(a.) Highest in rank, authority, character, importance, or degree; most considerable or important; chief; main; as, the principal officers of a Government; the principal men of a state; the principal productions of a country; the principal arguments in a case.
(a.) Of or pertaining to a prince; princely.
(n.) A leader, chief, or head; one who takes the lead; one who acts independently, or who has controlling authority or influence; as, the principal of a faction, a school, a firm, etc.; -- distinguished from a subordinate, abettor, auxiliary, or assistant.
(n.) The chief actor in a crime, or an abettor who is present at it, -- as distinguished from an accessory.
(n.) A chief obligor, promisor, or debtor, -- as distinguished from a surety.
(n.) One who employs another to act for him, -- as distinguished from an agent.
(n.) A thing of chief or prime importance; something fundamental or especially conspicuous.
(n.) A capital sum of money, placed out at interest, due as a debt or used as a fund; -- so called in distinction from interest or profit.
(n.) The construction which gives shape and strength to a roof, -- generally a truss of timber or iron, but there are roofs with stone principals. Also, loosely, the most important member of a piece of framing.
(n.) In English organs the chief open metallic stop, an octave above the open diapason. On the manual it is four feet long, on the pedal eight feet. In Germany this term corresponds to the English open diapason.
(n.) A heirloom; a mortuary.
(n.) The first two long feathers of a hawk's wing.
(n.) One of turrets or pinnacles of waxwork and tapers with which the posts and center of a funeral hearse were formerly crowned.
(n.) A principal or essential point or rule; a principle.
Example Sentences:
(1) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(2) While stereology is the principal technique, particularly in its application to the parenchyma, other compartments such as the airways and vasculature demand modifications or different methods altogether.
(3) Chromatography and immunoassays are the two principal techniques used in research and clinical laboratories for the measurement of drug concentrations in biological fluids.
(4) This paper reports, principally, the caries results of the first three surveys of 5, 12 and 5-year-olds undertaken at the end of 1987, 1988 and 1989, respectively.
(5) Rigidly fixing the pubic symphysis stiffened the model and resulted in principal stress patterns that did not reflect trabecular density or orientations as well as those of the deformable pubic symphysis model.
(6) The binding parameters indicate that the principal activating effect of UMP is not simply to increase the affinity of the enzyme for glucose.
(7) Mononuclear phagocytic cells from patients with either principal form of leprosy functioned similarly to normal monocytes in phagocytosis while their fungicidal activity for C. pseudotropicalis was statistically significantly altered and was more evident in the lepromatous than in the tuberculoid type.
(8) In the terminal segment of the hamster epididymidis there was some evidence of micro-merocrine protein secretion a the level of the principal cells and clear evidence of granular secretion in the light cells, presumable of glycoproteins.
(9) In the analysis of background fluorescence, the principal components were, as for the two-step technique, autofluorescence and propidium spectral overlap.
(10) However, at Period B, neutrophil numbers in the BAL fluid were increased in the principal but not in the control animals.
(11) Principal conclusions are: 1) rapid change to predominantly heterosexual HIV transmission can occur in North America, with serious societal impact; 2) gender-specific clinical features can lead to earlier diagnosis of HIV infection in women; 3) HIV infection in women does not pursue an inherently more rapid course than that observed in men.
(12) The concentrations of the principal extratesticular androgens and estradiol do not seem to have a quantitative influence on these androphilic proteins either.
(13) A principal function of GPIb is its attachment to von Willebrand Factor (vWF) on injured blood vessels which leads to the adhesion of platelets to these vessels.
(14) The principal variables influencing a particular configuration and their effects are indicated.
(15) The principal form of HMTs produced by these human peripheral blood monocytes has been subjected to biochemical, functional, and serological characterization.
(16) Micronutrient antioxidants such as alpha-tocopherol, the principal lipid-soluble antioxidant, assume potential significance because levels can be manipulated by dietary measures without resulting in side effects.
(17) Cytochrome oxidase histochemistry revealed patchy patterns of the enzyme activity in transverse sections through the caudal part of the ventral subnucleus of the principal sensory trigeminal nucleus, interpolar spinal trigeminal nucleus, and layer IV of the caudal spinal trigeminal nucleus in the cat.
(18) 3. an up-to-date review of the principal methods and systems used to measure the sedimentation rate--Automation of the Westergren initial methodology.
(19) • Queen Margaret Union, one of the University of Glasgow's two student unions, says 200 students there are marching on the principal's office at the moment to present an anti-cuts petition.
(20) This observation provides corroboration for the identification of the principal CCK-I neuron in the rat olfactory bulb as the centrally projecting middle tufted cell.
Theory
Definition:
(n.) A doctrine, or scheme of things, which terminates in speculation or contemplation, without a view to practice; hypothesis; speculation.
(n.) An exposition of the general or abstract principles of any science; as, the theory of music.
(n.) The science, as distinguished from the art; as, the theory and practice of medicine.
(n.) The philosophical explanation of phenomena, either physical or moral; as, Lavoisier's theory of combustion; Adam Smith's theory of moral sentiments.
Example Sentences:
(1) This theory was confirmed by product analysis and by measuring the affinity of the substrate for the enzyme by its inhibition of p-nitrophenyl glucoside hydrolysis.
(2) The position of the cyst supports the theory that branchial cysts are congenital in origin.
(3) It helped pay the bills and caused me to ponder on the disconnection between theory and reality.
(4) Implications of the theory for hypothesis testing, theory construction, and scales of measurement are considered.
(5) This observation, reinforced by simultaneous determinations of cortisol levels in the internal spermatic and antecubital veins, practically excluded the validity of the theory of adrenal hormonal suppression of testicular tissues.
(6) In 1935, Einstein challenged the prevailing interpretation of quantum theory.
(7) These results are interpreted in terms of the accessory binding site theory of Ariëns, and suggest the existence of different accessory binding sites on the Ascaris GABA receptor.
(8) September 11 conspiracies Facebook Twitter Pinterest September 11 conspiracy theories.
(9) This theory is supported by a previous experimental report.
(10) On the assumption of a distribution in properties of the suspension according to the theory of Bruggeman, the capacitance is calculated to have a value of about one half this.5.
(11) These findings do not support the theory that 5-HT1C receptor activation causes migraine.
(12) Only one part of the theory of Alajouanine and colleagues has been confirmed by our experiments for our results have shown that there is a very close correlation between semantic paraphasias and disorders of semantic differentiation whilst no correlation can be found between phonemic paraphasias and disturbances in auditory phonemic discrimination.
(13) A new theory for the peculiar site selection of cholesteatomas of the external auditory canal is postulated.
(14) However, our theory differs in several important respects from the latter efforts.
(15) This paper provides an overview of the theory, indicating its contributions--such as a basis for individual psychotherapy of severe disorders and a more effective understanding of countertransference--and its shortcomings--such as lack of an explanation for the effects of physical and cognitive factors on object relatedness.
(16) The various theories of carpal tunnel syndrome (CTS) are reviewed.
(17) Comparison with values predicted from theory shows that the distribution of protein among the various cross-linked species, obtained after different extents of exposure to cross-linker, is consistent with a two-layered arrangement of subunits involving one type of interaction between subunits from different layers and another between subunits within the same layer.
(18) For each theory, a constraint on preformance is proposed based on interference between the "analytic" and "synthetic" pitch perception modes.
(19) Republican presidential hopeful Scott Walker has refused to say whether he believes in the theory of evolution, arguing that it is “a question a politician shouldn’t be involved in one way or the other”.
(20) These findings support the theory that plasma-membrane-cytoskeleton interactions have a role in the expression of specific immunity; the findings also identify new areas that should be considered in trying to understand the primary immunodeficiency diseases.