(1) An important new insight is provided by the observation that agonists (e.g., CCK or acetylcholine) that act to stimulate the hydrolysis of phosphatidylinositides, when acting for a short period (10-20 min), induce an enhanced responsiveness of islets to glucose, i.e., proemial sensitization.
(2) Prior exposure to 1 mM acetylcholine induced a similar proemial sensitization to a subsequent challenge with glucose.