(1) At ambient temperature the benzylidene hydrazide of 3-(3,4-dimethoxyphenyl)propenic acid (VII) and a small amount of compound VIII were isolated.
(2) The mutagenic activities of mixtures of nitrogen dioxide and 1,3-butadiene or propene were investigated after uv-irradiation in a small, laboratory-bench scale flow-through gas exposure system.
(3) Feeding 1-amino-3-imino N,N' propene diacetate (AIPD) produced 2 metabolic by products with active aldehyde groups 1-amino propenal acetic acid (APA) and malonyldialdehyde (MDA) that transiently block the lysine epsilon-amino groups of all proteins and lipoproteins in vivo.
(4) Acute toxicity is believed to involve metabolism of allylamine to highly reactive acrolein (2-propenal).
(5) Vinylogous hydroxamic acids (3-(N-hydroxy-N-alkylamino)-2-propen-1-ones, VHA) were prepared as antiinflammatory agents.
(6) (E)- and (Z)-1,2,3-triphenyl-2-propen-1-ones and some of their phenolic and alkoxy analogues, substituted at the para position in one or more of the aromatic rings, were synthesized and assigned geometry on the basis of their spectroscopic data.
(7) All the data taken together suggested that the RPS's were the stereoisomer of 3-(2-ethyl-5-hydroxy-3-oxo) cyclopentanyl-2-propenal.
(8) 1-(2,6-Dihydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-o ne, C17H16O5, Mr = 300.31, orthorhombic, Pbca, a = 27.903 (3), b = 13.958 (2), c = 7.662 (1) A, V = 2984 (1) A3, Z = 8, D chi = 1.337 Mg m-3, lambda(Cu K alpha) = 1.5418 A, mu = 0.729 mm-1, F(000) = 1264, T = 295 K, R = 0.040 for 1702 observed reflections.
(9) The 5'-monophosphate oligonucleotide ends produced from thymine propenal formation have been converted to inorganic phosphate by the action of alkaline phosphatase, and the phosphate has been analyzed for 18O content by 31P NMR spectroscopy.
(10) 1-(Fluoren-2-yl)-2-propen-1-one (vinyl fluorenyl ketone, VFK) was shown to be a potent and irreversible inactivator of NAT II activities.
(11) These data suggest a mechanism of inactivation which involves the transamination of the nascent product to the pyruvoyl group, followed by the elimination of methylthioadenosine and the generation of a 2-propenal equivalent which could undergo a Michael addition to the enzyme.
(12) In the reaction of 3-(3,4-dimethoxyphenyl)propenic acid chloride with benzylidene hydrazide (VII) at 70-80 degrees C, compound VIII was obtained (Scheme 1).
(13) Treatment of calf thymus deoxyribonucleic acid (DNA) with bleomycin-Fe(II) at 0 degree C for 5 min resulted in the formation of 8-hydroxyguanine (8-OH-Gua) residues in DNA in a dose dependent manner, in addition to the formation of base propenal, a DNA-degradation product.
(14) It is a useful intermediate in the preparation of a new class of chromophoric spin label substrates for enzyme studies, as shown by the synthesis of O-3-(2,2,5,5-tetramethylpyrroline-1-oxyl)-propen-2-oyl-L-beta-phenyllactic acid, a specific ester substrate of bovine pancreatic carboxypeptidase A (peptidyl-L-amino acid hydrolase; EC 3.4.12.2).
(15) We have identified a new radiation product (thymin-1'-yl)-propenal as the TBA-reactive product of gamma-irradiation of thymidine.
(16) These phosphate-containing compounds increase both the release of free nucleic base and that of base propenals which are DNA cleavage products, probably by enhancing the efficiency with which Fe(II) is recruited into the drug.
(17) From 3-(3,4-dimethoxyphenyl)propenic acid chloride and substituted amines and hydrazides, the appropriate amides and hydrazides (Table 1) were synthesized at 60-80 degrees C in the medium of benzene or toluene.
(18) Approximately 0.25 ppm butadiene, compared to 100 ppm propene, was needed to give a significant mutagenic effect with 0.25 ppm NO2 after 6 hr exposure.
(19) Male CBA mice were exposed to propene, unlabelled or 14C-labelled, by inhalation, or to 14C-labelled propylene oxide by intraperitoneal injection.
(20) An approximate 1:4 ratio was observed between butadiene and propene which both originate predominantly from vehicle exhaust.
Propylene
Definition:
(n.) A colorless gaseous hydrocarbon (C3H6) of the ethylene series, having a garlic odor. It occurs in coal gas, and is produced artificially in various ways. Called also propene.
Example Sentences:
(1) CZP reduced the incidence of convulsions only after the larger dose, but plain solvent (propylene glycol, ethanol, water) was equally effective.
(2) A hemolytic reaction, probably due to the propylene glycol in the solution, was seen in one case.
(3) At initial concentrations of 0.1 and 1.0 M, glycerin and propylene glycol increase significantly the intestinal absorption rate of theophylline from the small intestine of anesthetized rats.
(4) Therapeutic application of drugs containing propylene glycol 1.2 as a solvent may distort the results of forensic chemical detection of ethylene glycol from its oxidation products.
(5) Practical examples illustrate the possibility of ethylene glycol determination by gas chromatography in the presence of propylene glycol.
(6) Experimental data are presented for: (a) the flux of diflorasone diacetate through hairless mouse skin, (b) the percutaneous penetration profile of propylene glycol, (c) the effects of vehicle concentrations of polyoxypropylene 15 stearyl ether and propylene glycol on the percutaneous flux of diflorasone diacetate, (d) skin--vehicle partition coefficients of diflorasone diacetate, (e) the solubility profile of diflorasone diacetate as a function of solvent concentration, and (f) the alteration of the skin's resistance to the penetration of diflorasone diacetate due to propylene glycol.
(7) Dehydration in ethanol and propylene oxide produces a further 10% shrinkage in volume.
(8) Propylene glycol (PG) is widely used as a drug solvent in the pharmaceutical industry.
(9) Propylene glycol was less effective than polyethylene glycol 400.
(10) On the other hand, propylene glycol, an alcohol sulfotransferase inhibitor, had a profound inhibitory effect on DNA methylation induced by NMHEA, very little effect on the formation of N7-(2-hydroxyethyl)guanine, but a very strong effect on the O6-hydroxyethylguanine lesions.
(11) The SCE frequency was more than doubled in the cultures treated with ethylene oxide and propylene oxide; methyl bromide also induced SCEs.
(12) However, propylene glycol was found to depress all the levels of alkylation in the brachymorphic mice, except for N7-(2-hydroxyethyl)guanine, as was observed in rats.
(13) Of these, 11 were positive to propantheline bromide, 3 to trichlorocarbanilide and one to propylene glycol.
(14) A method for monitoring exposure to ethylene oxide (EO) and propylene oxide (PO) and their corresponding alkenes through the analysis of adducts to N-terminal valine in hemoglobin (Hb) using gas chromatography (GC) and electron-capture detection has been developed.
(15) The CK activity was measured in muscle tissue taken from the injected area (dorsal longissimus muscle) and the contralateral side of the injection site 72 hours after intramuscular injection into rabbits of 1 ml of different dilutions of propylene glycol or glycerol formal in distilled water or 0.9% saline.
(16) We found the application of propylene glycol alone to produce no epidermal changes.
(17) After inhalation exposure, 1,2-epoxybutane was carcinogenic in rodents as were other epoxides or related compounds including propylene oxide, 1,3-butadiene, and ethylene oxide.
(18) The rats received propylene glycol alone (control) or with Actinomycin-D (Act-D) at 08.00 h, followed by EB at 12.00 h on day 3.
(19) Israeli Friesian cows in the third or later lactation, were injected intramuscularly with 1 alpha-hydroxyvitamin D3 in propylene glycol.
(20) Addition of protease inhibitors, phenylmethyl sulfonyl fluoride (PMSF) and ethylenediamine tetra-acetic acid (EDTA), to subzero (-10 degrees C) fixation with propylene glycol and formaldehyde provides reproducible preservation of immunoreactive AII.