(n.) One who, or that which, precedes an event, and indicates its approach; a forerunner; a harbinger.
Example Sentences:
(1) After 4 to 6 hours of recirculation, accumulation of vasoactive amine, 5-hydroxytryptamine, its major metabolite, 5-hydroxyindole acetic acid, and its precursor amino acid, tryptophan were detected.
(2) Compound Z has the properties expected of an oxidized MPT precursor.
(3) Moreover in MIT-1, the size of the novel polypeptide was not that predicted of the precursor (44.9 kDa) but was about 39 kDa, the same size as the authentic GS gamma polypeptide in CYT-4.
(4) It is possible that the elements provide common precursor proteins that reach the secretory intermediate lobe cells through their dendritic branches.
(5) The present in vitro studies show that it is found as beta-endorphin in bovine pituitary slices incubated with radioactive amino acid precursor [35S]methionine.
(6) Our study suggests that a major part of the renal antimineralocorticoid activity of spironolactone may be attributable to minor sulfur-containing metabolites or their precursors having a high renal clearance that affords access to their site of activity via the renal tubular fluid.
(7) When an expression vector containing plasminogen cDNA is transfected into baby hamster kidney cells, the number of drug-resistant colonies as well as the levels of plasminogen secreted by those colonies is lower than observed in similar transfections of other protease precursor genes.
(8) These series were prepared by oxidation of the new hydroquinone precursors.
(9) Administration of one of the precursors of noradrenaline l-DOPA not only prevented the decrease in tissue noradrenaline content in myocardium, but restored completely its reserves, exhausted by electrostimulation of the aortic arch.
(10) By 3 d in the chick embryo, the first neurons detected by antibodies to Ng-CAM are located in the ventral neural tube; these precursors of motor neurons emit well-stained fibers to the periphery.
(11) From this proliferating layer, precursor cells migrate outwards to reach the developing neostriatum in a sequential fashion according to two gradients of histogenesis.
(12) If this is what 70s stoners were laughing at, it feels like they’ve already become acquiescent, passive parts of media-relayed consumer society; precursors of the cathode-ray-frazzled pop-culture exegetists of Tarantino and Kevin Smith in the 90s.
(13) Fiber may have a protective role because of its influence on estrogen metabolism and excretion or because of the endocrine effects of the lignans, a family of compounds formed in the intestine from fiber-associated precursors.
(14) Furthermore it is this small compartment that is preferentially radioactively labelled during short-term incubations with radioactively labelled precursors.
(15) One important consequence of the conservative mode of replication is that cellular enzymes never gain access to the reovirus genome but only to its ssRNA precursors.
(16) The results from rabbit experiments suggest that the 12S protein, probably represents a precursor of TG.
(17) In vitro import assays indicate that ATP12 protein is synthesized as a precursor approximately 3 kDa larger than the mature protein.
(18) Tritium-labeled ribonucleic acid precursors, including cytidine, uridine, and orotic acid, were injected into rats with dated pregnancies (14 to 21 days) and virgin rats.
(19) Pulse-chase experiments showed that the ornithine transcarbamylase precursor and the thiolase traveled from the cytosol to the mitochondria with half-lives of less than 5 min, whereas the three fusion proteins traveled with half-lives of 10-15 min.
(20) The results show that centrally administered serotonin, the serotonin precursor, 5-hydroxytryptophan administered with clorgyline, a selective MAO A inhibitor, quipazine, a serotonin receptor agonist, and fluoxetine, a selective inhibitor of neuronal re-uptake of serotonin, attenuated all paradigms of FIA and apomorphine induced potentiation of FIA.
Trypsinogen
Definition:
(n.) The antecedent of trypsin, a substance which is contained in the cells of the pancreas and gives rise to the trypsin.
Example Sentences:
(1) Both trypsinogen and chymotrypsinogen content decreased after induction of pancreatitis, but there were no significant changes in the proenzyme contents in relation to injection-to-excision times.
(2) The results of experiments in which serum was fractionated by Sephadex G-200 gel filtration suggest that essentially all of the immunoreactive material in normal human serum is trypsinogen.
(3) Thus, in chronic alcoholics the secretory kinetics of trypsinogen and chymotrypsinogen were altered, but trypsin inhibitor secretion remained apparently unaffected.
(4) During the acute phase, it decreased more for trypsinogen I and chymotrypsinogen B than for amylase and lipase, whereas synthesis of the PAP increased dramatically.
(5) In the pancreas, several factors oppose trypsinogen autoactivation, whereas, in the duodenum, all the conditions are favorable for trypsinogen activation by enteropeptidase.
(6) No difference was observed between the streptozotocin pups and the control group in their pancreatic lipase and trypsinogen concentrations after 16 days.
(7) Tumors producing TATI often express tumor-associated trypsinogen.
(8) In the control children, lipase activity increased with advancing age, whereas trypsinogen showed no age-related trend.
(9) In the corpulent rat, both lipase- and chymotrypsinogen-specific activities and both the specific activities and the content of amylase or trypsinogen were lower than those of lean littermates.
(10) Chronic pancreatitis, although less well understood, is also associated with trypsinogen activation within the gland.
(11) These two membrane enzymes activated bovine pancreatic trypsinogen and had the same pH optima in the acid pH range.
(12) The relative rate of synthesis of one of the trypsinogens was unaffected 8 hours after RSD feeding, but was increased 16 hours after RSD feeding.
(13) Cholecystokinin caused a prompt increase in the concentration of both PSTI and trypsinogen.
(14) Both of these stimulators had a reduced effect on ribonuclease synthesis compared with amylase and trypsinogen synthesis but failed to increase myosin synthesis.
(15) Immunoreactive trypsinogen was measured in dried blood spots when the infants were 1 to 4 days old; if the level was elevated (greater than or equal to 140 micrograms per liter), the measurement was repeated (mean age, 38 days); if the level was again elevated, sweat testing was performed (mean age, 49 days).
(16) The rates of reaction of factor X, before and after activation, with the active-site titrant methanesulfonyl fluoride, suggest that the reactivity of the active-site serine residue in factor X is similar to that in trypsinogen and in factor Xa similar to that in trypsin.
(17) The trypsinogen and pancreatic isoamylase assays were also relatively nonspecific (specificity of 82.8% and 85.1%).
(18) Pancreatic trypsinogen and lipase content increased significantly more in younger animals, whereas amylase responses were not different between the two groups.
(19) Neither non-radioactive vitamin B12 nor non-pacreatic protein reduced the 57CoB12-uptake (p greater than 0.5 and p greater than 0.1) Crystalline trypsin and trypsinogen, but not chymotrypsin, also inhibited the uptake (p less than 0.05, p less than 0.02 and p greater than 0.05).
(20) Overall, 95.2 percent of the infants with cystic fibrosis (95 percent confidence interval, 85 to 99 percent) who did not have meconium ileus could be identified with the use of a trypsinogen cutoff level of 140 micrograms per liter on initial testing and 80 micrograms per liter on repeat testing.