(n.) The act of predisposing, or the state of being predisposed; previous inclination, tendency, or propensity; predilection; -- applied to the mind; as, a predisposition to anger.
(n.) Previous fitness or adaptation to any change, impression, or purpose; susceptibility; -- applied to material things; as, the predisposition of the body to disease.
Example Sentences:
(1) Pedigree studies have suggested that there may be an inherited predisposition to many apparently nonfamilial colorectal cancers and a genetic model of tumorigenesis in common colorectal cancer has been proposed that includes the activation of dominantly acting oncogenes and the inactivation of growth suppressor genes.
(2) Thus, a4 and a2 alleles of the c-Ha-ras-1 may perhaps be viewed as genetic markers of predisposition to lung, ovarian and thyroid cancer, respectively, in combination with other clinical parameters.
(3) The reported findings strongly support the predisposition hypothesis.
(4) The characteristic predisposition to neoplasia exists, however, as probably does that to diabetes mellitus.
(5) Our knowledge of the pathogenesis of ordinary baldness is far from complete but a genetic predisposition is necessary and androgen production must be present.
(6) Predisposition to pancreatitis relates to duct size rather than stone size per se.
(7) Of CD patients, 92% (50% DR3 and 42% DR5,7) compared to 18% of the controls carry both DQA1*0501 and DQB1*0201 alleles, so that the combination confers an RR of 52, higher than both the risks of the single alleles (DQA1*0501 RR = 19, DQB1*0201 RR = 30), confirming the primary role of the dimer in determining genetic predisposition to CD both in DR3 and in DR5,7 subjects.
(8) For over two decades, evidence has been accumulating that supports a genetic predisposition to alcoholism and the presence of subgroups among alcoholics.
(9) A thromboembolism is sometimes predictable in individuals if there is migraine, visual disturbance, or certain predispositions seen in pregnancy such as toxemia or hypertension.
(10) Questionnaires assessing symptoms, disability and handicap, predisposition to anxiety, and current anxiety and depression were completed by 127 people attending neuro-otology clinics with a major complaint of vertigo or dysequilibrium.
(11) The functional interaction between prostacyclin and thromboxane was examined in terms of a number of risk factors for coronary heart disease (CHD), such as ageing, atherosclerosis, arterial hypertension, diabetes mellitus, obesity, hypokinesia, smoking, alcoholism, sex differences, and predisposition to the disease.
(12) Because the predisposition locus for multiple endocrine neoplasia type 2A (MEN2A) has been mapped to chromosome 10 by genetic linkage analysis, it has become possible to identify gene carriers by following the transmission of linked genetic markers from affected parents to offspring at risk for MEN2A.
(13) The findings suggest that migraine, major depression and anxiety disorders might share common predispositions.
(14) Microstructural rearrangements and nonhomologous recombination in nondisjunction of chromosomes during cell division are considered parallel with mosaicism as one of possible reasons of genetic predisposition.
(15) There was no correlation between specific HLA antigens and predisposition to develop cytomegalovirus infection.
(16) The certainty of a strong genetic predisposition to malignant melanoma was first established over 35 years ago.
(17) The sampling was balanced with respect to age, gender, and predisposition across the three ordinal exposure categories.
(18) Trait anxiety levels (predisposition to anxiety) and personality profiles were recorded in four novice anaesthetists prior to the start of their training in anaesthesia.
(19) Genetic predisposition to diabetes is characterized by immunodeficiency as evident from inadequate levels of antibodies to infectious or noninfectious antigens and absolute and relative deficiency in spleen lymphocyte subsets and total numbers of spleen cells.
(20) Tumor suppressor genes have been identified by genetic analysis either as loci associated with an inherited predisposition to certain tumors or by mapping studies that demonstrate allelic loss (reduction to homozygosity or loss of heterozygosity) during tumor development.
Susceptibility
Definition:
(n.) The state or quality of being susceptible; the capability of receiving impressions, or of being affected.
(n.) Specifically, capacity for deep feeling or emotional excitement; sensibility, in its broadest acceptation; impressibility; sensitiveness.
Example Sentences:
(1) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(2) An experimental Anaplasma marginale infection was induced in a splenectomized mule deer (Odocoileus hemionus hemionus) which persisted subclinically at least 376 days as detected by subinoculation into susceptible cattle.
(3) One rat strain (TAS) is susceptible to the anticoagulant and lethal effects of warfarin and the other two strains are homozygous for warfarin resistance genes from either wild Welsh (HW) or Scottish (HS) rats.
(4) When irradiated circular DNA, previously nicked by T4 endonuclease V, is briefly exposed to elevated temperature, the DAN becomes susceptible to the action of exonuclease V, and pyrimidine dimers are selectively released.
(5) Cytolytic T lymphocytes lysing virus-infected and uninfected myocytes and heart-reactive autoantibodies occur in both myocarditis-susceptible strains.
(6) Although each of palate and limb is concurrently susceptible to epigenetic regulation, their differential intrinsic genomic capabilities appear to have been uncoupled.
(7) Peptidoglycan of MRSA grown in the presence of cefazolin was susceptible to lysis by respiratory mucus.
(8) Characerization of further parameters such as relative susceptibility to tolerance induction and relative degree of specificity was not possible with the use of KLH as the antigen.
(9) Most of the infection was attributed to T. parva parva by application of field ticks to susceptible cattle.
(10) An in vitro bioassay was used to examine [14C]glucose incorporation into polysaccharides in albumen glands (AGs) of susceptible M-line Biomphalaria glabrata infected with the NMRI strain of Schistosoma mansoni.
(11) In the DAUDI cell system, the acquired capability of tumor cell variants to grow in the presence of a relatively high concentration of vinblastine (VBL) is associated with a marked increase to NK and LAK susceptibility.
(12) From 1983 to 1986 more than 2000 non-penicillinase producing Neisseria gonorrhoeae from Amsterdam, The Hague and Rotterdam were auxotyped and screened for susceptibility to 10 antibiotics by MIC determination.
(13) The effect of modifying the periodate-susceptible methionine residues in chicken ovotransferrin was small but significant.
(14) This procedure generated a number of VI-like effects, supporting the notion that VI behavior can be construed as a special case of an interaction between the organism's function relating reinforcement susceptibilities to chain length and the experimenter's function relating probabilities of reinforcement to chain length.
(15) A large number of recently isolated bacterial pathogens were tested for susceptibility to cephalexin and cephaloglycin by the replica inoculating method.
(16) In general, enzyme activity was less susceptible to HA during the first week after birth than at later ages, some brain areas such as the hypothalamus showing significant alterations in some enzymes throughout development, and in all enzymes at adulthood.
(17) These results might help to explain why only a minority of individuals with a susceptible HLA type develop uveitis, as well as the variable incidence of disease in HLA-identical populations of different ethnic backgrounds.
(18) In this sense, there is evidence that in genetically susceptible individuals, environmental stresses can influence the long-term level of arterial pressure via the central and peripheral neural autonomic pathways.
(19) However, the average age at onset of lymphoma varied considerably among the different AKXD strains, suggesting that they have segregated several loci that affect lymphoma susceptibility.
(20) This model of protective immunity in a Brugia-susceptible small rodent may provide a useful system for identification of molecularly defined filarial-protective immunogens.