(a.) Descending far below the surface; opening or reaching to a great depth; deep.
(a.) Intellectually deep; entering far into subjects; reaching to the bottom of a matter, or of a branch of learning; thorough; as, a profound investigation or treatise; a profound scholar; profound wisdom.
(a.) Characterized by intensity; deeply felt; pervading; overmastering; far-reaching; strongly impressed; as, a profound sleep.
(a.) Bending low, exhibiting or expressing deep humility; lowly; submissive; as, a profound bow.
(n.) The deep; the sea; the ocean.
(n.) An abyss.
(v. t.) To cause to sink deeply; to cause to dive or penetrate far down.
(v. i.) To dive deeply; to penetrate.
Example Sentences:
(1) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(2) Cadavers have a multitude of possible uses--from the harvesting of organs, to medical education, to automotive safety testing--and yet their actual utilization arouses profound aversion no matter how altruistic and beneficial the motivation.
(3) Our positive experiences with IMACS discussed above should be even more profound and profitable for the larger medical institutions.
(4) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(5) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(6) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(7) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(8) After a 2-day incubation with IL-4, expression of IL-2R p55 was markedly induced, but expression of IL2-R p70-75 was profoundly suppressed in a dose-dependent manner.
(9) "For those people who are able to use the laws, the change is profound."
(10) Most striking finding was his difficulty in identifying common objects and colours along with a profound alexia.
(11) This BOA technique was used to test the hearing of 82 profoundly involved handicapped children.
(12) These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
(13) Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia.
(14) Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth.
(15) The reduction in level of activity and adverse changes in body composition caused by SCI have profound metabolic consequences that may influence the progression and severity of coronary artery disease.
(16) The case of a 32-year-old man who suffered a blow to his left supraorbital region and eyebrow in an automatic closing door is reported to draw attention to the uncommon but trivial nature of this injury which may result in profound visual loss.
(17) In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view.
(18) However pneumonia to PC points to a poor prognosis because they are always associated with a profound deficit or cellular immunity.
(19) Thus, it is possible that the loss of these dendritic cells may contribute to the profound immunological abnormalities seen in AIDS.
(20) They produce a more profound effect on clinical and biochemical aspects of rheumatoid arthritis than do the aspirin-like non steroidals.
Sagacious
Definition:
(a.) Of quick sense perceptions; keen-scented; skilled in following a trail.
(a.) Hence, of quick intellectual perceptions; of keen penetration and judgment; discerning and judicious; knowing; far-sighted; shrewd; sage; wise; as, a sagacious man; a sagacious remark.
Example Sentences:
(1) This led directly to Briers working with Branagh on many subsequent projects: as a perhaps too likeable Malvolio ("My best part, and I know it," he said) in an otherwise wintry Twelfth Night at the Riverside Studios, Hammersmith, in 1987, and on a world tour with the Renaissance company as a ropey King Lear (the set really was a mass of ropes, the production dubbed "String Lear") and a sagacious, though not riotously funny, Bottom in A Midsummer Night's Dream.
(2) Election officials have also disqualified Raja Pervaiz Ashraf, the man who until just a few weeks ago was the country's prime minister, under articles ensuring candidates are, among many other things, "sagacious, righteous and non-profligate".
(3) He is a kindly and sagacious presence on our television screens and, in this febrile pre-referendum climate, has attained mystical powers for Scottish nationalists.
(4) As the more sagacious judges tell us, managers are rarely as good as they are cracked up to be when they are winning, and not as bad in adversity.
(5) The nurse's sagacious management of neurologic, hemodynamic and pulmonary status and the ongoing support of the patient and family throughout the angioplasty procedure is crucial to a positive outcome.
(6) The tour was organised by the normally sagacious Dr Ali Bacher, who had been South Africa's last captain before the country was banished from Test cricket at the start of the 1970s.
(7) The captain who guided it through the rapids was the sagacious Lord Bragg, who would rather be remembered as the novelist Melvyn Bragg .
(8) And, now, perhaps seeing the peak of the native advertising bubble, and with the help of the ever-clueless New York Times , it is, sagaciously, ready to get out with whatever it can.
(9) Credit must also go to the sagacious Pékerman whose faith in the young star has allowed Rodríguez to truly blossom.
(10) Because he feels at home in the 12th century, an era of sagacious kings and sustainable cabbages.