(a.) Broken down in respect of rectitude, principle, virtue, or decency; openly and shamelessly immoral or vicious; dissolute; as, profligate man or wretch.
(n.) An abandoned person; one openly and shamelessly vicious; a dissolute person.
(v. t.) To drive away; to overcome.
Example Sentences:
(1) But this is not to say that I do not have a working knowledge of true bedsitters - and yes, they do still exist, in spite of estate agents' profligate use of the term 'studio flat'.
(2) But it relies too much on the myth that booms enrich everyone, a myth easily exposed by pointing out that under that supposedly profligate Labour administration, now accused of recklessly taking from the rich and giving to the poor, the gap between the richest and the poorest didn't narrow.
(3) "With a 53 per cent increase in energy consumption forecast by 2035, those who are commercially savvy will recognise that in a resource poor future, we cannot be captured by a profligate economic model from the past.
(4) Reasonable use” sounds … well, reasonable, but a “use it or lose it” clause incentivizes profligate use: if you don’t use your historic water allocation in a beneficial way, you forfeit your water rights, Gray said.
(5) The coalition succeeded an unbelievably profligate government that took state spending from 34% of GDP to over 45% in a decade .
(6) Other critics say low water prices are the culprits as they result in profligate water use and low investment in water-efficient infrastructure.
(7) All the debt ceiling ends up becoming is a political football used by the opposition party to suggest the government are profligate spenders.
(8) He believes that Osborne's decision to veto the measures in February shows that the Tories want to put spending cuts ahead of tackling child poverty as he seeks to depict Labour as profligate.
(9) The credit crunch hit, which might have been terminal to a project so palpably of the profligate boom years, but then the cavalry appeared, in the form of the property arm of the ruling family of Qatar.
(10) Thatcherism liked to present itself as a rejection of the postwar, state-driven, more profligate way of doing things.
(11) There is no reason why a constitutional solution that involves debt limitation should not command a large measure of public acceptance, especially in debtor countries, which have experienced the political and economic damage caused by previous profligate governments.
(12) In Brussels, right-of-centre German economists, who until recently dominated the European Central Bank's main decision-making board, lobbied for a "can't-pay, won't-pay" stance towards southern European countries seen as profligate spenders who need to understand the moral hazard of raising their living standards on a mountain of debt.
(13) The latest shock wave has served to ram home the reality that this remains first of all a crisis of the banks and the private sector – not, as the British government would have it, of profligate governments and public debt, which only ballooned to fill the gap left by market failure.
(14) Election officials have also disqualified Raja Pervaiz Ashraf, the man who until just a few weeks ago was the country's prime minister, under articles ensuring candidates are, among many other things, "sagacious, righteous and non-profligate".
(15) As inspectors from Brussels demanded answers this week from the Spanish government about how it plans to bring profligate regional governments under control, senior officials admitted they were clueless as to the real size of the debt in the biggest region – party-loving Andalucía.
(16) "People have far more confidence in Britain than in many other western countries who have got into trouble through profligate economic policies," he said.
(17) London, which has less annual rainfall than cities such as Athens and Sydney, is classed as "seriously water-stressed" by the Environment Agency , but critics of the Beckton plant – including former mayor of London Ken Livingstone – told the inquiry that desalination was energy-profligate, unnecessary and unsustainable.
(18) More and more people feel the gap between the profligate promises of individual freedom and sovereignty, and the incapacity of their political and economic organisations to realise them.
(19) His party has no members of parliament, a situation unlikely to change at the next election, and offers promiscuous and profligate policies that add up to errant nonsense as a platform for government.
(20) That debacle shows the Conservatives as being as profligate as sailors on shore leave.
Proliferation
Definition:
(n.) The continuous development of cells in tissue formation; cell formation.
(n.) The production of numerous zooids by budding, especially when buds arise from other buds in succession.
Example Sentences:
(1) The most actively proliferating region of the excurrent duct system is zone 3 of the epididymis, whereas the least active region is the ductuli efferentes.
(2) We also show that proliferation of primary amnion cells is not dependent on a high c-fos expression, suggesting that the function of c-fos is more likely to be associated with other cellular functions in the differentiated amnion cell.
(3) However, when cross-linked to anti-CD4 or anti-CD8 antibodies a markedly enhanced proliferation of the corresponding subpopulation is observed.
(4) Quantitative determinations indicate that the amount of PBG-D mRNA is modulated both by the erythroid nature of the tissue and by cell proliferation, probably at the transcriptional level.
(5) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(6) 10D1 mAb induced a substantial proliferation of peripheral blood T cells when cross-linked with goat anti-mouse Ig antibody.
(7) Proliferation assays using F3 showed that 15 (14 CD4+ and 1 CD8+) of the 18 isolated clones were specific for T. gondii.
(8) After vascular injury, smooth muscle cells proliferate, reaching a maximum rate at day 2.
(9) Recent studies have shown that an aberration in platelet-derived growth factor gene expression is unlikely to be a factor in proliferation of smooth-muscle cells.
(10) During capillary growth when endothelial cells (EC) undergo extensive proliferation and migration and pericytes are scarce, hyaluronic acid (HA) levels are elevated.
(11) The macrophage-derived product, interleukin 1 (IL 1) is thought to play an important regulatory role in the proliferation of T lymphocytes; however, its mechanism of action is unknown.
(12) T cell costimulation by molecules on the antigen presenting cell (APC) is required for optimal T cell proliferation.
(13) Our prospective study has defined a number of important variables in patients with clinical evidence of mast cell proliferation that can predict both the presence of SMCD and the likelihood of fatal disease.
(14) However, a highly significant upward shift of the proliferating cell compartment was observed in the cancer group, resulting in a specific modification of the [3H]TDR labeling pattern in 6 of 17 specimens.
(15) Anti-5'-NT antibodies had no effect on PHA-induced proliferation.
(16) The mechanism by which gp55 causes increased erythroblastosis and ultimately leukaemia is unknown, but a reasonable suggestion is that gp55 can mimic the action of erythropoietin by binding to its receptor (Epo-R), thereby triggering prolonged proliferation of erythroid cells.
(17) Extensive proliferation has been shown to accompany the de novo generation of LAK cytotoxicity.
(18) Proliferating cells were abundant and scattered throughout the stratified epithelium before the appearance of villi.
(19) Proliferation of quiescent hematopoietic stem cells, purified by cell sorting and evaluated by spleen colony assay (CFU-S), was investigated by measuring the total cell number and CFU-S content and the DNA histogram at 20 and 48 hours of liquid culture.
(20) Whereas the growth and division of normal cells is carefully regulated to meet the needs of the body, tumor cells proliferate autonomously and continually, eventually interfering with and destroying the functions of normal tissue.