(a.) Descending far below the surface; opening or reaching to a great depth; deep.
(a.) Intellectually deep; entering far into subjects; reaching to the bottom of a matter, or of a branch of learning; thorough; as, a profound investigation or treatise; a profound scholar; profound wisdom.
(a.) Characterized by intensity; deeply felt; pervading; overmastering; far-reaching; strongly impressed; as, a profound sleep.
(a.) Bending low, exhibiting or expressing deep humility; lowly; submissive; as, a profound bow.
(n.) The deep; the sea; the ocean.
(n.) An abyss.
(v. t.) To cause to sink deeply; to cause to dive or penetrate far down.
(v. i.) To dive deeply; to penetrate.
Example Sentences:
(1) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(2) Cadavers have a multitude of possible uses--from the harvesting of organs, to medical education, to automotive safety testing--and yet their actual utilization arouses profound aversion no matter how altruistic and beneficial the motivation.
(3) Our positive experiences with IMACS discussed above should be even more profound and profitable for the larger medical institutions.
(4) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(5) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(6) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(7) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(8) After a 2-day incubation with IL-4, expression of IL-2R p55 was markedly induced, but expression of IL2-R p70-75 was profoundly suppressed in a dose-dependent manner.
(9) "For those people who are able to use the laws, the change is profound."
(10) Most striking finding was his difficulty in identifying common objects and colours along with a profound alexia.
(11) This BOA technique was used to test the hearing of 82 profoundly involved handicapped children.
(12) These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
(13) Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia.
(14) Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth.
(15) The reduction in level of activity and adverse changes in body composition caused by SCI have profound metabolic consequences that may influence the progression and severity of coronary artery disease.
(16) The case of a 32-year-old man who suffered a blow to his left supraorbital region and eyebrow in an automatic closing door is reported to draw attention to the uncommon but trivial nature of this injury which may result in profound visual loss.
(17) In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view.
(18) However pneumonia to PC points to a poor prognosis because they are always associated with a profound deficit or cellular immunity.
(19) Thus, it is possible that the loss of these dendritic cells may contribute to the profound immunological abnormalities seen in AIDS.
(20) They produce a more profound effect on clinical and biochemical aspects of rheumatoid arthritis than do the aspirin-like non steroidals.
Wise
Definition:
(v.) Having knowledge; knowing; enlightened; of extensive information; erudite; learned.
(v.) Hence, especially, making due use of knowledge; discerning and judging soundly concerning what is true or false, proper or improper; choosing the best ends and the best means for accomplishing them; sagacious.
(v.) Versed in art or science; skillful; dexterous; specifically, skilled in divination.
(v.) Dictated or guided by wisdom; containing or exhibiting wisdom; well adapted to produce good effects; judicious; discreet; as, a wise saying; a wise scheme or plan; wise conduct or management; a wise determination.
(v.) Way of being or acting; manner; mode; fashion.
Example Sentences:
(1) A more current view of science, the Probabilistic paradigm, encourages more complex models, which can be articulated as the more flexible maxims used with insight by the wise clinician.
(2) I liked watching Morecambe & Wise, I liked the Queen's speech because it was on and everyone listened to it.
(3) Based on these data, we propose that 19-oxygenated androgen intermediates are biosynthesized sequentially in a step-wise fashion as the cytochrome P450 and NADPH-cytochrome P450 reductase form transient complexes, and that the amount of isolatable 19-oxygenated androgen is proportional to the amount of excess cytochrome P450 component.
(4) But Zambelis added: "Whatever rebel government emerges, China already has a place in the country business-wise.
(5) First, I recapped Die Hard 2 – the insane cross-eyed Gizmo of the Die Hard world – a few months ago, and now I'm secretly determined to do the whole series before the Guardian film editors wise up and yank this feature from my warm, live hands.
(6) At the hearing, committee chairman Senator Patrick Leahy, praised the secret service as "wise, very professional men and women", and called it shocking that so many of the agency's employees were involved in the scandal.
(7) The acid-mediated Z form binds ethidium more weakly than its B counterpart, and the ethidium induced Z to B conversion occurs in a step-wise (non-allosteric) fashion without the requirement of a threshold concentration.
(8) But some wise old heads sniff into their handkerchiefs because they have sat through too many costly "happy ever after" ceremonies that ended in acrimony.
(9) He has to grow up and wise up to the fact that people at West Brom have supported him right from the beginning of his career.
(10) In an attempt to show the public and cabinet colleagues that money being ring-fenced from Treasury cuts will be spent wisely, Mitchell said he wanted to know whether money spent at agencies such as the World Bank and the UN matched up to the government's anti-poverty objectives and delivered real benefits.
(11) The rate constants involved in the step-wise dissociation, process were obtained.
(12) The Republican presidential candidate then told Fox News that Amazon is “getting away with murder tax-wise” and has a “huge antitrust problem because he’s [Bezos] controlling so much”.
(13) Two new bifunctional reagents suited for the step-wise cross-linking of cysteine and lysine residues in proteins are described.
(14) The correction of hallux varus must be performed in a well planned, step-wise method.
(15) It's wise, however, not to concentrate on the exact path of Sandy.
(16) Concentrations of ceftriaxone and cefotaxime were measured by Andrews and Wise in blister fluids, in ascites and pleural fluid by us.
(17) Given a choice between placating the Freedom Caucus and placating Donald Trump, Ryan is wisely choosing self-preservation with the former.
(18) San Antonio wisely takes a timeout hoping to cool him down.
(19) Crozier has had time to play with since he arrived, but the question is whether he has used his first year wisely to build for the future.
(20) After different time intervals following a single or course-wise administration of the compound the level of total lipids was determined in the muscles and liver of the mice, and of the total lipids, beta-lipoproteins, phospholipids, cholesterol, fatty acids and 11-oxycorticosteroids levels in the blood serum of rabbits and of the bile acids content in the vesical bile of these animals.