(a.) Descending far below the surface; opening or reaching to a great depth; deep.
(a.) Intellectually deep; entering far into subjects; reaching to the bottom of a matter, or of a branch of learning; thorough; as, a profound investigation or treatise; a profound scholar; profound wisdom.
(a.) Characterized by intensity; deeply felt; pervading; overmastering; far-reaching; strongly impressed; as, a profound sleep.
(a.) Bending low, exhibiting or expressing deep humility; lowly; submissive; as, a profound bow.
(n.) The deep; the sea; the ocean.
(n.) An abyss.
(v. t.) To cause to sink deeply; to cause to dive or penetrate far down.
(v. i.) To dive deeply; to penetrate.
Example Sentences:
(1) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(2) Cadavers have a multitude of possible uses--from the harvesting of organs, to medical education, to automotive safety testing--and yet their actual utilization arouses profound aversion no matter how altruistic and beneficial the motivation.
(3) Our positive experiences with IMACS discussed above should be even more profound and profitable for the larger medical institutions.
(4) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(5) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(6) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(7) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(8) After a 2-day incubation with IL-4, expression of IL-2R p55 was markedly induced, but expression of IL2-R p70-75 was profoundly suppressed in a dose-dependent manner.
(9) "For those people who are able to use the laws, the change is profound."
(10) Most striking finding was his difficulty in identifying common objects and colours along with a profound alexia.
(11) This BOA technique was used to test the hearing of 82 profoundly involved handicapped children.
(12) These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
(13) Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia.
(14) Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth.
(15) The reduction in level of activity and adverse changes in body composition caused by SCI have profound metabolic consequences that may influence the progression and severity of coronary artery disease.
(16) The case of a 32-year-old man who suffered a blow to his left supraorbital region and eyebrow in an automatic closing door is reported to draw attention to the uncommon but trivial nature of this injury which may result in profound visual loss.
(17) In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view.
(18) However pneumonia to PC points to a poor prognosis because they are always associated with a profound deficit or cellular immunity.
(19) Thus, it is possible that the loss of these dendritic cells may contribute to the profound immunological abnormalities seen in AIDS.
(20) They produce a more profound effect on clinical and biochemical aspects of rheumatoid arthritis than do the aspirin-like non steroidals.
Subtle
Definition:
(superl.) Sly in design; artful; cunning; insinuating; subtile; -- applied to persons; as, a subtle foe.
(superl.) Cunningly devised; crafty; treacherous; as, a subtle stratagem.
(superl.) Characterized by refinement and niceness in drawing distinctions; nicely discriminating; -- said of persons; as, a subtle logician; refined; tenuous; sinuous; insinuating; hence, penetrative or pervasive; -- said of the mind; its faculties, or its operations; as, a subtle intellect; a subtle imagination; a subtle process of thought; also, difficult of apprehension; elusive.
(superl.) Smooth and deceptive.
Example Sentences:
(1) As a group, the three mammalian proteins resemble bovine serum conglutinin and behave as lectins with rather broad sugar specificities directed at certain non-reducing terminal N-acetylglucosamine, mannose, glucose and fucose residues, but with subtle differences in fine specificities.
(2) But it will be a subtle difference, because it's already abundantly clear there's no danger of the war being suddenly forgotten, or made to seem irrelevant to our sense of what Europe and the world has to avoid repeating.
(3) Communicating sustainability is a subtle attempt at doing good Read more And yet, in environmental terms it is infinitely preferable to prevent waste altogether, rather than recycle it.
(4) If, indeed, there is an immunologic basis for pre-eclampsia, it is more subtle than the methodology used in this study is capable of detecting.
(5) Subtle differences between Chicago urban and Grand Forks rural climates are reflected in arthritic subjects' degree of pain and their perception of pain-related stress.
(6) Critical in this understanding are the subtle changes that occur in the individual patient, reflecting the natural history of the disease or response to its treatment.
(7) Subtle cognitive deficits in Inferential Reading Comprehension were detected when Reading Vocabulary was at or better than a twelfth grade level.
(8) This histochemical difference corresponded to more subtle differences in Nissl and myelin staining patterns, and suggests further structural subdivisions of potential functional significance.
(9) Thus, luciferase transcriptional fusions can detect subtle variations in initial rates of gene expression in a real-time, nondestructive assay.
(10) The binding of [3H]PAF to washed human platelets indicated subtle changes between Days 2 and 4, which became more noticeable by Day 6.
(11) In this study the temperature dependence of the reactivity of aldolase SH groups is investigated in order to detect subtle changes in the enzyme conformation.
(12) The crucial issue of whether subtle behavioral, intellectual, and developmental impairment occurs in young children, as a result of lead-induced CNS damage is discussed in detail.
(13) Historically, what made SNL’s campaign coverage so necessary was its ability to highlight the subtle absurdities of the election and exaggerate the ridiculous.
(14) It is believed that by looking at such subtle shape differences an understanding of what it means morphologically for a primate to be either more or less arboreal may be achieved.
(15) The current magnetic resonance imaging system with computerized image processing is a sensitive and simple method for evaluation of subtle parenchymal changes of the brain.
(16) Fundus examination disclosed a subtle cherry red spot bilaterally.
(17) Ependymal cells developed luminal fronds that projected into the ventricle and the subpial glia displayed a very subtle gliosis in the form of thin multi-laminated processes.
(18) The rapidity of obtaining the results (within one hour), the complete absence of untoward reactions to the radiopharmaceuticals, the much lower frequency of subtle or indeterminate results, the ability to render useful information in the presence of moderate jaundice and the lack of interference from overlying intestinal contents establishes these radionuclide agents as superior to both radiographic oral and intravenous cholangiography in the investigation of the acute abdomen.
(19) Moreover, subtle improvements observed in earlier investigations were not confirmed.
(20) Various compounds show subtle but significant differences in blood clearance, excretion, and soft-tissue uptake.