(n.) The act of predisposing, or the state of being predisposed; previous inclination, tendency, or propensity; predilection; -- applied to the mind; as, a predisposition to anger.
(n.) Previous fitness or adaptation to any change, impression, or purpose; susceptibility; -- applied to material things; as, the predisposition of the body to disease.
Example Sentences:
(1) Pedigree studies have suggested that there may be an inherited predisposition to many apparently nonfamilial colorectal cancers and a genetic model of tumorigenesis in common colorectal cancer has been proposed that includes the activation of dominantly acting oncogenes and the inactivation of growth suppressor genes.
(2) Thus, a4 and a2 alleles of the c-Ha-ras-1 may perhaps be viewed as genetic markers of predisposition to lung, ovarian and thyroid cancer, respectively, in combination with other clinical parameters.
(3) The reported findings strongly support the predisposition hypothesis.
(4) The characteristic predisposition to neoplasia exists, however, as probably does that to diabetes mellitus.
(5) Our knowledge of the pathogenesis of ordinary baldness is far from complete but a genetic predisposition is necessary and androgen production must be present.
(6) Predisposition to pancreatitis relates to duct size rather than stone size per se.
(7) Of CD patients, 92% (50% DR3 and 42% DR5,7) compared to 18% of the controls carry both DQA1*0501 and DQB1*0201 alleles, so that the combination confers an RR of 52, higher than both the risks of the single alleles (DQA1*0501 RR = 19, DQB1*0201 RR = 30), confirming the primary role of the dimer in determining genetic predisposition to CD both in DR3 and in DR5,7 subjects.
(8) For over two decades, evidence has been accumulating that supports a genetic predisposition to alcoholism and the presence of subgroups among alcoholics.
(9) A thromboembolism is sometimes predictable in individuals if there is migraine, visual disturbance, or certain predispositions seen in pregnancy such as toxemia or hypertension.
(10) Questionnaires assessing symptoms, disability and handicap, predisposition to anxiety, and current anxiety and depression were completed by 127 people attending neuro-otology clinics with a major complaint of vertigo or dysequilibrium.
(11) The functional interaction between prostacyclin and thromboxane was examined in terms of a number of risk factors for coronary heart disease (CHD), such as ageing, atherosclerosis, arterial hypertension, diabetes mellitus, obesity, hypokinesia, smoking, alcoholism, sex differences, and predisposition to the disease.
(12) Because the predisposition locus for multiple endocrine neoplasia type 2A (MEN2A) has been mapped to chromosome 10 by genetic linkage analysis, it has become possible to identify gene carriers by following the transmission of linked genetic markers from affected parents to offspring at risk for MEN2A.
(13) The findings suggest that migraine, major depression and anxiety disorders might share common predispositions.
(14) Microstructural rearrangements and nonhomologous recombination in nondisjunction of chromosomes during cell division are considered parallel with mosaicism as one of possible reasons of genetic predisposition.
(15) There was no correlation between specific HLA antigens and predisposition to develop cytomegalovirus infection.
(16) The certainty of a strong genetic predisposition to malignant melanoma was first established over 35 years ago.
(17) The sampling was balanced with respect to age, gender, and predisposition across the three ordinal exposure categories.
(18) Trait anxiety levels (predisposition to anxiety) and personality profiles were recorded in four novice anaesthetists prior to the start of their training in anaesthesia.
(19) Genetic predisposition to diabetes is characterized by immunodeficiency as evident from inadequate levels of antibodies to infectious or noninfectious antigens and absolute and relative deficiency in spleen lymphocyte subsets and total numbers of spleen cells.
(20) Tumor suppressor genes have been identified by genetic analysis either as loci associated with an inherited predisposition to certain tumors or by mapping studies that demonstrate allelic loss (reduction to homozygosity or loss of heterozygosity) during tumor development.
Propensity
Definition:
(n.) The quality or state of being propense; natural inclination; disposition to do good or evil; bias; bent; tendency.
Example Sentences:
(1) Fractures which occur near the base of the dens have a low propensity to unite spontaneously.
(2) There was also no significant correlation when prognostic factors were compared to uptake in the individual organ systems except that T cell disease was associated with a significantly greater propensity for lymph node uptake.
(3) Three strains of C. burnetii were studied because of the purported propensity of each strain to cause acute or chronic disease and to be resistant or susceptible to antibiotics.
(4) Thus, an abnormality of neutrophil oxidative metabolism cannot explain the propensity to bacterial infections in sickle cell disease.
(5) The stroma has a propensity to accumulate fluid and to create macroscopic cystic spaces.
(6) Myelography and cytology studies are necessary in the evaluation of all newly diagnosed patients with medulloblastoma and may also be indicated for patients with other brain tumors with a known propensity for dissemination.
(7) Where UV radiation is restricted, individual propensity to rickets within a given Asian community is mainly determined by dietary factors.
(8) The polymorphisms seen could provide useful linkage markers in locating the chromosomal sites of the genetic loci responsible for raised blood pressure in the SHR and the propensity to strokes in the SHRSP.
(9) A propensity for elevated shear in the deep cartilage layer near the contact periphery, observed in nearly all computed stress distributions, is consistent with previous experimental findings of fissuring at that level in the impulsively loaded rabbit knee.
(10) The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype.
(11) Patients with well-differentiated adenosquamous carcinoma persisted in having a worse prognosis (58.3% ten-year survival rate), compared with adenocarcinoma (84.3% ten-year survival rate), which was explained by the propensity of adenosquamous carcinoma to deeply invade the myometrium.
(12) College students completed a 17-item scale measuring the "propensity to argue controversial topics" and 7 other nominal-scale independent variables.
(13) Mating propensity in eight all-female laboratory lines was measured.
(14) In assortative mating systems modifiers favoring reduced assortment propensities tend to increase.
(15) However, CGS 19755 did not show a unique propensity for learning and memory disruption compared to other anticonvulsants.
(16) The results of ecological studies appear to be more consistent that those dealing with "specific" psychosomatic disorders and suggest that man has a general psychophysical propensity to disease.
(17) The propensity for specific fragmentation of peptide D seems to be correlated to the repetitive sequence, (Gly-Ser)2.
(18) This work clearly demonstrates the greater propensity of trans-dichlorodiammineplatinum(II) to form histone-histone and histone-DNA crosslinks compared with the antitumor active cis isomer, which binds first to the DNA and only forms crosslinks to the histones when the nucleosome core is heavily loaded with platinum.
(19) The rapid progression of disease, the high incidence of micrometastases (over 80%) at diagnosis, and the propensity of hematogenous spread to the bone marrow and the central nervous system (CNS) as well as the clinico-pathologic 'clusters' associated with particular presenting sites distinguish the pediatric forms of disease.
(20) Slower ventricular rates during atrial fibrillation would suggest an increased propensity for concealed conduction in the enhanced AV node conduction group than in the group with an accessory pathway.