(a.) In general, a declaration, written or verbal, made by one person to another, which binds the person who makes it to do, or to forbear to do, a specified act; a declaration which gives to the person to whom it is made a right to expect or to claim the performance or forbearance of a specified act.
(a.) An engagement by one person to another, either in words or in writing, but properly not under seal, for the performance or nonperformance of some particular thing. The word promise is used to denote the mere engagement of a person, without regard to the consideration for it, or the corresponding duty of the party to whom it is made.
(a.) That which causes hope, expectation, or assurance; especially, that which affords expectation of future distinction; as, a youth of great promise.
(a.) Bestowal, fulfillment, or grant of what is promised.
(v. t.) To engage to do, give, make, or to refrain from doing, giving, or making, or the like; to covenant; to engage; as, to promise a visit; to promise a cessation of hostilities; to promise the payment of money.
(v. t.) To afford reason to expect; to cause hope or assurance of; as, the clouds promise rain.
(v. t.) To make declaration of or give assurance of, as some benefit to be conferred; to pledge or engage to bestow; as, the proprietors promised large tracts of land; the city promised a reward.
(v. i.) To give assurance by a promise, or binding declaration.
(v. i.) To afford hopes or expectation; to give ground to expect good; rarely, to give reason to expect evil.
Example Sentences:
(1) Yet the Tory promise of fiscal rectitude prevailed in England Alexander had been in charge of Labour’s election strategy, but he could not strategise a victory over a 20-year-old Scottish nationalist who has not yet taken her finals.
(2) The HTCA is promising as a potential tool for studying the biology of tumors.
(3) David Cameron last night hit out at his fellow world leaders after the G8 dropped the promise to meet the historic aid commitments made at Gleneagles in 2005 from this year's summit communique.
(4) The success in these two infertile patients who had already undergone lengthy psychotherapy is promising.
(5) Measuring this value therefore is a very promising procedure.
(6) The Coalition promises to add more misery to their lives.
(7) Meanwhile Ed Miliband, the Labour leader, waiting anxiously for news of the scale of the Labour advance in his first nationwide electoral test, will urge the electorate not to be duped by the promise of a coalition mark 2, predicting sham concessions by the Conservatives .
(8) John Lewis’s marketing, advertising and reputation are all built on their promises of good customer services, and it is a large part of what still drives people to their stores despite cheaper online outlets.
(9) On the basis of reports in the literature and of our own clinical experience it appears that melanocyte inhibiting factor (MIF) is a very promising therapeutic agent in the management of Parkinson's disease.
(10) Since the employment of microwave energy for defrosting biological tissues and for microwave-aided diagnosis in cryosurgery is very promising, the problem of ensuring the match between the contact antennas (applicators) and the frozen biological object has become a pressing one.
(11) The 20-25 year-old cohort was found to yield the most promising results; however, a statistical difference was not found to exist using the volume or area.
(12) The arrest of the Washington Post’s Tehran correspondent Jason Rezaian and his journalist wife, Yeganeh Salehi, as well as a photographer and her partner, is a brutal reminder of the distance between President Hassan Rouhani’s reforming promises and his willingness to act.
(13) The use of a new ultraviolet laser combined with a holographic grating spectrograph promises to increase the number of fluorescing species that can be detected simultaneously.
(14) So is the mock courtroom promising “justice and fairness”.
(15) But that promise was beginning to startle the markets, which admire Monti’s appetite for austerity and fear the free spending and anti-European views of some Italian politicians.
(16) Healthbars such as Nakd fit this category and promise to deliver one of your five a day, based on the quantity of freeze-dried date paste used.
(17) The most promising method was chemoradiotherapy using multifractionation of a daily dose of irradiation, the 4-year survival rate of 20% being achieved.
(18) Trials of these therapeutic schemes promise a higher efficacy of the therapeutic measures for gastroesophageal reflux.
(19) The glory lay in the defiance, although the outcome of the tie scarcely looks promising for Arsenal when the return at Camp Nou next Tuesday is borne in mind.
(20) One of the big sticking points is cash – with rich countries so far failing to live up to promise to mobilise $100bn a year by 2020 for climate finance .
Unbind
Definition:
(v. t.) To remove a band from; to set free from shackles or fastenings; to unite; to unfasten; to loose; as, unbind your fillets; to unbind a prisoner's arms; to unbind a load.
Example Sentences:
(1) Thus, although the fast sodium inactivation process is not required for tonic and use-dependent block of INa by disopyramide, it contributes to the fast phase of block development and unbinding from use-dependent block.
(2) Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated.
(3) Physical theories have been developed to describe many aspects of their conformational behaviour, such as the preferred shapes and shape transformations of closed vesicles, and the shape fluctuations, random-surface configurations, and adhesion and unbinding of interacting membranes.
(4) Assuming a reversible one-to-one binding reaction, the time course of DHO binding and unbinding was analysed under a variety of conditions.
(5) Sanguinarine may produce a K+-like effect upon the Na pump with consequent unbinding of ouabain.
(6) The rate constants for binding and unbinding of ATP were estimated from the dependence of the mean open time on [ATP] and from the Ki.
(7) The rate for unbinding during depolarization was independent of pHo.
(8) We suggest that these conformational changes arise from the unbinding to DNA of certain basic tails of histone(s), and that a competition for DNA binding locations exists upon the reassociation.
(9) These findings suggest than AN-132 has use dependent inhibitory action on the fast sodium channel by binding to the channel mainly during its activated state and that the unbinding rate of the drug during diastole is very slow.
(10) Because in most cases these fit a single exponential with a mean open duration like that of modified channels, we conclude that voltage-dependent toxin unbinding produced a mixed population of unmodified and modified openings.
(11) The extent of the contribution of the process of agonist binding and unbinding to adenylate cyclase activation has not been demonstrated or quantified.
(12) It is interesting that encainide and flecainide unbind slowly (15-20 seconds), whereas lidocaine and moricizine unbind rapidly (0.2-1.3 seconds).
(13) Therefore, sodium channel states regulate the binding and unbinding behaviour of antiarrhythmic drugs.
(14) Such [Ca2+]i-transients in muscle are actually subcellular spatio-temporal events that are determined dynamically by i) diffusional fluxes of Ca2+, ii) by the binding or unbinding of Ca2+ to ligands such as troponin c and calmodulin, and iii) by the various cellular processes, such as release of Ca2+ from sarcoplasmic reticulum, that produce fluxes of Ca2+ across the membranes bounding organelles or the cell.
(15) According to the model, RAC109-I and RAC109-II have significantly different unbinding rate constants for channels when they exist predominantly in rested, activated, or inactivated states, as well as significantly different binding rate constants when channels are activated.
(16) We conclude that binding and unbinding of one molecule of ATP determine the gating of ATP-sensitive K+ channel.
(17) The dissociation rate constant of DHO unbinding remained unchanged (approximately 0.06 s-1).
(18) Estimates of binding and unbinding rate constants for the sodium channel during the action potential plateau and after repolarization were of the same order as previous results obtained using microelectrode methods in vitro.
(19) Increasing the concentration of drug increased the rate of binding but had little or no effect on unbinding, as expected for a simple bimolecular reaction.
(20) Binding and unbinding of MK-801 seems to be possible only if the N-Me-D-Asp-operated channel is in the transmitter-activated state: MK-801 was effective only when applied simultaneously with N-Me-D-Asp, and recovery from MK-801 blockade was speeded by continuous exposure to N-Me-D-Asp [time constant (tau) approximately equal to 90 min at -70 to -80 mV].