(a.) Descending far below the surface; opening or reaching to a great depth; deep.
(a.) Intellectually deep; entering far into subjects; reaching to the bottom of a matter, or of a branch of learning; thorough; as, a profound investigation or treatise; a profound scholar; profound wisdom.
(a.) Characterized by intensity; deeply felt; pervading; overmastering; far-reaching; strongly impressed; as, a profound sleep.
(a.) Bending low, exhibiting or expressing deep humility; lowly; submissive; as, a profound bow.
(n.) The deep; the sea; the ocean.
(n.) An abyss.
(v. t.) To cause to sink deeply; to cause to dive or penetrate far down.
(v. i.) To dive deeply; to penetrate.
Example Sentences:
(1) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(2) Cadavers have a multitude of possible uses--from the harvesting of organs, to medical education, to automotive safety testing--and yet their actual utilization arouses profound aversion no matter how altruistic and beneficial the motivation.
(3) Our positive experiences with IMACS discussed above should be even more profound and profitable for the larger medical institutions.
(4) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(5) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(6) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(7) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(8) After a 2-day incubation with IL-4, expression of IL-2R p55 was markedly induced, but expression of IL2-R p70-75 was profoundly suppressed in a dose-dependent manner.
(9) "For those people who are able to use the laws, the change is profound."
(10) Most striking finding was his difficulty in identifying common objects and colours along with a profound alexia.
(11) This BOA technique was used to test the hearing of 82 profoundly involved handicapped children.
(12) These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
(13) Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia.
(14) Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth.
(15) The reduction in level of activity and adverse changes in body composition caused by SCI have profound metabolic consequences that may influence the progression and severity of coronary artery disease.
(16) The case of a 32-year-old man who suffered a blow to his left supraorbital region and eyebrow in an automatic closing door is reported to draw attention to the uncommon but trivial nature of this injury which may result in profound visual loss.
(17) In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view.
(18) However pneumonia to PC points to a poor prognosis because they are always associated with a profound deficit or cellular immunity.
(19) Thus, it is possible that the loss of these dendritic cells may contribute to the profound immunological abnormalities seen in AIDS.
(20) They produce a more profound effect on clinical and biochemical aspects of rheumatoid arthritis than do the aspirin-like non steroidals.
Sink
Definition:
(v. i.) To fall by, or as by, the force of gravity; to descend lower and lower; to decline gradually; to subside; as, a stone sinks in water; waves rise and sink; the sun sinks in the west.
(v. i.) To enter deeply; to fall or retire beneath or below the surface; to penetrate.
(v. i.) Hence, to enter so as to make an abiding impression; to enter completely.
(v. i.) To be overwhelmed or depressed; to fall slowly, as so the ground, from weakness or from an overburden; to fail in strength; to decline; to decay; to decrease.
(v. i.) To decrease in volume, as a river; to subside; to become diminished in volume or in apparent height.
(v. t.) To cause to sink; to put under water; to immerse or submerge in a fluid; as, to sink a ship.
(v. t.) Figuratively: To cause to decline; to depress; to degrade; hence, to ruin irretrievably; to destroy, as by drowping; as, to sink one's reputation.
(v. t.) To make (a depression) by digging, delving, or cutting, etc.; as, to sink a pit or a well; to sink a die.
(v. t.) To bring low; to reduce in quantity; to waste.
(v. t.) To conseal and appropriate.
(v. t.) To keep out of sight; to suppress; to ignore.
(v. t.) To reduce or extinguish by payment; as, to sink the national debt.
(n.) A drain to carry off filthy water; a jakes.
(n.) A shallow box or vessel of wood, stone, iron, or other material, connected with a drain, and used for receiving filthy water, etc., as in a kitchen.
(n.) A hole or low place in land or rock, where waters sink and are lost; -- called also sink hole.
Example Sentences:
(1) Arterial-type flows produced a pair of vortex sinks downstream of the branching port.
(2) The compromised ice sheet tilts and he sinks into the Arctic Sea on the back of his faltering white Icelandic pony.
(3) These recent Times scoops about Obama's policies do not sink to the level of the Judy Miller debacle.
(4) Comparatively the virus strength sinks more slowly at 4 degrees C in the more mineralized river water (figure 2).
(5) Milk poured from higher (5-10cm above the cup) will sink beneath the surface.
(6) The chylomicrons in particular, become separated from the VLDL, the sinking pre-beta-lipoprotein or Lp (a) was identifiable and the type III hyperlipemia was easily diagnosed.
(7) It’s another squalid reminder of Conservative priorities, and how low they are prepared to sink in pursuit of them.
(8) Chinese drugs constitute a unique medicinal system that features the following three subsystems: subsystem of medicinal substances consisting of traditional theories such as "four properties and five tastes of drugs" and "the principal, adjuvant, auxiliary and conduct ingredients in a prescription' , etc; subsystem of pharmacological actions comprising the theory of "ascending, descending, floating and sinking", etc; Subsystem of human body's functions incorporating the theory of "drugs to act on the channels".
(9) In women, but not in men, there was a rise in the risk of falling from 45 years, peaking in the 55-59 year age group, and sinking to a nadir at ages 70-74.
(10) 81% of all sinks were contaminated with P. aeruginosa strains.
(11) During the early part of the experiments, when the sink condition was maintained, FAH was the most effective for hairless mouse skin, whereas Azone showed the highest effect in the rat skin.
(12) Opening of water taps generated aerosols containing P. aeruginosa sink organisms which contaminated hands during hand washing.
(13) Rats were classified into sinking and non-sinking groups, according to the appearance of sinking behavior over a 2 hr test.
(14) The laminar pattern of current sources and sinks coincident with this component was more complicated after bicuculline, reflecting the summation of current flows associated with disinhibited lamina 4 activity.
(15) But the reality of it began to sink in, and when I met with Kathy Kennedy [the Lucasfilm president and Star Wars executive producer], my gut said this is not something to reject.
(16) For here we see the depravity to which man can sink, the barbarity that unfolds when we begin to see our fellow human beings as somehow less than us, less worthy of dignity and life; we see how evil can, for a moment in time, triumph when good people do nothing."
(17) Waste eluates are collected and drained to the sink by a Teflon tray positioned between the columns and counting tubes, also held by the turntable.
(18) But it has been overwhelmed by the story of the sinking of the Sewol.
(19) Since biogenic particulate products, especially fecal pellets, are known to sink rapidly and intact to the ocean bottom, the transport of PCB's by such sinking particles could be an important mechanism which contributes to the penetration of PCB's into the deep sea.
(20) The receptor component had a current source in the outer segments (90% depth) and a sink in the ONL (70% depth).