(a.) Highest in rank, authority, character, importance, or degree; most considerable or important; chief; main; as, the principal officers of a Government; the principal men of a state; the principal productions of a country; the principal arguments in a case.
(a.) Of or pertaining to a prince; princely.
(n.) A leader, chief, or head; one who takes the lead; one who acts independently, or who has controlling authority or influence; as, the principal of a faction, a school, a firm, etc.; -- distinguished from a subordinate, abettor, auxiliary, or assistant.
(n.) The chief actor in a crime, or an abettor who is present at it, -- as distinguished from an accessory.
(n.) A chief obligor, promisor, or debtor, -- as distinguished from a surety.
(n.) One who employs another to act for him, -- as distinguished from an agent.
(n.) A thing of chief or prime importance; something fundamental or especially conspicuous.
(n.) A capital sum of money, placed out at interest, due as a debt or used as a fund; -- so called in distinction from interest or profit.
(n.) The construction which gives shape and strength to a roof, -- generally a truss of timber or iron, but there are roofs with stone principals. Also, loosely, the most important member of a piece of framing.
(n.) In English organs the chief open metallic stop, an octave above the open diapason. On the manual it is four feet long, on the pedal eight feet. In Germany this term corresponds to the English open diapason.
(n.) A heirloom; a mortuary.
(n.) The first two long feathers of a hawk's wing.
(n.) One of turrets or pinnacles of waxwork and tapers with which the posts and center of a funeral hearse were formerly crowned.
(n.) A principal or essential point or rule; a principle.
Example Sentences:
(1) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(2) While stereology is the principal technique, particularly in its application to the parenchyma, other compartments such as the airways and vasculature demand modifications or different methods altogether.
(3) Chromatography and immunoassays are the two principal techniques used in research and clinical laboratories for the measurement of drug concentrations in biological fluids.
(4) This paper reports, principally, the caries results of the first three surveys of 5, 12 and 5-year-olds undertaken at the end of 1987, 1988 and 1989, respectively.
(5) Rigidly fixing the pubic symphysis stiffened the model and resulted in principal stress patterns that did not reflect trabecular density or orientations as well as those of the deformable pubic symphysis model.
(6) The binding parameters indicate that the principal activating effect of UMP is not simply to increase the affinity of the enzyme for glucose.
(7) Mononuclear phagocytic cells from patients with either principal form of leprosy functioned similarly to normal monocytes in phagocytosis while their fungicidal activity for C. pseudotropicalis was statistically significantly altered and was more evident in the lepromatous than in the tuberculoid type.
(8) In the terminal segment of the hamster epididymidis there was some evidence of micro-merocrine protein secretion a the level of the principal cells and clear evidence of granular secretion in the light cells, presumable of glycoproteins.
(9) In the analysis of background fluorescence, the principal components were, as for the two-step technique, autofluorescence and propidium spectral overlap.
(10) However, at Period B, neutrophil numbers in the BAL fluid were increased in the principal but not in the control animals.
(11) Principal conclusions are: 1) rapid change to predominantly heterosexual HIV transmission can occur in North America, with serious societal impact; 2) gender-specific clinical features can lead to earlier diagnosis of HIV infection in women; 3) HIV infection in women does not pursue an inherently more rapid course than that observed in men.
(12) The concentrations of the principal extratesticular androgens and estradiol do not seem to have a quantitative influence on these androphilic proteins either.
(13) A principal function of GPIb is its attachment to von Willebrand Factor (vWF) on injured blood vessels which leads to the adhesion of platelets to these vessels.
(14) The principal variables influencing a particular configuration and their effects are indicated.
(15) The principal form of HMTs produced by these human peripheral blood monocytes has been subjected to biochemical, functional, and serological characterization.
(16) Micronutrient antioxidants such as alpha-tocopherol, the principal lipid-soluble antioxidant, assume potential significance because levels can be manipulated by dietary measures without resulting in side effects.
(17) Cytochrome oxidase histochemistry revealed patchy patterns of the enzyme activity in transverse sections through the caudal part of the ventral subnucleus of the principal sensory trigeminal nucleus, interpolar spinal trigeminal nucleus, and layer IV of the caudal spinal trigeminal nucleus in the cat.
(18) 3. an up-to-date review of the principal methods and systems used to measure the sedimentation rate--Automation of the Westergren initial methodology.
(19) • Queen Margaret Union, one of the University of Glasgow's two student unions, says 200 students there are marching on the principal's office at the moment to present an anti-cuts petition.
(20) This observation provides corroboration for the identification of the principal CCK-I neuron in the rat olfactory bulb as the centrally projecting middle tufted cell.
Rule
Definition:
(a.) That which is prescribed or laid down as a guide for conduct or action; a governing direction for a specific purpose; an authoritative enactment; a regulation; a prescription; a precept; as, the rules of various societies; the rules governing a school; a rule of etiquette or propriety; the rules of cricket.
(a.) Uniform or established course of things.
(a.) Systematic method or practice; as, my ule is to rise at six o'clock.
(a.) Ordibary course of procedure; usual way; comon state or condition of things; as, it is a rule to which there are many exeptions.
(a.) Conduct in general; behavior.
(a.) The act of ruling; administration of law; government; empire; authority; control.
(a.) An order regulating the practice of the courts, or an order made between parties to an action or a suit.
(a.) A determinate method prescribed for performing any operation and producing a certain result; as, a rule for extracting the cube root.
(a.) A general principle concerning the formation or use of words, or a concise statement thereof; thus, it is a rule in England, that s or es , added to a noun in the singular number, forms the plural of that noun; but "man" forms its plural "men", and is an exception to the rule.
(a.) A straight strip of wood, metal, or the like, which serves as a guide in drawing a straight line; a ruler.
(a.) A measuring instrument consisting of a graduated bar of wood, ivory, metal, or the like, which is usually marked so as to show inches and fractions of an inch, and jointed so that it may be folded compactly.
(a.) A thin plate of metal (usually brass) of the same height as the type, and used for printing lines, as between columns on the same page, or in tabular work.
(a.) A composing rule. See under Conposing.
(n.) To control the will and actions of; to exercise authority or dominion over; to govern; to manage.
(n.) To control or direct by influence, counsel, or persuasion; to guide; -- used chiefly in the passive.
(n.) To establish or settle by, or as by, a rule; to fix by universal or general consent, or by common practice.
(n.) To require or command by rule; to give as a direction or order of court.
(n.) To mark with lines made with a pen, pencil, etc., guided by a rule or ruler; to print or mark with lines by means of a rule or other contrivance effecting a similar result; as, to rule a sheet of paper of a blank book.
(v. i.) To have power or command; to exercise supreme authority; -- often followed by over.
(v. i.) To lay down and settle a rule or order of court; to decide an incidental point; to enter a rule.
(v. i.) To keep within a (certain) range for a time; to be in general, or as a rule; as, prices ruled lower yesterday than the day before.
Example Sentences:
(1) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(2) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(3) Before issuing the ruling, the judge Shaban El-Shamy read a lengthy series of remarks detailing what he described as a litany of ills committed by the Muslim Brotherhood, including “spreading chaos and seeking to bring down the Egyptian state”.
(4) Also critical to Mr Smith's victory was the decision over lunch of the MSF technical union's delegation to abstain on the rule changes.
(5) Titre in newborn was as a rule lower than the corresponding titre of mother.
(6) Former lawmaker and historian Faraj Najm said the ruling resets Libya “back to square one” and that the choice now faced by the Tobruk-based parliament is “between bad and worse”.
(7) The exception to this rule is a cyst which can be safely aspirated under controlled conditions.
(8) This situation should lead to discuss preventive rules.
(9) Cas reduced it further to four, but the decision effectively ends Platini’s career as a football administrator because – as he pointedly noted – it rules him out of standing for the Fifa presidency in 2019.
(10) Paul Johnson, the IFS director, said: “Osborne’s new fiscal charter is much more constraining than his previous fiscal rules.
(11) Models with a C8-symmetry and D4-symmetry can be ruled out.
(12) CEA and bacterial antigens were not detected in the material, and the presence of alpha-fetoprotein, HLA and blood-group antigens may be ruled out on account of their respective molecular weights.
(13) In his notorious 1835 Minute on Education , Lord Macaulay articulated the classic reason for teaching English, but only to a small minority of Indians: “We must do our best to form a class who may be interpreters between us and the millions whom we govern; a class of persons, Indians in blood and colour, but English in taste, in opinions, in morals and in intellect.” The language was taught to a few to serve as intermediaries between the rulers and the ruled.
(14) In fact, if the roundtable operated by the rules it publishes, most of its members might have been thrown out.
(15) Injections of l-amphetamine were not effective, ruling out non-specific effects of pH, osmolarity and the like and also ruling out noradrenergic actions as explanations of the behavioral effects.
(16) My father wrote to the official who had ruled I could not ride and asked for Championships to be established for girls.
(17) The prediction rule performed well when used on a test set of data (area, 0.76).
(18) Analysts say Zuma's lawyers may try to reach agreement with the prosecutors, while he can also appeal against yesterday's ruling before the constitutional court.
(19) The ruling centre-right coalition government of Angela Merkel was dealt a blow by voters in a critical regional election on Sunday after the centre-left opposition secured a wafer-thin victory, setting the scene for a tension-filled national election in the autumn when everything will be up for grabs.
(20) But employers who have followed a fair procedure may have the right to discipline or finally dismiss any smoker who refuses to accept the new rules.