sensitive and specific analytical method was developed to determine the enantiomeric purity of naproxen.
  • (18) It imposes a standard of logical reductionism and methodological purity that not only violates the nature of psychoanalytic knowledge, but imposes an invalid standard of verification and scientific confirmation.
  • (19) Under these conditions, 79--100% of the cells were removed, yielding epithelial fractions of 65--90% purity.
  • (20) The purity of each sample was assured by measurement of the protein concentration of each sample and comparison of this parameter to known normal values for perilymph, serum, and CSF.