(v. t.) To dispose or incline beforehand; to give a predisposition or bias to; as, to predispose the mind to friendship.
(v. t.) To make fit or susceptible beforehand; to give a tendency to; as, debility predisposes the body to disease.
Example Sentences:
(1) The authors conclude that H. pylori alone causes little or no effect on an intact gastric mucosa in the rat, that either intact organisms or bacteria-free filtrates cause similar prolongation and delayed healing of pre-existing ulcers with active chronic inflammation, and that the presence of predisposing factors leading to disruption of gastric mucosal integrity may be required for the H. pylori enhancement of inflammation and tissue damage in the stomach.
(2) Active cytomegalovirus (CMV) infection is associated with immunosuppression and predisposes to the development of life-threatening superinfections in immunocompromised patients.
(3) The approach was to determine the relative importance of predisposing, enabling, and medical need factors in explaining utilization rates among younger and older enrollees of an HMO.
(4) We reviewed the pre-Vietnam contents of the service medical and personnel records of 250 Vietnam combat veterans, in an attempt to identify factors predisposing to the development of posttraumatic stress disorder (PTSD).
(5) In addition to a better understanding of pathogenic mechanisms associated with autoimmunity, the knowledge of these disease-predisposing genes is expected to permit a better classification of often complex syndromes as well as the design of new treatments.
(6) The patients lacked the usual predisposing factors to mucormycosis, ie, diabetes and acidosis, but both had liver disease.
(7) In addition, the postulated personality for PD may predispose to hard work, perspiration, and increased exposure to putative trace elements in the water supply.
(8) Foremost among the predisposing factors were measles (25%), empyema thoraxis (17%), and unconsciousness (13%).
(9) Predisposing factors were coagulopathy and forceps extraction after prolonged labor.
(10) Patients with primary hypogammaglobulinaemia have previously been thought not to be more susceptible to Salmonella infection but a combination of low gastric acidity and impaired humoral immunity may predispose them to such infection.
(11) These observations suggest that IDDM patients have reduced fibrinolytic activity in their retinas, which might predispose them to thromboembolic disease.
(12) One hundred eighteen consecutive patients undergoing valve replacement for aortic stenosis were analyzed to determine the incidence of and predisposing factors to postoperative atrial tachyarrhythmias.
(13) Smoking, which predisposes to peptic ulceration, also appears to reduce mucosal prostaglandin synthesis.
(14) A child should be tested for lupus anticoagulant or anticardiolipin antibody if venous or arterial occlusion occurs without a known predisposing cause, or if there is pulmonary embolism or symptoms or laboratory findings suggestive of a connective tissue disease.
(15) The factors predisposing to and complicating acute renal failure (ARF) in the medical intensive care unit (ICU), and their relative influence on outcome during ARF are unclear.
(16) A large number of factors have been identified which seem to predispose an individual to develop melanoma.
(17) The familial association of epilepsy and cleft lip with or without cleft palate (CL (P)) is analyzed assuming both entities share common genetic predisposing factors.
(18) These findings of enhanced breakage by FUdR exposure in vitro, nevertheless, may suggest that leukemic cells in general are more susceptible to breakage than normal cells, thereby predisposing the former to secondary chromosome rearrangements.
(19) A search was made for predisposing factors and sequelae of diet-induced obesity (DIO) or resistance to DIO (DR).
(20) As a result of calculations genetically predisposed to seizures KM rats were assumed to differ from unpredisposed to seizures Wistar rats in the increase of efficacy of neuronal interactions (excitatory and inhibitory) as a consequence of the enhanced neuronal "reactivity".
Predisposition
Definition:
(n.) The act of predisposing, or the state of being predisposed; previous inclination, tendency, or propensity; predilection; -- applied to the mind; as, a predisposition to anger.
(n.) Previous fitness or adaptation to any change, impression, or purpose; susceptibility; -- applied to material things; as, the predisposition of the body to disease.
Example Sentences:
(1) Pedigree studies have suggested that there may be an inherited predisposition to many apparently nonfamilial colorectal cancers and a genetic model of tumorigenesis in common colorectal cancer has been proposed that includes the activation of dominantly acting oncogenes and the inactivation of growth suppressor genes.
(2) Thus, a4 and a2 alleles of the c-Ha-ras-1 may perhaps be viewed as genetic markers of predisposition to lung, ovarian and thyroid cancer, respectively, in combination with other clinical parameters.
(3) The reported findings strongly support the predisposition hypothesis.
(4) The characteristic predisposition to neoplasia exists, however, as probably does that to diabetes mellitus.
(5) Our knowledge of the pathogenesis of ordinary baldness is far from complete but a genetic predisposition is necessary and androgen production must be present.
(6) Predisposition to pancreatitis relates to duct size rather than stone size per se.
(7) Of CD patients, 92% (50% DR3 and 42% DR5,7) compared to 18% of the controls carry both DQA1*0501 and DQB1*0201 alleles, so that the combination confers an RR of 52, higher than both the risks of the single alleles (DQA1*0501 RR = 19, DQB1*0201 RR = 30), confirming the primary role of the dimer in determining genetic predisposition to CD both in DR3 and in DR5,7 subjects.
(8) For over two decades, evidence has been accumulating that supports a genetic predisposition to alcoholism and the presence of subgroups among alcoholics.
(9) A thromboembolism is sometimes predictable in individuals if there is migraine, visual disturbance, or certain predispositions seen in pregnancy such as toxemia or hypertension.
(10) Questionnaires assessing symptoms, disability and handicap, predisposition to anxiety, and current anxiety and depression were completed by 127 people attending neuro-otology clinics with a major complaint of vertigo or dysequilibrium.
(11) The functional interaction between prostacyclin and thromboxane was examined in terms of a number of risk factors for coronary heart disease (CHD), such as ageing, atherosclerosis, arterial hypertension, diabetes mellitus, obesity, hypokinesia, smoking, alcoholism, sex differences, and predisposition to the disease.
(12) Because the predisposition locus for multiple endocrine neoplasia type 2A (MEN2A) has been mapped to chromosome 10 by genetic linkage analysis, it has become possible to identify gene carriers by following the transmission of linked genetic markers from affected parents to offspring at risk for MEN2A.
(13) The findings suggest that migraine, major depression and anxiety disorders might share common predispositions.
(14) Microstructural rearrangements and nonhomologous recombination in nondisjunction of chromosomes during cell division are considered parallel with mosaicism as one of possible reasons of genetic predisposition.
(15) There was no correlation between specific HLA antigens and predisposition to develop cytomegalovirus infection.
(16) The certainty of a strong genetic predisposition to malignant melanoma was first established over 35 years ago.
(17) The sampling was balanced with respect to age, gender, and predisposition across the three ordinal exposure categories.
(18) Trait anxiety levels (predisposition to anxiety) and personality profiles were recorded in four novice anaesthetists prior to the start of their training in anaesthesia.
(19) Genetic predisposition to diabetes is characterized by immunodeficiency as evident from inadequate levels of antibodies to infectious or noninfectious antigens and absolute and relative deficiency in spleen lymphocyte subsets and total numbers of spleen cells.
(20) Tumor suppressor genes have been identified by genetic analysis either as loci associated with an inherited predisposition to certain tumors or by mapping studies that demonstrate allelic loss (reduction to homozygosity or loss of heterozygosity) during tumor development.