(a.) Descending far below the surface; opening or reaching to a great depth; deep.
(a.) Intellectually deep; entering far into subjects; reaching to the bottom of a matter, or of a branch of learning; thorough; as, a profound investigation or treatise; a profound scholar; profound wisdom.
(a.) Characterized by intensity; deeply felt; pervading; overmastering; far-reaching; strongly impressed; as, a profound sleep.
(a.) Bending low, exhibiting or expressing deep humility; lowly; submissive; as, a profound bow.
(n.) The deep; the sea; the ocean.
(n.) An abyss.
(v. t.) To cause to sink deeply; to cause to dive or penetrate far down.
(v. i.) To dive deeply; to penetrate.
Example Sentences:
(1) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(2) Cadavers have a multitude of possible uses--from the harvesting of organs, to medical education, to automotive safety testing--and yet their actual utilization arouses profound aversion no matter how altruistic and beneficial the motivation.
(3) Our positive experiences with IMACS discussed above should be even more profound and profitable for the larger medical institutions.
(4) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(5) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(6) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(7) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(8) After a 2-day incubation with IL-4, expression of IL-2R p55 was markedly induced, but expression of IL2-R p70-75 was profoundly suppressed in a dose-dependent manner.
(9) "For those people who are able to use the laws, the change is profound."
(10) Most striking finding was his difficulty in identifying common objects and colours along with a profound alexia.
(11) This BOA technique was used to test the hearing of 82 profoundly involved handicapped children.
(12) These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
(13) Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia.
(14) Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth.
(15) The reduction in level of activity and adverse changes in body composition caused by SCI have profound metabolic consequences that may influence the progression and severity of coronary artery disease.
(16) The case of a 32-year-old man who suffered a blow to his left supraorbital region and eyebrow in an automatic closing door is reported to draw attention to the uncommon but trivial nature of this injury which may result in profound visual loss.
(17) In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view.
(18) However pneumonia to PC points to a poor prognosis because they are always associated with a profound deficit or cellular immunity.
(19) Thus, it is possible that the loss of these dendritic cells may contribute to the profound immunological abnormalities seen in AIDS.
(20) They produce a more profound effect on clinical and biochemical aspects of rheumatoid arthritis than do the aspirin-like non steroidals.
Tremendous
Definition:
(a.) Fitted to excite fear or terror; such as may astonish or terrify by its magnitude, force, or violence; terrible; dreadful; as, a tremendous wind; a tremendous shower; a tremendous shock or fall.
Example Sentences:
(1) John Large, a leading nuclear consultant, said: "The HSE as an independent agency will come under tremendous pressure to push through these designs.
(2) In the last few years, the tremendous growth of clinical transplantations has greatly increased the need for grafts.
(3) Unfortunately, it probably won’t happen with many countries … But if we can have a great relationship with Russia, and China, and all countries, I’m all for that, that would be a tremendous asset.
(4) A decrease in EAA with both the GABA receptor agonist and antagonist and tremendous increase of EAA with the gabamimetic drug, EOS, showed that GABA receptors may not be directly involved in EAA.
(5) As Cavani was shunted of the ball, it broke to Suarez, who aimed a quick-witted toe-poke at the bottom corner from 15 yards, only to be denied by Buffon, who showed tremendous agility to plunge to his right and tip it around the post!
(6) Therefore, reducing the prevalence of smoking in adults from about 40% in 1964 to 29% in 1987 can be considered a tremendous public health achievement.
(7) Ana Nicholls, healthcare analyst at the Economist Intelligence Unit, said: “It is tremendous news that GSK’s long-awaited malaria vaccine has gained approval in Europe.
(8) Specifically, tremendous torques are generated by each of these devices when they are introduced into the coil of a magnetic resonance imager; in addition, the 3M products not only were noted to induce an electrical current, but also were significantly magnetized and rendered afunctional.
(9) During hypoxia of 30 to 90 min duration, induced by nitrogenization of the perfusate, action potential duration (APD) was tremendously decreased in association with decline in the amplitude and rising velocity.
(10) "He had tremendous autonomy which he used to build up his network, and he used the corruption of the state to further his goals."
(11) When Trump described her father as a “tremendous champion of supporting families”, there were boos and hisses.
(12) "These results," said Ban Ki-moon, the UN secretary-general, "represent a tremendous reduction in human suffering and are a clear validation of the approach embodied in the MDGs.
(13) Scott Chambliss (production designer) Since the first film all of us had done different projects, and we all came back with this tremendous appreciation for JJ and collaborating with each other.
(14) In the course of the last two years, a tremendous amount of controversy has been raised over dangers accompanying the use of the antibiotic clindamycin.
(15) Evidence is mounting which indicates substantial conservation of protein structure and function of these receptors and enzymes over these tremendous periods of time.
(16) If their career expectations are to be met the tremendous improvements made in some practices must be extended rapidly to the remainder.
(17) In parts of Northern Ireland, where Irish was effectively banned until the early 1990s, I found a tremendous resurgence taking place.
(18) Assuming it ends without Trump being elected, we have to use this as an opportunity to question a lot of assumptions that vast numbers of people had accepted and he has proved are not true.” If Trump does lose the election, as opinion polls strongly suggest, there will tremendous relief for Schwartz.
(19) 'The real sense of '68 was a tremendous sense of liberation, of freedom,' she says, 'of people talking on the street, in the universities, in theatres.
(20) In case the tidal volume was kept constant, increase of ventilatory rate resulted in a tremendous increase of lung volume, together with considerably higher levels of PEE.